Traits

Traits linked to WNT7A

Wnt family member 7A

The Human Phenotype Ontology links 99 traits to WNT7A, by body system: features seen in people with one of the gene's rare conditions.

Abnormality of limbs

Trait	Kui sageli seda täheldatakse
Absent/small extremities	Alati
Abnormality of the shankbone	Väga sageli (80–99%)
Absence/underdevelopment of inner forearm bone	Väga sageli (80–99%)
Absent calf bone	Väga sageli (80–99%)
Absent fingers	Väga sageli (80–99%)
Absent/small calf bone	Väga sageli (80–99%)
Absent/small thighbone	Väga sageli (80–99%)
Aplasia of the ulna	Väga sageli (80–99%)
Bowed thighbone	Väga sageli (80–99%)
Bowing of outer large bone of the forearm	Väga sageli (80–99%)
Bowing of the long bones	Väga sageli (80–99%)
Cleft hand	Väga sageli (80–99%)
Missing toes	Väga sageli (80–99%)
Short foot	Väga sageli (80–99%)
Smaller or shorter than typical limbs	Väga sageli (80–99%)
Underdeveloped outer large forearm bone	Väga sageli (80–99%)
Abnormal finger flexion crease	Sageli (30–79%)
Absent kneecap	Sageli (30–79%)
Absent/small ankle bone	Sageli (30–79%)
Absent/small fingers	Sageli (30–79%)
Absent/small little finger	Sageli (30–79%)
Absent/small long bone of foot	Sageli (30–79%)
Absent/small long bones of hand	Sageli (30–79%)
Absent/small toe bones	Sageli (30–79%)
Absent/small wrist bones	Sageli (30–79%)
Aplasia/Hypoplasia of the phalanges of the hand	Sageli (30–79%)
Club feet	Sageli (30–79%)
Dislocated hip since birth	Sageli (30–79%)
Elbow ankylosis	Sageli (30–79%)
Elbow flexion contracture	Sageli (30–79%)
Extra little finger	Sageli (30–79%)
Finger bends toward pinky	Sageli (30–79%)
Fused toes	Sageli (30–79%)
Fusion of upper and lower arm bones	Sageli (30–79%)
Phocomelia	Sageli (30–79%)
Split hand	Sageli (30–79%)
Finger syndactyly	Mõnikord (5–29%)
Hip dislocation	Mõnikord (5–29%)
Talipes	Mõnikord (5–29%)
Absent wrist bone	Pole registreeritud
Curvature of digit	Pole registreeritud
Front half of foot turns inward	Pole registreeritud
Knock knees	Pole registreeritud
More than five fingers or toes on hands or feet	Pole registreeritud
Oligodactyly	Pole registreeritud
Postaxial polydactyly	Pole registreeritud
Preaxial polydactyly	Pole registreeritud
Short fingers or toes	Pole registreeritud
Webbed fingers or toes	Pole registreeritud

Abnormality of the musculoskeletal system

Trait	Kui sageli seda täheldatakse
Absent/small sacrum	Väga sageli (80–99%)
Aplasia/Hypoplasia involving the pelvis	Väga sageli (80–99%)
Absent/small pubic bones	Sageli (30–79%)
Barrel-shaped chest	Sageli (30–79%)
Broad collarbone	Sageli (30–79%)
Broad ribs	Sageli (30–79%)
Hypoplastic iliac wing	Sageli (30–79%)
Hypoplastic pelvis	Sageli (30–79%)
Prominent sternum	Sageli (30–79%)
Absent pubic bones	Pole registreeritud
Congenital pseudoarthrosis of the clavicle	Pole registreeritud
Missing part of vertebrae	Pole registreeritud
Pigeon chest	Pole registreeritud
Pilonidal sinus	Pole registreeritud

Abnormality of head or neck

Trait	Kui sageli seda täheldatakse
Broad neck	Sageli (30–79%)
Little lower jaw	Sageli (30–79%)
Long face	Sageli (30–79%)
Short neck	Sageli (30–79%)
Cleft palate	Mõnikord (5–29%)
Cranial defect	Mõnikord (5–29%)
High, narrow palate	Mõnikord (5–29%)
Short nose	Mõnikord (5–29%)
Eye folds	Pole registreeritud
High palate	Pole registreeritud
Narrow palate	Pole registreeritud
Soft skullcap	Pole registreeritud
Wide nasal bridge	Pole registreeritud

Abnormality of the genitourinary system

Trait	Kui sageli seda täheldatakse
Anteriorly displaced genitalia	Väga sageli (80–99%)
Absent uterus	Sageli (30–79%)
Smaller than typical growth of scrotum	Sageli (30–79%)
Undescended testes	Sageli (30–79%)
Underdeveloped penis	Mõnikord (5–29%)
Abnormal absence of menstruation	Pole registreeritud
Hypospadias	Pole registreeritud

Abnormality of the ear

Trait	Kui sageli seda täheldatakse
Prominent ear	Mõnikord (5–29%)
Abnormally shaped ears	Pole registreeritud
Long ear	Pole registreeritud
Low-set ears	Pole registreeritud

Abnormality of the integument

Trait	Kui sageli seda täheldatakse
Atypical nail growth	Väga sageli (80–99%)
Absent nails	Pole registreeritud
Absent toenail	Pole registreeritud

Growth abnormality

Trait	Kui sageli seda täheldatakse
Disproportionate short stature	Väga sageli (80–99%)
Prenatal growth deficiency	Sageli (30–79%)
Short stature	Sageli (30–79%)

Abnormality of the digestive system

Trait	Kui sageli seda täheldatakse
Abnormal connection between trachea and esophagus	Mõnikord (5–29%)
Absent anus	Mõnikord (5–29%)

Abnormality of the nervous system

Trait	Kui sageli seda täheldatakse
Meningocele	Mõnikord (5–29%)
Occipital meningocele	Mõnikord (5–29%)

Abnormality of the breast

Trait	Kui sageli seda täheldatakse
Small nipples	Pole registreeritud

Laboratory abnormality

Trait	Kui sageli seda täheldatakse
Hydrops fetalis	Mõnikord (5–29%)

Kui sageli see esineb geenist tulenevate seisunditega inimeste seas, kõige sagedamini nende kõigi seas, nagu on märgitud Inimese fenotüübi ontoloogias. Need lehed kirjeldavad tunnuseid ja nende taga olevaid uuringuid; need ei ole diagnoos ning sümptomite kohta tuleks küsida arstilt või geneetilt nõustajalt.

Allikas

The Human Phenotype Ontology, release 2026-09-01: the traits linked to WNT7A and how often each is seen. Find out more at hpo.jax.org.

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