Trait
Abnormal feet structure
Clinical name: Abnormal foot morphology
An abnormality of the skeleton of foot.
Summary
- Also called
- Abnormality of the feet, Abnormality of the foot, Foot deformities, Foot deformity
- Body system
- Abnormality of limbs
Reference genomeGRCh38hg38
Positions on gene and variant pages follow this choice, in this browser.
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Get my Genome Test102 genes linked to Abnormal feet structure
Changes in these genes cause rare conditions in which Abnormal feet structure is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.
| Gene | How often it is seen | Conditions |
|---|---|---|
| PIGAphosphatidylinositol glycan anchor biosynthesis class A | Always | In 1 condition |
| TAF2TATA-box binding protein associated factor 2 | Always | In 2 conditions |
| AEBP1AE binding protein 1 | Very often (80–99%) | In 1 condition |
| GDAP1ganglioside induced differentiation associated protein 1 | Very often (80–99%) | In 1 condition |
| HK1hexokinase 1 | Very often (80–99%) | In 1 condition |
| LMNAlamin A/C | Very often (80–99%) | In 2 conditions |
| MFN2mitofusin 2 | Very often (80–99%) | In 1 condition |
| NEFLneurofilament light chain | Very often (80–99%) | In 1 condition |
| PEX7peroxisomal biogenesis factor 7 | Very often (80–99%) | In 1 condition |
| PHYHphytanoyl-CoA 2-hydroxylase | Very often (80–99%) | In 1 condition |
| SBF2SET binding factor 2 | Very often (80–99%) | In 1 condition |
| SH3TC2SH3 domain and tetratricopeptide repeats 2 | Very often (80–99%) | In 1 condition |
| SLC18A2solute carrier family 18 member A2 | Very often (80–99%) | In 1 condition |
| SLC25A24solute carrier family 25 member 24 | Very often (80–99%) | In 1 condition |
| SLURP1secreted LY6/PLAUR domain containing 1 | Very often (80–99%) | In 1 condition |
| TNXBtenascin XB | Very often (80–99%) | In 1 condition |
| CHRNGcholinergic receptor nicotinic gamma subunit | Often (30–79%) | In 1 condition |
| CHST14carbohydrate sulfotransferase 14 | Often (30–79%) | In 1 condition |
| COL1A1collagen type I alpha 1 chain | Often (30–79%) | In 2 conditions |
| COL1A2collagen type I alpha 2 chain | Often (30–79%) | In 1 condition |
| CPLX1complexin 1 | Often (30–79%) | In 1 condition |
| CTBP1C-terminal binding protein 1 | Often (30–79%) | In 1 condition |
| DACT1dishevelled binding antagonist of beta catenin 1 | Often (30–79%) | In 1 condition |
| DSEdermatan sulfate epimerase | Often (30–79%) | In 1 condition |
| DYRK1Adual specificity tyrosine phosphorylation regulated kinase 1A | Often (30–79%) | In 1 condition |
| FXNfrataxin | Often (30–79%) | In 1 condition |
| HARS1histidyl-tRNA synthetase 1 | Often (30–79%) | In 1 condition |
| HINT1histidine triad nucleotide binding protein 1 | Often (30–79%) | In 2 conditions |
| LETM1leucine zipper and EF-hand containing transmembrane protein 1 | Often (30–79%) | In 1 condition |
| MYH14myosin heavy chain 14 | Often (30–79%) | In 1 condition |
| MYH3myosin heavy chain 3 | Often (30–79%) | In 1 condition |
| NDRG1N-myc downstream regulated 1 | Often (30–79%) | In 1 condition |
| NELFAnegative elongation factor complex member A | Often (30–79%) | In 1 condition |
| NSD2nuclear receptor binding SET domain protein 2 | Often (30–79%) | In 1 condition |
| PIGGphosphatidylinositol glycan anchor biosynthesis class G (EMM blood group) | Often (30–79%) | In 1 condition |
| PRDM5PR/SET domain 5 | Often (30–79%) | In 1 condition |
| PTRH2peptidyl-tRNA hydrolase 2 | Often (30–79%) | In 1 condition |
| RAI1retinoic acid induced 1 | Often (30–79%) | In 1 condition |
| SALL1spalt like transcription factor 1 | Often (30–79%) | In 1 condition |
| SPARTspartin | Often (30–79%) | In 1 condition |
Show 62 more genes
| Gene | How often it is seen | Conditions |
|---|---|---|
| ZNF469zinc finger protein 469 | Often (30–79%) | In 1 condition |
| ADAMTS3ADAM metallopeptidase with thrombospondin type 1 motif 3 | Sometimes (5–29%) | In 1 condition |
| ALDH3A2aldehyde dehydrogenase 3 family member A2 | Sometimes (5–29%) | In 1 condition |
| ASAH1N-acylsphingosine amidohydrolase 1 | Sometimes (5–29%) | In 1 condition |
| ATP13A2ATPase cation transporting 13A2 | Sometimes (5–29%) | In 1 condition |
| AUTS2activator of transcription and developmental regulator AUTS2 | Sometimes (5–29%) | In 1 condition |
| BRCA1BRCA1 DNA repair associated | Sometimes (5–29%) | In 1 condition |
| BRCA2BRCA2 DNA repair associated | Sometimes (5–29%) | In 1 condition |
| BRIP1BRCA1 interacting DNA helicase 1 | Sometimes (5–29%) | In 1 condition |
| CCBE1collagen and calcium binding EGF domains 1 | Sometimes (5–29%) | In 1 condition |
| COL2A1collagen type II alpha 1 chain | Sometimes (5–29%) | In 2 conditions |
| COL5A1collagen type V alpha 1 chain | Sometimes (5–29%) | In 1 condition |
| COL5A2collagen type V alpha 2 chain | Sometimes (5–29%) | In 1 condition |
