{
  "url": "https://dantelabs.com/traits/accelerated-skeletal-maturation",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "accelerated-skeletal-maturation",
    "id": "HP:0005616",
    "name": "Advanced bone age",
    "label": "Accelerated skeletal maturation",
    "definition": "An abnormally increased rate of skeletal maturation. Accelerated skeletal maturation can be diagnosed on the basis of an estimation of the bone age from radiographs of specific bones in the human body.",
    "synonyms": [
      "Early bone maturation",
      "Premature epiphyseal closure",
      "Premature epiphyseal ossification",
      "Premature fusion of the epiphyseal growth plate"
    ],
    "systems": [
      {
        "slug": "abnormality-of-the-musculoskeletal-system",
        "name": "Abnormality of the musculoskeletal system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-musculoskeletal-system"
      }
    ],
    "broader": [
      {
        "slug": "abnormality-of-skeletal-maturation",
        "name": "Abnormality of skeletal maturation",
        "url": "https://dantelabs.com/traits/abnormality-of-skeletal-maturation"
      }
    ],
    "narrower": [
      {
        "slug": "accelerated-bone-age-after-puberty",
        "name": "Accelerated bone age after puberty",
        "genes": 1,
        "url": "https://dantelabs.com/traits/accelerated-bone-age-after-puberty"
      }
    ],
    "genes": [
      {
        "slug": "acan",
        "symbol": "ACAN",
        "hgnc": "HGNC:319",
        "name": "aggrecan",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/acan"
      },
      {
        "slug": "amotl1",
        "symbol": "AMOTL1",
        "hgnc": "HGNC:17811",
        "name": "angiomotin like 1",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/amotl1"
      },
      {
        "slug": "csgalnact1",
        "symbol": "CSGALNACT1",
        "hgnc": "HGNC:24290",
        "name": "chondroitin sulfate N-acetylgalactosaminyltransferase 1",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/csgalnact1"
      },
      {
        "slug": "ddost",
        "symbol": "DDOST",
        "hgnc": "HGNC:2728",
        "name": "dolichyl-diphosphooligosaccharide--protein glycosyltransferase non-catalytic subunit",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/ddost"
      },
      {
        "slug": "eed",
        "symbol": "EED",
        "hgnc": "HGNC:3188",
        "name": "embryonic ectoderm development",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/eed"
      },
      {
        "slug": "efemp1",
        "symbol": "EFEMP1",
        "hgnc": "HGNC:3218",
        "name": "EGF-like fibulin extracellular matrix protein 1",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/efemp1"
      },
      {
        "slug": "ezh2",
        "symbol": "EZH2",
        "hgnc": "HGNC:3527",
        "name": "enhancer of zeste 2 polycomb repressive complex 2 subunit",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/ezh2"
      },
      {
        "slug": "gusb",
        "symbol": "GUSB",
        "hgnc": "HGNC:4696",
        "name": "glucuronidase beta",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/gusb"
      },
      {
        "slug": "prkar1a",
        "symbol": "PRKAR1A",
        "hgnc": "HGNC:9388",
        "name": "protein kinase cAMP-dependent type I regulatory subunit alpha",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/prkar1a"
      },
      {
        "slug": "psmd12",
        "symbol": "PSMD12",
        "hgnc": "HGNC:9557",
        "name": "proteasome 26S subunit, non-ATPase 12",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/psmd12"
      },
      {
        "slug": "ptbp1",
        "symbol": "PTBP1",
        "hgnc": "HGNC:9583",
        "name": "polypyrimidine tract binding protein 1",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ptbp1"
      },
      {
        "slug": "tcf20",
        "symbol": "TCF20",
        "hgnc": "HGNC:11631",
        "name": "transcription factor 20",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tcf20"
      },
      {
        "slug": "tshr",
        "symbol": "TSHR",
        "hgnc": "HGNC:12373",
        "name": "thyroid stimulating hormone receptor",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/tshr"
      },
      {
        "slug": "aip",
        "symbol": "AIP",
        "hgnc": "HGNC:358",
        "name": "AHR interacting HSP90 co-chaperone",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/aip"
      },
      {
        "slug": "cant1",
        "symbol": "CANT1",
        "hgnc": "HGNC:19721",
        "name": "calcium activated nucleotidase 1",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cant1"
      },
      {
        "slug": "cyp11b1",
        "symbol": "CYP11B1",
        "hgnc": "HGNC:2591",
        "name": "cytochrome P450 family 11 subfamily B member 1",
        "frequency": "very-frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/cyp11b1"
      },
      {
        "slug": "insr",
        "symbol": "INSR",
        "hgnc": "HGNC:6091",
        "name": "insulin receptor",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/insr"
      },
      {
        "slug": "lhcgr",
        "symbol": "LHCGR",
        "hgnc": "HGNC:6585",
        "name": "luteinizing hormone/choriogonadotropin receptor",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/lhcgr"
      },
      {
        "slug": "men1",
