Skip to content
Use your HSA or FSA funds

Gene

TDP2

tyrosyl-DNA phosphodiesterase 2

Summary

Cytogenetic location
6p22.3
Coordinates
Chromosome 6: 24,649,979–24,666,899 (GRCh38)
Exons
7 exons across 16.9 kb
Protein
362 amino acids
Inheritance
Autosomal recessive
Previous symbols
TTRAP
MANE Select transcript
ENST00000378198.9NM_016614.3
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated reports relevant to this gene

    • Autosomal Recessive Cerebellar Ataxias (incl. CANVAS and AVED)

      • Autosomal Recessive Cerebellar AtaxiaAutosomal recessive

        One of 57 genes linked to it

        A group of recessively inherited ataxias caused by biallelic variants in genes such as RFC1, FXN, SACS, TTPA, SETX, APTX, PNKP, ANO10 and SYNE1.

        • ClinGen rates the link definitive
        • 4 GenCC submitters rate it definitive or strong
        What knowing changes

        Ataxia with vitamin E deficiency (TTPA) is treatable with vitamin E supplements; other forms are managed with physiotherapy and symptom care, and relatives can be offered carrier testing.

    • Epilepsy (Full Panel)

      • Epilepsy

        One of 171 genes linked to it

        A brain disorder characterized by episodes of abnormally increased neuronal discharge resulting in transient episodes of sensory or motor neurological dysfunction, or psychic dysfunction. These episodes may or may not be associated with loss of consciousness or convulsions.

        • ClinGen rates the link definitive
        • 4 GenCC submitters rate it definitive or strong

    Inheritance

    Autosomal recessive
    It takes a changed copy from each parent. With one, you are a carrier and usually unaffected; when both parents are carriers, each child has a one-in-four chance of inheriting two.

    How TDP2 is laid out

    • Coding sequence
    • Untranslated region
    • Intron
    • Direction of transcription
    • Known disease-causing sites
    • Stretches short reads find hard
    Chromosome 6, with a bracket where TDP2 sits. TDP2 and 11 genes near it on chromosome 6, from 24,158,439 to 25,158,438.Chromosome 66p22.3p25.3p25.2p25.1p24.3p24.2p24.1p23p22.3p22.2p22.1p21.33p21.32p21.31p21.2p21.1p12.3p12.2p12.1p11.2p11.1q11.1q11.2q12q13q14.1q14.2q14.3q15q16.1q16.2q16.3q21q22.1q22.2q22.31q22.32q22.33q23.1q23.2q23.3q24.1q24.2q24.3q25.1q25.2q25.3q26q2724.2 Mb24.4 Mb24.6 Mb24.8 Mb25 MbDCDC2: 24,171,747–24,383,300, reverse strandDCDC2MRS2: 24,402,796–24,431,065, forward strandMRS2GPLD1: 24,418,076–24,495,205, reverse strandGPLD1ALDH5A1: 24,494,788–24,544,150, forward strandALDH5A1KIAA0319: 24,544,104–24,646,197, reverse strandKIAA0319TDP2: 24,649,979–24,666,899, reverse strandTDP2ACOT13: 24,666,901–24,714,084, forward strandACOT13C6orf62: 24,704,105–24,720,900, reverse strandC6orf62GMNN: 24,774,892–24,788,205, forward strandGMNNARMH2: 24,797,323–24,798,917, reverse strandARMH2: 24,797,373–24,809,798, reverse strandRIPOR2: 24,803,362–25,042,170, reverse strandRIPOR2Diagram of TDP2: 7 exons on the reverse strand of chromosome 6Exon 7: 1 known disease-causing siteExon 6: 1 known disease-causing siteExon 5: 1 known disease-causing siteExon 7: 24,649,979–24,651,069, 1,091 basesExon 6: 24,652,983–24,653,153, 171 basesExon 5: 24,654,412–24,654,530, 119 basesExon 4: 24,657,812–24,657,903, 92 basesExon 3: 24,658,561–24,658,734, 174 basesExon 2: 24,666,526–24,666,611, 86 basesExon 1: 24,666,698–24,666,899, 202 bases7515′3′

    Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

    Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

    Nearby genes from Ensembl release 116, on GRCh38.

    Exons make up 1.9 kb of the gene's 16.9 kb; 1,089 of those bases code for the protein.

    How a genome test reads TDP2

    5

    positions in TDP2 where ClinVar classes a change as pathogenic or likely pathogenic

    None of them falls in a region short reads find hard.

    A whole genome covers all 16.9 kb of TDP2, introns included, not only the 1.9 kb of exons.

    Where this comes from

    • HGNC: the gene's symbol, name, other symbols and location.
    • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
    • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
    • The ACMG secondary findings list, SF v3.2.
    • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
    • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
    • Data release 2026.10.16-c6eea6bf.

    Cite this page

    APA

    Dante Labs. (n.d.). TDP2 gene: tyrosyl-DNA phosphodiesterase 2. Retrieved 17 October 2026, from https://dantelabs.com/genes/tdp2

    Vancouver

    Dante Labs. TDP2 gene: tyrosyl-DNA phosphodiesterase 2 [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/tdp2

    One test. A lifetime of answers.

    From $449Free shipping · Results in 6–8 weeks

    Get my Genome Test