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Gene

IMPDH2

inosine monophosphate dehydrogenase 2

Summary

Cytogenetic location
3p21.31
Coordinates
Chromosome 3: 49,024,325–49,029,398 (GRCh38)
Exons
14 exons across 5.1 kb
Protein
514 amino acids
MANE Select transcript
ENST00000326739.9NM_000884.3
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated reports relevant to this gene

No Genome Test report reads IMPDH2 yet. The test sequences your whole genome, so your data includes it all the same.

How IMPDH2 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
Chromosome 3, with a bracket where IMPDH2 sits. IMPDH2 and 35 genes near it on chromosome 3, from 48,526,862 to 49,526,861.Chromosome 33p21.31p26.3p26.2p26.1p25.3p25.2p25.1p24.3p24.2p24.1p23p22.3p22.2p22.1p21.33p21.32p21.31p21.2p21.1p14.3p14.2p14.1p13p12.3p12.2p12.1p11.2p11.1q11.1q11.2q12.1q12.2q12.3q13.11q13.12q13.13q13.2q13.31q13.32q13.33q21.1q21.2q21.3q22.1q22.2q22.3q23q24q25.1q25.2q25.31q25.32q25.33q26.1q26.2q26.31q26.32q26.33q27.1q27.2q27.3q28q2948.6 Mb48.8 Mb49 Mb49.2 Mb49.4 MbPFKFB4: 48,517,668–48,562,015, reverse strandPFKFB4UCN2: 48,561,718–48,563,781, reverse strandUCN2COL7A1: 48,564,073–48,595,596, reverse strandCOL7A1UQCRC1: 48,598,990–48,610,976, reverse strandUQCRC1TMEM89: 48,620,759–48,621,769, reverse strandTMEM89SLC26A6: 48,625,718–48,635,510, reverse strandSLC26A6CELSR3: 48,636,463–48,662,886, reverse strandCELSR3NCKIPSD: 48,662,986–48,686,364, reverse strandNCKIPSDIP6K2: 48,688,003–48,740,353, reverse strandIP6K2PRKAR2A: 48,744,591–48,847,894, reverse strandPRKAR2ASLC25A20: 48,856,926–48,898,993, reverse strandSLC25A20ARIH2: 48,918,217–48,986,382, forward strandP4HTM: 48,989,858–49,007,153, forward strandWDR6: 49,007,062–49,015,953, forward strandWDR6DALRD3: 49,015,474–49,022,293, reverse strandDALRD3NDUFAF3: 49,020,459–49,027,593, forward strandNDUFAF3IMPDH2: 49,024,325–49,029,398, reverse strandIMPDH2: 49,024,345–49,094,071, reverse strandQRICH1: 49,029,700–49,094,545, reverse strandQARS1: 49,095,932–49,105,130, reverse strandQARS1USP19: 49,105,758–49,120,940, reverse strandUSP19LAMB2: 49,121,113–49,133,118, reverse strandLAMB2CCDC71: 49,161,063–49,166,357, reverse strandCCDC71KLHDC8B: 49,171,239–49,176,487, forward strandKLHDC8BCIMIP7: 49,177,634–49,191,858, reverse strandCIMIP7IHO1: 49,198,428–49,277,629, forward strandIHO1C3orf62: 49,268,596–49,277,236, reverse strandC3orf62USP4: 49,277,144–49,340,712, reverse strandUSP4GPX1: 49,357,174–49,358,605, reverse strandGPX1: 49,357,176–49,412,051, reverse strandRHOA: 49,359,136–49,412,998, reverse strandRHOATCTA: 49,412,212–49,455,826, forward strandAMT: 49,416,771–49,422,685, reverse strandAMT: 49,416,777–49,429,314, reverse strandNICN1: 49,422,333–49,429,331, reverse strandDAG1: 49,468,649–49,535,624, forward strandDAG1Diagram of IMPDH2: 14 exons on the reverse strand of chromosome 3Exon 14: 49,024,325–49,024,404, 80 basesExon 13: 49,024,495–49,024,578, 84 basesExon 12: 49,024,659–49,024,802, 144 basesExon 11: 49,024,896–49,025,040, 145 basesExon 10: 49,025,126–49,025,269, 144 basesExon 9: 49,026,324–49,026,419, 96 basesExon 8: 49,026,519–49,026,609, 91 basesExon 7: 49,026,687–49,026,886, 200 basesExon 6: 49,026,960–49,027,047, 88 basesExon 5: 49,027,710–49,027,916, 207 basesExon 4: 49,028,248–49,028,322, 75 basesExon 3: 49,028,431–49,028,532, 102 basesExon 2: 49,028,758–49,028,806, 49 basesExon 1: 49,029,253–49,029,398, 146 bases14131211109876543215′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 1.7 kb of the gene's 5.1 kb; 1,545 of those bases code for the protein.

How a genome test reads IMPDH2

1

position in IMPDH2 where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 5.1 kb of IMPDH2, introns included, not only the 1.7 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). IMPDH2 gene: inosine monophosphate dehydrogenase 2. Retrieved 16 October 2026, from https://dantelabs.com/genes/impdh2

Vancouver

Dante Labs. IMPDH2 gene: inosine monophosphate dehydrogenase 2 [Internet]. [cited 16 October 2026]. Available from: https://dantelabs.com/genes/impdh2

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