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Trait

Reduced progressive sperm motility

A reduced proportion of sperm that move in a straight line or large circles; alternatively, an increased proportion of sperm that move in tight circles or in some other non-linear fashion.

HPO HP:0034011

Summary

Also called
Non-progressive sperm motility
Body system
Abnormality of the genitourinary system

27 genes linked to Reduced progressive sperm motility

Changes in these genes cause rare conditions in which Reduced progressive sperm motility is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.

GeneHow often it is seenConditions
AK9adenylate kinase 9AlwaysIn 1 condition
AKAP3A-kinase anchoring protein 3AlwaysIn 1 condition
ARMC12armadillo repeat containing 12AlwaysIn 1 condition
BRWD1bromodomain and WD repeat domain containing 1AlwaysIn 1 condition
CCDC146coiled-coil domain containing 146AlwaysIn 1 condition
CFAP45cilia and flagella associated protein 45AlwaysIn 1 condition
CFAP54cilia and flagella associated protein 54AlwaysIn 1 condition
CFAP57cilia and flagella associated protein 57AlwaysIn 1 condition
CYLC1cylicin 1AlwaysIn 1 condition
DNAH10dynein axonemal heavy chain 10AlwaysIn 1 condition
DNAH12dynein axonemal heavy chain 12AlwaysIn 1 condition
DNAH7dynein axonemal heavy chain 7AlwaysIn 1 condition
DNALI1dynein axonemal light intermediate chain 1AlwaysIn 1 condition
DNHD1dynein heavy chain domain 1AlwaysIn 1 condition
DRC1dynein regulatory complex subunit 1AlwaysIn 1 condition
FBXO43F-box protein 43AlwaysIn 1 condition
LRRC23leucine rich repeat containing 23AlwaysIn 1 condition
RPL10Lribosomal protein L10 likeAlwaysIn 1 condition
SPACA1sperm acrosome associated 1AlwaysIn 1 condition
SSX1SSX family member 1AlwaysIn 1 condition
STK33serine/threonine kinase 33AlwaysIn 1 condition
TEKT3tektin 3AlwaysIn 1 condition
USP26ubiquitin specific peptidase 26AlwaysIn 1 condition
WDR19WD repeat domain 19AlwaysIn 1 condition
CFAP61cilia and flagella associated protein 61Very often (80–99%)In 1 condition
CCINcalicinOften (30–79%)In 1 condition
IFT74intraflagellar transport 74Often (30–79%)In 1 condition

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Broader traits

Abnormal sperm motility

Where this comes from

  • The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

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