Trait
Hypopigmented macule
A white or lighter patch of skin that may appear anywhere on the body and are caused by decreased skin pigmentation.
Summary
- Body system
- Abnormality of the integument
Reference genomeGRCh38hg38
Positions on gene and variant pages follow this choice, in this browser.
Read the genes linked to Hypopigmented macule, and the rest of your genome, with one test.
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Get my Genome Test13 genes linked to Hypopigmented macule
Changes in these genes cause rare conditions in which Hypopigmented macule is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.
| Gene | How often it is seen | Conditions |
|---|---|---|
| ANKLE2ankyrin repeat and LEM domain containing 2 | Always | In 1 condition |
| ENPP1ectonucleotide pyrophosphatase/phosphodiesterase 1 | Always | In 1 condition |
| FANCCFA complementation group C | Always | In 1 condition |
| GPNMBglycoprotein nmb | Always | In 1 condition |
| OSBPL2oxysterol binding protein like 2 | Always | In 1 condition |
| PLECplectin | Often (30–79%) | In 1 condition |
| SPECC1Lsperm antigen with calponin homology and coiled-coil domains 1 like | Often (30–79%) | In 1 condition |
| KRT5keratin 5 | Rarely (1–4%) | In 1 condition |
| POFUT1protein O-fucosyltransferase 1 | Rarely (1–4%) | In 1 condition |
| POGLUT1protein O-glucosyltransferase 1 | Rarely (1–4%) | In 1 condition |
| PSENENpresenilin enhancer, gamma-secretase subunit | Rarely (1–4%) | In 1 condition |
| ABCB6ATP binding cassette subfamily B member 6 (LAN blood group) | Not recorded | In 1 condition |
| NF1neurofibromin 1 | Not recorded | In 1 condition |
How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.
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Where this comes from
- The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
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