Traits

Traits linked to WNT7A

Wnt family member 7A

The Human Phenotype Ontology links 99 traits to WNT7A, by body system: features seen in people with one of the gene's rare conditions.

Abnormality of limbs

Trait	How often it is seen
Absent/small extremities	Always
Abnormality of the shankbone	Very often (80–99%)
Absence/underdevelopment of inner forearm bone	Very often (80–99%)
Absent calf bone	Very often (80–99%)
Absent fingers	Very often (80–99%)
Absent/small calf bone	Very often (80–99%)
Absent/small thighbone	Very often (80–99%)
Aplasia of the ulna	Very often (80–99%)
Bowed thighbone	Very often (80–99%)
Bowing of outer large bone of the forearm	Very often (80–99%)
Bowing of the long bones	Very often (80–99%)
Cleft hand	Very often (80–99%)
Missing toes	Very often (80–99%)
Short foot	Very often (80–99%)
Smaller or shorter than typical limbs	Very often (80–99%)
Underdeveloped outer large forearm bone	Very often (80–99%)
Abnormal finger flexion crease	Often (30–79%)
Absent kneecap	Often (30–79%)
Absent/small ankle bone	Often (30–79%)
Absent/small fingers	Often (30–79%)
Absent/small little finger	Often (30–79%)
Absent/small long bone of foot	Often (30–79%)
Absent/small long bones of hand	Often (30–79%)
Absent/small toe bones	Often (30–79%)
Absent/small wrist bones	Often (30–79%)
Aplasia/Hypoplasia of the phalanges of the hand	Often (30–79%)
Club feet	Often (30–79%)
Dislocated hip since birth	Often (30–79%)
Elbow ankylosis	Often (30–79%)
Elbow flexion contracture	Often (30–79%)
Extra little finger	Often (30–79%)
Finger bends toward pinky	Often (30–79%)
Fused toes	Often (30–79%)
Fusion of upper and lower arm bones	Often (30–79%)
Phocomelia	Often (30–79%)
Split hand	Often (30–79%)
Finger syndactyly	Sometimes (5–29%)
Hip dislocation	Sometimes (5–29%)
Talipes	Sometimes (5–29%)
Absent wrist bone	Not recorded
Curvature of digit	Not recorded
Front half of foot turns inward	Not recorded
Knock knees	Not recorded
More than five fingers or toes on hands or feet	Not recorded
Oligodactyly	Not recorded
Postaxial polydactyly	Not recorded
Preaxial polydactyly	Not recorded
Short fingers or toes	Not recorded
Webbed fingers or toes	Not recorded

Abnormality of the musculoskeletal system

Trait	How often it is seen
Absent/small sacrum	Very often (80–99%)
Aplasia/Hypoplasia involving the pelvis	Very often (80–99%)
Absent/small pubic bones	Often (30–79%)
Barrel-shaped chest	Often (30–79%)
Broad collarbone	Often (30–79%)
Broad ribs	Often (30–79%)
Hypoplastic iliac wing	Often (30–79%)
Hypoplastic pelvis	Often (30–79%)
Prominent sternum	Often (30–79%)
Absent pubic bones	Not recorded
Congenital pseudoarthrosis of the clavicle	Not recorded
Missing part of vertebrae	Not recorded
Pigeon chest	Not recorded
Pilonidal sinus	Not recorded

Abnormality of head or neck

Trait	How often it is seen
Broad neck	Often (30–79%)
Little lower jaw	Often (30–79%)
Long face	Often (30–79%)
Short neck	Often (30–79%)
Cleft palate	Sometimes (5–29%)
Cranial defect	Sometimes (5–29%)
High, narrow palate	Sometimes (5–29%)
Short nose	Sometimes (5–29%)
Eye folds	Not recorded
High palate	Not recorded
Narrow palate	Not recorded
Soft skullcap	Not recorded
Wide nasal bridge	Not recorded

Abnormality of the genitourinary system

Trait	How often it is seen
Anteriorly displaced genitalia	Very often (80–99%)
Absent uterus	Often (30–79%)
Smaller than typical growth of scrotum	Often (30–79%)
Undescended testes	Often (30–79%)
Underdeveloped penis	Sometimes (5–29%)
Abnormal absence of menstruation	Not recorded
Hypospadias	Not recorded

Abnormality of the ear

Trait	How often it is seen
Prominent ear	Sometimes (5–29%)
Abnormally shaped ears	Not recorded
Long ear	Not recorded
Low-set ears	Not recorded

Abnormality of the integument

Trait	How often it is seen
Atypical nail growth	Very often (80–99%)
Absent nails	Not recorded
Absent toenail	Not recorded

Growth abnormality

Trait	How often it is seen
Disproportionate short stature	Very often (80–99%)
Prenatal growth deficiency	Often (30–79%)
Short stature	Often (30–79%)

Abnormality of the digestive system

Trait	How often it is seen
Abnormal connection between trachea and esophagus	Sometimes (5–29%)
Absent anus	Sometimes (5–29%)

Abnormality of the nervous system

Trait	How often it is seen
Meningocele	Sometimes (5–29%)
Occipital meningocele	Sometimes (5–29%)

Abnormality of the breast

Trait	How often it is seen
Small nipples	Not recorded

Laboratory abnormality

Trait	How often it is seen
Hydrops fetalis	Sometimes (5–29%)

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Where this comes from

The Human Phenotype Ontology, release 2026-09-01: the traits linked to WNT7A and how often each is seen. Find out more at hpo.jax.org.

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