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Gene

CIROP

ciliated left-right organizer metallopeptidase

Summary

Cytogenetic location
14q11.2
Coordinates
Chromosome 14: 23,099,062–23,104,989 (GRCh38)
Exons
16 exons across 5.9 kb
Protein
788 amino acids
Previous symbols
LMLN2
MANE Select transcript
ENST00000637218.2NM_001354640.2
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated report relevant to this gene

  • Heterotaxy & Laterality Defects

    • Visceral Heterotaxy

      Abnormal left-right arrangement of the internal organs, caused by changes in genes such as ZIC3 (X-linked), NODAL, CFC1, MMP21 and PKD1L1, often with complex heart defects and spleen abnormalities.

      • 1 GenCC submitter rates it definitive or strong
      What knowing changes

      Knowing about it supports heart and abdominal imaging, infection precautions if the spleen is absent, and reproductive counselling.

How CIROP is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
Chromosome 14, with a bracket where CIROP sits. CIROP and 38 genes near it on chromosome 14, from 22,602,026 to 23,602,025.Chromosome 1414q11.2p13p12p11.2p11.1q11.1q11.2q12q13.1q13.2q13.3q21.1q21.2q21.3q22.1q22.2q22.3q23.1q23.2q23.3q24.1q24.2q24.3q31.1q31.2q31.3q32.11q32.12q32.13q32.2q32.31q32.32q32.3322.8 Mb23 Mb23.2 Mb23.4 Mb23.6 MbABHD4: 22,598,243–22,612,963, forward strandABHD4OR6J1: 22,630,929–22,644,352, reverse strandOR6J1OXA1L: 22,766,522–22,776,355, forward strandOXA1LSLC7A7: 22,773,222–22,829,820, reverse strandSLC7A7MRPL52: 22,829,871–22,836,024, forward strandMRPL52MMP14: 22,836,532–22,849,041, forward strandMMP14LRP10: 22,871,709–22,881,713, forward strandLRP10REM2: 22,883,136–22,887,686, forward strandREM2RBM23: 22,893,204–22,919,182, reverse strandRBM23PRMT5: 22,920,108–22,929,458, reverse strandPRMT5HAUS4: 22,946,228–22,957,161, reverse strandHAUS4: 22,946,270–22,982,258, reverse strandAJUBA: 22,971,177–22,982,647, reverse strandAJUBAC14orf93: 22,985,894–23,010,529, reverse strandC14orf93PSMB5: 23,016,540–23,035,239, reverse strandPSMB5PSMB11: 23,042,212–23,044,060, forward strandPSMB11CDH24: 23,047,062–23,057,668, reverse strandCDH24ACIN1: 23,058,561–23,095,614, reverse strandACIN1C14orf119: 23,094,692–23,100,456, forward strandC14orf119CIROP: 23,099,062–23,104,989, reverse strandCIROPCEBPE: 23,117,036–23,120,256, reverse strandCEBPESLC7A8: 23,125,295–23,183,683, reverse strandSLC7A8RNF212B: 23,185,316–23,273,477, forward strandRNF212BHOMEZ: 23,258,697–23,299,796, reverse strandHOMEZPPP1R3E: 23,295,652–23,302,950, reverse strandPPP1R3EBCL2L2: 23,298,790–23,313,069, forward strandBCL2L2BCL2L2-PABPN1: 23,306,833–23,326,175, forward strandPABPN1: 23,321,447–23,326,176, forward strandSLC22A17: 23,346,314–23,352,912, reverse strandEFS: 23,353,248–23,366,287, reverse strandEFSIL25: 23,372,809–23,376,403, forward strandIL25CMTM5: 23,376,627–23,379,772, forward strandCMTM5MYH6: 23,380,206–23,408,945, reverse strandMYH6MYH7: 23,412,732–23,436,137, reverse strandMYH7NGDN: 23,469,464–23,510,024, forward strandNGDNZFHX2: 23,520,851–23,556,192, reverse strandZFHX2THTPA: 23,555,988–23,560,778, forward strandTHTPAAP1G2: 23,559,555–23,569,507, reverse strandAP1G2JPH4: 23,568,035–23,578,856, reverse strandJPH4Diagram of CIROP: 16 exons on the reverse strand of chromosome 14Exon 13: 1 known disease-causing siteExon 12: 1 known disease-causing siteExon 11: 1 known disease-causing siteExon 1: 2 known disease-causing sitesExon 16: 23,099,062–23,099,489, 428 basesExon 15: 23,100,502–23,100,681, 180 basesExon 14: 23,100,850–23,101,079, 230 basesExon 13: 23,101,292–23,101,564, 273 basesExon 12: 23,101,669–23,101,765, 97 basesExon 11: 23,101,842–23,101,911, 70 basesExon 10: 23,102,092–23,102,266, 175 basesExon 9: 23,102,344–23,102,489, 146 basesExon 8: 23,102,629–23,102,713, 85 basesExon 7: 23,102,926–23,103,051, 126 basesExon 6: 23,103,287–23,103,382, 96 basesExon 5: 23,103,471–23,103,548, 78 basesExon 4: 23,103,675–23,103,818, 144 basesExon 3: 23,104,243–23,104,294, 52 basesExon 2: 23,104,385–23,104,469, 85 basesExon 1: 23,104,599–23,104,989, 391 bases161514131211109876543215′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 2.7 kb of the gene's 5.9 kb; 2,367 of those bases code for the protein.

How a genome test reads CIROP

5

positions in CIROP where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 5.9 kb of CIROP, introns included, not only the 2.7 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). CIROP gene: ciliated left-right organizer metallopeptidase. Retrieved 17 October 2026, from https://dantelabs.com/genes/cirop

Vancouver

Dante Labs. CIROP gene: ciliated left-right organizer metallopeptidase [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/cirop

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