Trait
Low blood sodium levels
Clinical name: Hyponatremia
The concentration of sodium in the blood circulation is below the lower limit of normal.
Summary
- Also called
- Decreased sodium(1+) concentration, Decreased sodium(1+) level, Decreased sodium(1+) level in blood, Reduced sodium(1+) concentration, Reduced sodium(1+) level, Reduced sodium(1+) level in blood
- Body system
- Laboratory abnormality
Reference genomeGRCh38hg38
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Read the genes linked to Low blood sodium levels, and the rest of your genome, with one test.
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Get my Genome Test62 genes linked to Low blood sodium levels
Changes in these genes cause rare conditions in which Low blood sodium levels is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.
| Gene | How often it is seen | Conditions |
|---|---|---|
| ATIC5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase | Always | In 1 condition |
| AVPR2arginine vasopressin receptor 2 | Always | In 1 condition |
| CTNScystinosin, lysosomal cystine transporter | Always | In 2 conditions |
| CYP11B2cytochrome P450 family 11 subfamily B member 2 | Always | In 3 conditions |
| NUP214nucleoporin 214 | Always | In 1 condition |
| PLVAPplasmalemma vesicle associated protein | Always | In 1 condition |
| SARS2seryl-tRNA synthetase 2, mitochondrial | Always | In 1 condition |
| SCNN1Asodium channel epithelial 1 subunit alpha | Always | In 2 conditions |
| SCNN1Gsodium channel epithelial 1 subunit gamma | Always | In 2 conditions |
| CYP11A1cytochrome P450 family 11 subfamily A member 1 | Very often (80–99%) | In 2 conditions |
| NFKB2nuclear factor kappa B subunit 2 | Very often (80–99%) | In 1 condition |
| OCRLOCRL inositol polyphosphate-5-phosphatase | Very often (80–99%) | In 1 condition |
| SCNN1Bsodium channel epithelial 1 subunit beta | Very often (80–99%) | In 2 conditions |
| TBX19T-box transcription factor 19 | Very often (80–99%) | In 1 condition |
| ALG8ALG8 alpha-1,3-glucosyltransferase | Often (30–79%) | In 1 condition |
| BSNDbarttin CLCNK type accessory subunit beta | Often (30–79%) | In 2 conditions |
| CLCNKAchloride voltage-gated channel Ka | Often (30–79%) | In 2 conditions |
| CLCNKBchloride voltage-gated channel Kb | Often (30–79%) | In 2 conditions |
| DZIP1LDAZ interacting zinc finger protein 1 like | Often (30–79%) | In 1 condition |
| GEMIN4gem nuclear organelle associated protein 4 | Often (30–79%) | In 1 condition |
| HSD3B2hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2 | Often (30–79%) | In 2 conditions |
| MC2Rmelanocortin 2 receptor | Often (30–79%) | In 1 condition |
| MRAPmelanocortin 2 receptor accessory protein | Often (30–79%) | In 1 condition |
| NDUFB8NADH:ubiquinone oxidoreductase subunit B8 | Often (30–79%) | In 1 condition |
| NNTnicotinamide nucleotide transhydrogenase | Often (30–79%) | In 1 condition |
| NR0B1nuclear receptor subfamily 0 group B member 1 | Often (30–79%) | In 2 conditions |
| NR3C2nuclear receptor subfamily 3 group C member 2 | Often (30–79%) | In 1 condition |
| PKHD1PKHD1 ciliary IPT domain containing fibrocystin/polyductin | Often (30–79%) | In 1 condition |
| PORcytochrome p450 oxidoreductase | Often (30–79%) | In 1 condition |
| RRAGDRas related GTP binding D | Often (30–79%) | In 1 condition |
| SETD2SET domain containing 2, histone lysine methyltransferase | Often (30–79%) | In 1 condition |
| STARsteroidogenic acute regulatory protein | Often (30–79%) | In 1 condition |
| TBK1TANK binding kinase 1 | Often (30–79%) | In 1 condition |
| TICAM1TIR domain containing adaptor molecule 1 | Often (30–79%) | In 1 condition |
| TLR3toll like receptor 3 | Often (30–79%) | In 1 condition |
| TRAF3TNF receptor associated factor 3 | Often (30–79%) | In 1 condition |
| TSFMTs translation elongation factor, mitochondrial | Often (30–79%) | In 1 condition |
| TXNRD2thioredoxin reductase 2 | Often (30–79%) | In 1 condition |
| UNC93B1unc-93B1 regulator of TLR signaling | Often (30–79%) | In 1 condition |
| ALADaminolevulinate dehydratase | Sometimes (5–29%) | In 1 condition |
Show 22 more genes
| Gene | How often it is seen | Conditions |
|---|---|---|
| AP1S3adaptor related protein complex 1 subunit sigma 3 | Sometimes (5–29%) | In 1 condition |
| ATP6V1B1ATPase H+ transporting V1 subunit B1 | Sometimes (5–29%) | In 1 condition |
| CD4CD4 molecule | Sometimes (5–29%) | In 1 condition |
| CPOXcoproporphyrinogen oxidase | Sometimes (5–29%) | In 1 condition |
| ELP1elongator acetyltransferase complex subunit 1 | Sometimes (5–29%) | In 1 condition |
| FOCADfocadhesin | Sometimes (5–29%) | In 1 condition |
| HMBShydroxymethylbilane synthase | Sometimes (5–29%) | In 1 condition |
| IL36RNinterleukin 36 receptor antagonist | Sometimes (5–29%) | In 1 condition |
| IRF4interferon regulatory factor 4 | Sometimes (5–29%) | In 1 condition |
| LYSTlysosomal trafficking regulator | Sometimes (5–29%) | In 1 condition |
| PAX2paired box 2 | Sometimes (5–29%) | In 1 condition |
| PBX1PBX homeobox 1 | Sometimes (5–29%) | In 1 condition |
| PPOXprotoporphyrinogen oxidase | Sometimes (5–29%) | In 1 condition |
| SCN4Asodium voltage-gated channel alpha subunit 4 | Sometimes (5–29%) | In 1 condition |
| ALG12ALG12 alpha-1,6-mannosyltransferase | Rarely (1–4%) | In 1 condition |
| EIF2AK3eukaryotic translation initiation factor 2 alpha kinase 3 | Rarely (1–4%) | In 1 condition |
| CA12carbonic anhydrase 12 | Not recorded | In 1 condition |
| MAGED2MAGE family member D2 | Not recorded | In 1 condition |
| PRF1perforin 1 | Not recorded | In 1 condition |
| SAMD9sterile alpha motif domain containing 9 | Not recorded | In 1 condition |
| SLC26A3solute carrier family 26 member 3 | Not recorded | In 1 condition |
| TDP2tyrosyl-DNA phosphodiesterase 2 | Not recorded | In 1 condition |
How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.
Broader traits
Where this comes from
- The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
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