        "symbol": "MEN1",
        "hgnc": "HGNC:7010",
        "name": "menin 1",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/men1"
      },
      {
        "slug": "nfix",
        "symbol": "NFIX",
        "hgnc": "HGNC:7788",
        "name": "nuclear factor I X",
        "frequency": "very-frequent",
        "diseases": 4,
        "url": "https://dantelabs.com/genes/nfix"
      },
      {
        "slug": "nsd1",
        "symbol": "NSD1",
        "hgnc": "HGNC:14234",
        "name": "nuclear receptor binding SET domain protein 1",
        "frequency": "very-frequent",
        "diseases": 3,
        "url": "https://dantelabs.com/genes/nsd1"
      },
      {
        "slug": "pde4d",
        "symbol": "PDE4D",
        "hgnc": "HGNC:8783",
        "name": "phosphodiesterase 4D",
        "frequency": "very-frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/pde4d"
      },
      {
        "slug": "pth1r",
        "symbol": "PTH1R",
        "hgnc": "HGNC:9608",
        "name": "parathyroid hormone 1 receptor",
        "frequency": "very-frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/pth1r"
      },
      {
        "slug": "suz12",
        "symbol": "SUZ12",
        "hgnc": "HGNC:17101",
        "name": "SUZ12 polycomb repressive complex 2 subunit",
        "frequency": "very-frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/suz12"
      },
      {
        "slug": "xylt1",
        "symbol": "XYLT1",
        "hgnc": "HGNC:15516",
        "name": "xylosyltransferase 1",
        "frequency": "very-frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/xylt1"
      },
      {
        "slug": "apc2",
        "symbol": "APC2",
        "hgnc": "HGNC:24036",
        "name": "APC regulator of Wnt signaling pathway 2",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/apc2"
      },
      {
        "slug": "asxl2",
        "symbol": "ASXL2",
        "hgnc": "HGNC:23805",
        "name": "ASXL transcriptional regulator 2",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/asxl2"
      },
      {
        "slug": "cyp19a1",
        "symbol": "CYP19A1",
        "hgnc": "HGNC:2594",
        "name": "cytochrome P450 family 19 subfamily A member 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cyp19a1"
      },
      {
        "slug": "gli3",
        "symbol": "GLI3",
        "hgnc": "HGNC:4319",
        "name": "GLI family zinc finger 3",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/gli3"
      },
      {
        "slug": "gnas",
        "symbol": "GNAS",
        "hgnc": "HGNC:4392",
        "name": "GNAS complex locus",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/gnas"
      },
      {
        "slug": "hsd11b1",
        "symbol": "HSD11B1",
        "hgnc": "HGNC:5208",
        "name": "hydroxysteroid 11-beta dehydrogenase 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/hsd11b1"
      },
      {
        "slug": "kmt2a",
        "symbol": "KMT2A",
        "hgnc": "HGNC:7132",
        "name": "lysine methyltransferase 2A",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/kmt2a"
      },
      {
        "slug": "lep",
        "symbol": "LEP",
        "hgnc": "HGNC:6553",
        "name": "leptin",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/lep"
      },
      {
        "slug": "lepr",
        "symbol": "LEPR",
        "hgnc": "HGNC:6554",
        "name": "leptin receptor",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/lepr"
      },
      {
        "slug": "mc4r",
        "symbol": "MC4R",
        "hgnc": "HGNC:6932",
        "name": "melanocortin 4 receptor",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mc4r"
      },
      {
        "slug": "prkg2",
        "symbol": "PRKG2",
        "hgnc": "HGNC:9416",
        "name": "protein kinase cGMP-dependent 2",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/prkg2"
      },
      {
        "slug": "ptch1",
        "symbol": "PTCH1",
        "hgnc": "HGNC:9585",
        "name": "patched 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ptch1"
      },
      {
        "slug": "slc26a2",
        "symbol": "SLC26A2",
        "hgnc": "HGNC:10994",
        "name": "solute carrier family 26 member 2",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/slc26a2"
      },
      {
        "slug": "ube3c",
        "symbol": "UBE3C",
        "hgnc": "HGNC:16803",
        "name": "ubiquitin protein ligase E3C",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ube3c"
      },
      {
        "slug": "abcc9",
        "symbol": "ABCC9",
        "hgnc": "HGNC:60",
        "name": "ATP binding cassette subfamily C member 9",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/abcc9"
      },
      {
        "slug": "alms1",
        "symbol": "ALMS1",
        "hgnc": "HGNC:428",
        "name": "ALMS1 centrosome and basal body associated protein",
        "frequency": "occasional",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/alms1"
      },
      {
        "slug": "arcn1",
        "symbol": "ARCN1",
        "hgnc": "HGNC:649",
        "name": "archain 1 coat protein complex I subunit delta",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/arcn1"
      },
      {
        "slug": "cavin1",
        "symbol": "CAVIN1",
        "hgnc": "HGNC:9688",
        "name": "caveolae associated protein 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cavin1"
      },
      {
