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Trait

Thick corpus callosum

Increased vertical dimension of the corpus callosum. This feature can be visualized by sagittal sections on magnetic resonance tomography imaging of the brain.

HPO HP:0007074

Summary

Also called
Abnormal size of corpus callosum, Large corpus callosum
Body system
Abnormality of the nervous system

21 genes linked to Thick corpus callosum

Changes in these genes cause rare conditions in which Thick corpus callosum is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.

GeneHow often it is seenConditions
MAST1microtubule associated serine/threonine kinase 1AlwaysIn 1 condition
SKOR2SKI family transcriptional corepressor 2AlwaysIn 1 condition
TBC1D7TBC1 domain family member 7AlwaysIn 1 condition
TM2D3TM2 domain containing 3AlwaysIn 1 condition
VPS13Bvacuolar protein sorting 13 homolog BAlwaysIn 1 condition
NONOnon-POU domain containing octamer bindingOften (30–79%)In 1 condition
SLC4A10solute carrier family 4 member 10Often (30–79%)In 1 condition
TUBG1tubulin gamma 1Often (30–79%)In 1 condition
ATP1A2ATPase Na+/K+ transporting subunit alpha 2Sometimes (5–29%)In 1 condition
ATP1A3ATPase Na+/K+ transporting subunit alpha 3Sometimes (5–29%)In 1 condition
C12orf57chromosome 12 open reading frame 57Sometimes (5–29%)In 1 condition
CAMK2Acalcium/calmodulin dependent protein kinase II alphaSometimes (5–29%)In 1 condition
CCND2cyclin D2Sometimes (5–29%)In 1 condition
CNOT3CCR4-NOT transcription complex subunit 3Sometimes (5–29%)In 1 condition
HERC1HECT and RLD domain containing E3 ubiquitin protein ligase family member 1Sometimes (5–29%)In 2 conditions
KDM3Blysine demethylase 3BSometimes (5–29%)In 1 condition
ODC1ornithine decarboxylase 1Sometimes (5–29%)In 1 condition
PRMT7protein arginine methyltransferase 7Sometimes (5–29%)In 1 condition
CNTNAP2contactin associated protein 2Rarely (1–4%)In 1 condition
PIK3R2phosphoinositide-3-kinase regulatory subunit 2Not recordedIn 1 condition
SZT2SZT2 subunit of KICSTOR complexNot recordedIn 1 condition

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Broader traits

Abnormal corpus callosum morphology

Where this comes from

  • The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

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