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Trait

Irregularly shaped sperm tail

Irregular or changing caliber (diameter) along the tail of the sperm.

HPO HP:0033393

Summary

Also called
Sperm flagella with irregular caliber, Sperm flagella with irregular calibre
Body system
Abnormality of the genitourinary system

21 genes linked to Irregularly shaped sperm tail

Changes in these genes cause rare conditions in which Irregularly shaped sperm tail is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.

GeneHow often it is seenConditions
BRWD1bromodomain and WD repeat domain containing 1AlwaysIn 1 condition
CCINcalicinAlwaysIn 1 condition
CFAP206cilia and flagella associated protein 206AlwaysIn 1 condition
CFAP251cilia and flagella associated protein 251AlwaysIn 1 condition
CFAP47cilia and flagella associated protein 47AlwaysIn 1 condition
CFAP54cilia and flagella associated protein 54AlwaysIn 1 condition
CFAP57cilia and flagella associated protein 57AlwaysIn 1 condition
CFAP61cilia and flagella associated protein 61AlwaysIn 1 condition
CFAP91cilia and flagella associated protein 91AlwaysIn 1 condition
DNAH1dynein axonemal heavy chain 1AlwaysIn 1 condition
DNAH10dynein axonemal heavy chain 10AlwaysIn 1 condition
DNAH12dynein axonemal heavy chain 12AlwaysIn 1 condition
DNAH8dynein axonemal heavy chain 8AlwaysIn 1 condition
DNHD1dynein heavy chain domain 1AlwaysIn 1 condition
FSIP2fibrous sheath interacting protein 2AlwaysIn 1 condition
IFT74intraflagellar transport 74AlwaysIn 1 condition
SSX1SSX family member 1AlwaysIn 1 condition
STK33serine/threonine kinase 33AlwaysIn 1 condition
WDR19WD repeat domain 19AlwaysIn 1 condition
AK9adenylate kinase 9Very often (80–99%)In 1 condition
CCDC34coiled-coil domain containing 34Often (30–79%)In 1 condition

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Broader traits

Abnormal sperm tail morphology

Where this comes from

  • The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

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