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Gene

ARHGEF6

Rac/Cdc42 guanine nucleotide exchange factor 6

Summary

Cytogenetic location
Xq26.3
Coordinates
Chromosome X: 136,665,550–136,780,932 (GRCh38)
Exons
22 exons across 115.4 kb
Protein
776 amino acids
Also known as
alphaPIX, Cool-2, KIAA0006, alpha-PIX, Cool2, αPix
Previous symbols
MRX46
MANE Select transcript
ENST00000250617.7NM_004840.3
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated reports relevant to this gene

No Genome Test report reads ARHGEF6 yet. The test sequences your whole genome, so your data includes it all the same.

How ARHGEF6 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Stretches short reads find hard
Chromosome X, with a bracket where ARHGEF6 sits. ARHGEF6 and 8 genes near it on chromosome X, from 136,223,241 to 137,223,240.Chromosome XXq26.3p22.33p22.32p22.31p22.2p22.13p22.12p22.11p21.3p21.2p21.1p11.4p11.3p11.23p11.22p11.21p11.1q11.1q11.2q12q13.1q13.2q13.3q21.1q21.2q21.31q21.32q21.33q22.1q22.2q22.3q23q24q25q26.1q26.2q26.3q27.1q27.2q27.3q28136.4 Mb136.6 Mb136.8 Mb137 Mb137.2 MbMAP7D3: 136,213,220–136,256,482, reverse strandMAP7D3ADGRG4: 136,300,963–136,416,890, forward strandADGRG4BRS3: 136,487,947–136,493,784, forward strandBRS3HTATSF1: 136,496,928–136,513,533, forward strandHTATSF1VGLL1: 136,532,135–136,556,807, forward strandVGLL1CD40LG: 136,648,139–136,660,390, forward strandCD40LGARHGEF6: 136,665,550–136,780,932, reverse strandARHGEF6RBMX: 136,847,801–136,880,784, reverse strandRBMXGPR101: 137,023,929–137,033,995, reverse strandGPR101Diagram of ARHGEF6: 22 exons on the reverse strand of chromosome XExon 22: 136,665,550–136,668,169, 2,620 basesExon 21: 136,669,482–136,669,536, 55 basesExon 20: 136,672,020–136,672,119, 100 basesExon 19: 136,675,007–136,675,096, 90 basesExon 18: 136,676,624–136,676,717, 94 basesExon 17: 136,677,936–136,677,956, 21 basesExon 16: 136,679,535–136,679,660, 126 basesExon 15: 136,680,731–136,680,876, 146 basesExon 14: 136,681,890–136,681,968, 79 basesExon 13: 136,682,758–136,682,844, 87 basesExon 12: 136,685,677–136,685,823, 147 basesExon 11: 136,687,932–136,687,991, 60 basesExon 10: 136,690,610–136,690,748, 139 basesExon 9: 136,706,908–136,707,030, 123 basesExon 8: 136,708,675–136,708,770, 96 basesExon 7: 136,713,276–136,713,370, 95 basesExon 6: 136,732,102–136,732,172, 71 basesExon 5: 136,743,585–136,743,786, 202 basesExon 4: 136,745,223–136,745,347, 125 basesExon 3: 136,747,508–136,747,592, 85 basesExon 2: 136,779,414–136,779,497, 84 basesExon 1: 136,780,718–136,780,932, 215 bases22201510515′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 4.9 kb of the gene's 115.4 kb; 2,331 of those bases code for the protein.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.

Cite this page

APA

Dante Labs. (n.d.). ARHGEF6 gene: Rac/Cdc42 guanine nucleotide exchange factor 6. Retrieved 17 October 2026, from https://dantelabs.com/genes/arhgef6

Vancouver

Dante Labs. ARHGEF6 gene: Rac/Cdc42 guanine nucleotide exchange factor 6 [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/arhgef6

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