Gene
CFAP251
cilia and flagella associated protein 251
- HGNC 28506(opens in a new tab)
- Ensembl gene ENSG00000158023(opens in a new tab)
- NCBI Gene 144406(opens in a new tab)
Summary
- Cytogenetic location
- 12q24.31
- Coordinates
- Chromosome 12: 121,918,592–122,003,919 (GRCh38)
- Exons
- 22 exons across 85.3 kb
- Protein
- 1,149 amino acids
- Also known as
- MGC33630, CaM-IP4
- Previous symbols
- WDR66
- MANE Select transcript
- ENST00000288912.9NM_144668.6
- Locus type
- gene with protein product
- Very high
- Confident
- Low
- Very low
Reference genomeGRCh38hg38
Positions on gene and variant pages follow this choice, in this browser.
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Male Infertility
The inability of the male to effect fertilization of an ovum after a specified period of unprotected intercourse. Male sterility is permanent infertility.
- 1 GenCC submitter rates it definitive or strong
How CFAP251 is laid out
- Coding sequence
- Untranslated region
- Intron
- Direction of transcription
- Known disease-causing sites
- Stretches short reads find hard
Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.
Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).
Nearby genes from Ensembl release 116, on GRCh38.
Exons make up 3.7 kb of the gene's 85.3 kb; 3,450 of those bases code for the protein.
How a genome test reads CFAP251
9
positions in CFAP251 where ClinVar classes a change as pathogenic or likely pathogenic
None of them falls in a region short reads find hard.
A whole genome covers all 85.3 kb of CFAP251, introns included, not only the 3.7 kb of exons.
Traits linked to CFAP251
The Human Phenotype Ontology lists these as features of the rare conditions CFAP251 can cause. Each trait's page lists the other genes linked to it.
External links
Gene records
Transcript
Protein
Where this comes from
- HGNC: the gene's symbol, name, other symbols and location.
- MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
- GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
- The ACMG secondary findings list, SF v3.2.
- ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
- The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
Cite this page
Dante Labs. (n.d.). CFAP251 gene: cilia and flagella associated protein 251. Retrieved 16 October 2026, from https://dantelabs.com/genes/cfap251
Dante Labs. CFAP251 gene: cilia and flagella associated protein 251 [Internet]. [cited 16 October 2026]. Available from: https://dantelabs.com/genes/cfap251
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