| ERCC4ERCC excision repair 4, endonuclease catalytic subunit | Sometimes (5–29%) | In 1 condition |
| ERLIN2ER lipid raft associated 2 | Sometimes (5–29%) | In 1 condition |
| FAAP100FA core complex associated protein 100 | Sometimes (5–29%) | In 1 condition |
| FANCAFA complementation group A | Sometimes (5–29%) | In 1 condition |
| FANCBFA complementation group B | Sometimes (5–29%) | In 1 condition |
| FANCCFA complementation group C | Sometimes (5–29%) | In 1 condition |
| FANCD2FA complementation group D2 | Sometimes (5–29%) | In 1 condition |
| FANCEFA complementation group E | Sometimes (5–29%) | In 1 condition |
| FANCFFA complementation group F | Sometimes (5–29%) | In 1 condition |
| FANCGFA complementation group G | Sometimes (5–29%) | In 1 condition |
| FANCIFA complementation group I | Sometimes (5–29%) | In 1 condition |
| FANCLFA complementation group L | Sometimes (5–29%) | In 1 condition |
| FANCMFA complementation group M | Sometimes (5–29%) | In 1 condition |
| FAT4FAT atypical cadherin 4 | Sometimes (5–29%) | In 1 condition |
| MAD2L2mitotic arrest deficient 2 like 2 | Sometimes (5–29%) | In 1 condition |
| MED13Lmediator complex subunit 13L | Sometimes (5–29%) | In 1 condition |
| NEK9NIMA related kinase 9 | Sometimes (5–29%) | In 1 condition |
| PALB2partner and localizer of BRCA2 | Sometimes (5–29%) | In 1 condition |
| PORcytochrome p450 oxidoreductase | Sometimes (5–29%) | In 1 condition |
| RAD51RAD51 recombinase | Sometimes (5–29%) | In 1 condition |
| RAD51CRAD51 paralog C | Sometimes (5–29%) | In 1 condition |
| RFWD3ring finger and WD repeat domain 3 | Sometimes (5–29%) | In 1 condition |
| SACSsacsin molecular chaperone | Sometimes (5–29%) | In 1 condition |
| SLX4SLX4 structure-specific endonuclease subunit | Sometimes (5–29%) | In 1 condition |
| UBE2Tubiquitin conjugating enzyme E2 T | Sometimes (5–29%) | In 1 condition |
| XRCC2X-ray repair cross complementing 2 | Sometimes (5–29%) | In 1 condition |
| ALPLalkaline phosphatase, biomineralization associated | Not recorded | In 1 condition |
| BLTP1bridge-like lipid transfer protein family member 1 | Not recorded | In 1 condition |
| CCN6cellular communication network factor 6 | Not recorded | In 1 condition |
| CCT5chaperonin containing TCP1 subunit 5 | Not recorded | In 1 condition |
| CHD3chromodomain helicase DNA binding protein 3 | Not recorded | In 1 condition |
| CNTNAP1contactin associated protein 1 | Not recorded | In 1 condition |
| CPT2carnitine palmitoyltransferase 2 | Not recorded | In 1 condition |
| DCHS1dachsous cadherin-related 1 | Not recorded | In 1 condition |
| DHODHdihydroorotate dehydrogenase (quinone) | Not recorded | In 1 condition |
| DYNC1H1dynein cytoplasmic 1 heavy chain 1 | Not recorded | In 1 condition |
| EXOSC3exosome component 3 | Not recorded | In 1 condition |
| GJB6gap junction protein beta 6 | Not recorded | In 1 condition |
| HNRNPA1heterogeneous nuclear ribonucleoprotein A1 | Not recorded | In 1 condition |
| MYO9Amyosin IXA | Not recorded | In 1 condition |
| SLC17A5solute carrier family 17 member 5 | Not recorded | In 1 condition |
| SLC9A6solute carrier family 9 member A6 | Not recorded | In 1 condition |
| SYT1synaptotagmin 1 | Not recorded | In 1 condition |
| TMEM216transmembrane protein 216 | Not recorded | In 1 condition |
| TREM2triggering receptor expressed on myeloid cells 2 | Not recorded | In 1 condition |
| TRPV4transient receptor potential cation channel subfamily V member 4 | Not recorded | In 1 condition |
| TYROBPtransmembrane immune signaling adaptor TYROBP | Not recorded | In 1 condition |
| VRK1VRK serine/threonine kinase 1 | Not recorded | In 1 condition |
| YARS1tyrosyl-tRNA synthetase 1 | Not recorded | In 1 condition |
How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.
Narrower traits
- Dropped arches397 genes
- High-arched foot315 genes
- Broad foot40 genes
- Long foot27 genes
- Contractures of the foot joints18 genes
- Split foot14 genes
- Abnormalities of the toes11 genes
- Abnormality of the Achilles tendon9 genes
- Abnormality of the long bone of foot9 genes
- Positional foot deformity7 genes
- Narrow foot6 genes
- Structural foot deformity4 genes
- Abnormal ankle bones3 genes
- Foot bone infection3 genes
- Abnormal foot bone ossification2 genes
- Abnormality of the plantar skin of foot2 genes
- Autoamputation of foot2 genes
- Ankylosis of feet small joints1 gene
- Medial deviation of the foot1 gene
- Medial rotation of the medial malleolus1 gene
- Osteolysis involving bones of the feet1 gene
- Podagra1 gene
- Prominent subcalcaneal fat pad1 gene
- Absent/small foot bones
- Duplication involving bones of the feet
- Fusion involving the bones of the feet
- Hindfoot deformity
Broader traits
Where this comes from
- The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
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