Trait
Single ventricle
The presence of only one working lower chamber in the heart, usually with a virtual absence of the ventricular septum and usually present in conjunction with double inlet left or right ventricle.
Summary
- Also called
- Common ventricle
- Body system
- Abnormality of the cardiovascular system
Reference genomeGRCh38hg38
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Get my Genome Test8 genes linked to Single ventricle
Changes in these genes cause rare conditions in which Single ventricle is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.
| Gene | How often it is seen | Conditions |
|---|---|---|
| TXNDC15thioredoxin domain containing 15 | Always | In 1 condition |
| NODALnodal growth differentiation factor | Often (30–79%) | In 1 condition |
| STRA6signaling receptor and transporter of retinol STRA6 | Often (30–79%) | In 1 condition |
| CIROPciliated left-right organizer metallopeptidase | Sometimes (5–29%) | In 1 condition |
| ZIC3Zic family zinc finger 3 | Sometimes (5–29%) | In 1 condition |
| GDF1growth differentiation factor 1 | Not recorded | In 2 conditions |
| NSDHLNAD(P) dependent 3-beta-hydroxysteroid dehydrogenase NSDHL | Not recorded | In 1 condition |
| SIX3SIX homeobox 3 | Not recorded | In 1 condition |
How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.
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Where this comes from
- The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
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