Trait

Rounded lower back

Clinical name: Lumbar kyphosis

Over curvature of the lumbar region.

HPO HP:0008454

Also called: Lumbar gibbus deformity
Body system: Abnormality of the musculoskeletal system

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6 genes linked to Rounded lower back

Changes in these genes cause rare conditions in which Rounded lower back is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.

Gene	How often it is seen	Conditions
GALNSgalactosamine (N-acetyl)-6-sulfatase	Always	In 1 condition
POLR3GLRNA polymerase III subunit GL	Often (30–79%)	In 1 condition
AMNamnion associated transmembrane protein	Sometimes (5–29%)	In 1 condition
SLF2SMC5/6 complex localization factor 2	Sometimes (5–29%)	In 1 condition
VPS33AVPS33A core subunit of CORVET and HOPS complexes	Sometimes (5–29%)	In 1 condition
RPS6KA3ribosomal protein S6 kinase A3	Not recorded	In 1 condition

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Narrower traits

Broader traits

Abnormal lumbar spine morphology

Where this comes from

The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
Data release 2026.10.16-c6eea6bf.

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