        "slug": "ddx6",
        "symbol": "DDX6",
        "hgnc": "HGNC:2747",
        "name": "DEAD-box helicase 6",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ddx6"
      },
      {
        "slug": "gpc3",
        "symbol": "GPC3",
        "hgnc": "HGNC:4451",
        "name": "glypican 3",
        "frequency": "occasional",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/gpc3"
      },
      {
        "slug": "gpc4",
        "symbol": "GPC4",
        "hgnc": "HGNC:4452",
        "name": "glypican 4",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/gpc4"
      },
      {
        "slug": "gpx4",
        "symbol": "GPX4",
        "hgnc": "HGNC:4556",
        "name": "glutathione peroxidase 4",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/gpx4"
      },
      {
        "slug": "h1-4",
        "symbol": "H1-4",
        "hgnc": "HGNC:4718",
        "name": "H1.4 linker histone, cluster member",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/h1-4"
      },
      {
        "slug": "inppl1",
        "symbol": "INPPL1",
        "hgnc": "HGNC:6080",
        "name": "inositol polyphosphate phosphatase like 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/inppl1"
      },
      {
        "slug": "kcnj8",
        "symbol": "KCNJ8",
        "hgnc": "HGNC:6269",
        "name": "potassium inwardly rectifying channel subfamily J member 8",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/kcnj8"
      },
      {
        "slug": "rmrp",
        "symbol": "RMRP",
        "hgnc": "HGNC:10031",
        "name": "RNA component of mitochondrial RNA processing endoribonuclease",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rmrp"
      },
      {
        "slug": "rnf135",
        "symbol": "RNF135",
        "hgnc": "HGNC:21158",
        "name": "ring finger protein 135",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rnf135"
      },
      {
        "slug": "slc35d1",
        "symbol": "SLC35D1",
        "hgnc": "HGNC:20800",
        "name": "solute carrier family 35 member D1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/slc35d1"
      },
      {
        "slug": "smarca2",
        "symbol": "SMARCA2",
        "hgnc": "HGNC:11098",
        "name": "SWI/SNF related BAF chromatin remodeling complex subunit ATPase 2",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/smarca2"
      },
      {
        "slug": "tet3",
        "symbol": "TET3",
        "hgnc": "HGNC:28313",
        "name": "tet methylcytosine dioxygenase 3",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tet3"
      },
      {
        "slug": "b4galt7",
        "symbol": "B4GALT7",
        "hgnc": "HGNC:930",
        "name": "beta-1,4-galactosyltransferase 7",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/b4galt7"
      },
      {
        "slug": "agpat2",
        "symbol": "AGPAT2",
        "hgnc": "HGNC:325",
        "name": "1-acylglycerol-3-phosphate O-acyltransferase 2",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/agpat2"
      },
      {
        "slug": "b3gat3",
        "symbol": "B3GAT3",
        "hgnc": "HGNC:923",
        "name": "beta-1,3-glucuronyltransferase 3",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/b3gat3"
      },
      {
        "slug": "bscl2",
        "symbol": "BSCL2",
        "hgnc": "HGNC:15832",
        "name": "BSCL2 lipid droplet biogenesis associated, seipin",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/bscl2"
      },
      {
        "slug": "cdkn1c",
        "symbol": "CDKN1C",
        "hgnc": "HGNC:1786",
        "name": "cyclin dependent kinase inhibitor 1C",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cdkn1c"
      },
      {
        "slug": "chst3",
        "symbol": "CHST3",
        "hgnc": "HGNC:1971",
        "name": "carbohydrate sulfotransferase 3",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/chst3"
      },
      {
        "slug": "gpr101",
        "symbol": "GPR101",
        "hgnc": "HGNC:14963",
        "name": "G protein-coupled receptor 101",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/gpr101"
      },
      {
        "slug": "igf2",
        "symbol": "IGF2",
        "hgnc": "HGNC:5466",
        "name": "insulin like growth factor 2",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/igf2"
      },
      {
        "slug": "kcnq1",
        "symbol": "KCNQ1",
        "hgnc": "HGNC:6294",
        "name": "potassium voltage-gated channel subfamily Q member 1",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/kcnq1"
      },
      {
        "slug": "kcnq1ot1",
        "symbol": "KCNQ1OT1",
        "hgnc": "HGNC:6295",
        "name": "KCNQ1 opposite strand/antisense transcript 1",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/kcnq1ot1"
      },
      {
        "slug": "mc2r",
        "symbol": "MC2R",
        "hgnc": "HGNC:6930",
        "name": "melanocortin 2 receptor",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mc2r"
      },
      {
        "slug": "mkrn3",
        "symbol": "MKRN3",
        "hgnc": "HGNC:7114",
        "name": "makorin ring finger protein 3",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mkrn3"
      },
      {
        "slug": "slc10a7",
        "symbol": "SLC10A7",
        "hgnc": "HGNC:23088",
        "name": "solute carrier family 10 member 7",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/slc10a7"
      }
    ]
  }
}