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Gene

XK

X-linked Kx blood group antigen, Kell and VPS13A binding protein

Summary

Cytogenetic location
Xp21.1
Coordinates
Chromosome X: 37,685,791–37,732,130 (GRCh38)
Exons
3 exons across 46.3 kb
Protein
444 amino acids
Also known as
XKR1, Kx, X1k
Previous symbols
NA, NAC
MANE Select transcript
ENST00000378616.5NM_021083.4
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated report relevant to this gene

  • Neuroacanthocytosis and Huntington Disease Phenocopies

    • Neuroacanthocytosis

      A group of disorders with abnormally shaped red blood cells and neurodegeneration, including VPS13A-related chorea-acanthocytosis (recessive) and XK-related McLeod syndrome (X-linked).

      • 1 GenCC submitter rates it definitive or strong
      What knowing changes

      Neurological and psychiatric care; people with McLeod syndrome need Kell-compatible blood if transfused.

How XK is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome X, with a bracket where XK sits. XK and 9 genes near it on chromosome X, from 37,208,961 to 38,208,960.Chromosome XXp21.1p22.33p22.32p22.31p22.2p22.13p22.12p22.11p21.3p21.2p21.1p11.4p11.3p11.23p11.22p11.21p11.1q11.1q11.2q12q13.1q13.2q13.3q21.1q21.2q21.31q21.32q21.33q22.1q22.2q22.3q23q24q25q26.1q26.2q26.3q27.1q27.2q27.3q2837.4 Mb37.6 Mb37.8 Mb38 Mb38.2 MbPRRG1: 37,349,269–37,492,702, forward strandPRRG1: 37,349,330–38,687,674, forward strandLANCL3: 37,571,565–37,684,463, forward strandLANCL3XK: 37,685,791–37,732,130, forward strandXKCYBB: 37,780,018–37,816,994, forward strandCYBBDYNLT3: 37,836,611–37,847,593, reverse strandDYNLT3H2AP: 37,990,779–37,991,314, forward strandH2APH2AL3: 37,994,272–37,994,904, forward strandH2AL3SYTL5: 38,006,515–38,128,964, forward strandSYTL5SRPX: 38,149,336–38,220,941, reverse strandSRPXDiagram of XK: 3 exons on the forward strand of chromosome XExon 3: 2 known disease-causing sitesExon 1: 37,685,791–37,686,206, 416 basesExon 2: 37,694,286–37,694,548, 263 basesExon 3: 37,727,636–37,732,130, 4,495 bases1235′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 5.2 kb of the gene's 46.3 kb; 1,335 of those bases code for the protein.

How a genome test reads XK

3

positions in XK where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 46.3 kb of XK, introns included, not only the 5.2 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). XK gene: X-linked Kx blood group antigen, Kell and VPS13A binding protein. Retrieved 17 October 2026, from https://dantelabs.com/genes/xk

Vancouver

Dante Labs. XK gene: X-linked Kx blood group antigen, Kell and VPS13A binding protein [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/xk

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