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Gene

KCNQ3

potassium voltage-gated channel subfamily Q member 3

Summary

Cytogenetic location
8q24.22
Coordinates
Chromosome 8: 132,120,861–132,481,095 (GRCh38)
Exons
15 exons across 360.2 kb
Protein
872 amino acids
Also known as
Kv7.3
Previous symbols
EBN2
MANE Select transcript
ENST00000388996.10NM_004519.4
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated report relevant to this gene

    • Epilepsy (Full Panel)

      • Epilepsy

        One of 171 genes linked to it

        A brain disorder characterized by episodes of abnormally increased neuronal discharge resulting in transient episodes of sensory or motor neurological dysfunction, or psychic dysfunction. These episodes may or may not be associated with loss of consciousness or convulsions.

        • 2 GenCC submitters rate it definitive or strong

    How KCNQ3 is laid out

    • Coding sequence
    • Untranslated region
    • Intron
    • Direction of transcription
    • Known disease-causing sites
    • Stretches short reads find hard
    Chromosome 8, with a bracket where KCNQ3 sits. KCNQ3 and 7 genes near it on chromosome 8, from 131,760,626 to 132,841,330.Chromosome 88q24.22p23.3p23.2p23.1p22p21.3p21.2p21.1p12p11.23p11.22p11.21p11.1q11.1q11.21q11.22q11.23q12.1q12.2q12.3q13.1q13.2q13.3q21.11q21.12q21.13q21.2q21.3q22.1q22.2q22.3q23.1q23.2q23.3q24.11q24.12q24.13q24.21q24.22q24.23q24.3131.8 Mb132 Mb132.2 Mb132.4 Mb132.6 Mb132.8 MbEFR3A: 131,904,072–132,013,642, forward strandEFR3AOC90: 132,024,216–132,059,385, reverse strandOC90: 132,024,238–132,085,655, reverse strandHHLA1: 132,061,141–132,111,159, reverse strandHHLA1KCNQ3: 132,120,861–132,481,095, reverse strandKCNQ3DNAAF11: 132,570,133–132,675,622, reverse strandDNAAF11TMEM71: 132,685,007–132,760,712, reverse strandTMEM71PHF20L1: 132,775,311–132,850,003, forward strandPHF20L1Diagram of KCNQ3: 15 exons on the reverse strand of chromosome 8Exon 13: 1 known disease-causing siteExon 12: 4 known disease-causing sitesExon 11: 2 known disease-causing sitesExon 10: 2 known disease-causing sitesExon 8: 2 known disease-causing sitesExon 7: 6 known disease-causing sitesExon 6: 7 known disease-causing sitesExon 5: 6 known disease-causing sitesExon 4: 5 known disease-causing sitesExon 3: 1 known disease-causing siteExon 1: 4 known disease-causing sitesExon 15: 132,120,861–132,129,996, 9,136 basesExon 14: 132,132,180–132,132,264, 85 basesExon 13: 132,134,290–132,134,388, 99 basesExon 12: 132,137,885–132,138,016, 132 basesExon 11: 132,140,076–132,140,178, 103 basesExon 10: 132,141,129–132,141,331, 203 basesExon 9: 132,163,468–132,163,494, 27 basesExon 8: 132,170,334–132,170,428, 95 basesExon 7: 132,172,598–132,172,693, 96 basesExon 6: 132,174,239–132,174,349, 111 basesExon 5: 132,175,453–132,175,608, 156 basesExon 4: 132,180,157–132,180,329, 173 basesExon 3: 132,184,241–132,184,367, 127 basesExon 2: 132,186,091–132,186,181, 91 basesExon 1: 132,480,147–132,481,095, 949 bases1510515′3′

    Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

    Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

    Nearby genes from Ensembl release 116, on GRCh38.

    Exons make up 11.6 kb of the gene's 360.2 kb; 2,619 of those bases code for the protein.

    How a genome test reads KCNQ3

    45

    positions in KCNQ3 where ClinVar classes a change as pathogenic or likely pathogenic

    None of them falls in a region short reads find hard.

    A whole genome covers all 360.2 kb of KCNQ3, introns included, not only the 11.6 kb of exons.

    Where this comes from

    • HGNC: the gene's symbol, name, other symbols and location.
    • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
    • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
    • The ACMG secondary findings list, SF v3.2.
    • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
    • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
    • Data release 2026.10.16-c6eea6bf.

    Cite this page

    APA

    Dante Labs. (n.d.). KCNQ3 gene: potassium voltage-gated channel subfamily Q member 3. Retrieved 17 October 2026, from https://dantelabs.com/genes/kcnq3

    Vancouver

    Dante Labs. KCNQ3 gene: potassium voltage-gated channel subfamily Q member 3 [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/kcnq3

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