Traits

Traits linked to SPP1

secreted phosphoprotein 1

The Human Phenotype Ontology links 80 traits to SPP1, by body system: features seen in people with one of the gene's rare conditions.

SPP1

Abnormality of the immune system

Trait	How often it is seen
Antinuclear antibody positivity	Very often (80–99%)
Decreased circulating complement C3 concentration	Very often (80–99%)
Decreased circulating complement C4 concentration	Very often (80–99%)
Anti-complement component C1q antibody positivity	Often (30–79%)
Anti-ribosome Po antibody positivity	Often (30–79%)
Anti-titin antibody positivity	Often (30–79%)
Antineutrophil antibody positivity	Often (30–79%)
Antiphospholipid antibody positivity	Often (30–79%)
Malar rash	Often (30–79%)
Skin rash	Often (30–79%)
Anti-dsDNA antibody positivity	Sometimes (5–29%)
Anti-La/SS-B antibody positivity	Sometimes (5–29%)
Anti-nucleoporin 62 antibody positivity	Sometimes (5–29%)
Anti-phosphatidic acid antibody positivity	Sometimes (5–29%)
Anti-Ro52/TRIM21 antibody positivity	Sometimes (5–29%)
Anti-Sm antibody positivity	Sometimes (5–29%)
Anti-U1 ribonucleoprotein antibody positivity	Sometimes (5–29%)
Discoid lupus rash	Sometimes (5–29%)
Lupus anticoagulant	Sometimes (5–29%)
Serositis	Sometimes (5–29%)
Systemic lupus erythematosus	Sometimes (5–29%)
Muscle inflammation	Rarely (1–4%)

Abnormality of the nervous system

Trait	How often it is seen
Abnormality of the nervous system	Sometimes (5–29%)
Depression	Sometimes (5–29%)
Disturbances of consciousness	Sometimes (5–29%)
Epilepsy	Sometimes (5–29%)
Headache	Sometimes (5–29%)
Paralysis on one side of body	Sometimes (5–29%)
Psychosis	Sometimes (5–29%)
Chorea	Rarely (1–4%)
Cognitive impairment	Rarely (1–4%)
Language impairment	Rarely (1–4%)

Laboratory abnormality

Trait	How often it is seen
Fever	Very often (80–99%)
High ESR	Very often (80–99%)
High urine protein levels	Very often (80–99%)
Blood in urine	Often (30–79%)
Fluid around lungs	Often (30–79%)
Fluid retention	Often (30–79%)
High urine neutrophil count	Often (30–79%)
Increased circulating lactate dehydrogenase concentration	Often (30–79%)
Dark urine	Sometimes (5–29%)

Abnormality of the digestive system

Trait	How often it is seen
Anorexia	Very often (80–99%)
Abnormality of the gastrointestinal tract	Often (30–79%)
Abdominal bloating	Sometimes (5–29%)
Abdominal pain	Sometimes (5–29%)
Accumulation of fluid in the abdomen	Sometimes (5–29%)
Vomiting	Sometimes (5–29%)
Diarrhea	Rarely (1–4%)

Abnormality of blood and blood-forming tissues

Trait	How often it is seen
Decreased blood leukocyte number	Often (30–79%)
Decreased blood lymphocyte number	Often (30–79%)
Low platelet count	Often (30–79%)
Microangiopathic hemolytic anemia	Often (30–79%)
Hemolytic anemia	Sometimes (5–29%)

Abnormality of the genitourinary system

Trait	How often it is seen
Kidney inflammation	Often (30–79%)
Lupus nephritis	Often (30–79%)
Nephrotic syndrome	Often (30–79%)
Renal failure	Often (30–79%)
Urinary tract abnormalities	Often (30–79%)

Abnormality of head or neck

Trait	How often it is seen
Abnormal color of the oral mucosa	Sometimes (5–29%)
Abnormality of salivation	Sometimes (5–29%)
Inflammation of the lips	Sometimes (5–29%)
Mouth sore	Sometimes (5–29%)

Abnormality of the cardiovascular system

Trait	How often it is seen
Fluid around heart	Often (30–79%)
High blood pressure	Often (30–79%)
Raynaud phenomenon	Often (30–79%)
Swollen lymph nodes	Often (30–79%)

Constitutional symptom

Trait	How often it is seen
Fatigue	Very often (80–99%)
Malaise	Very often (80–99%)
Joint pain	Sometimes (5–29%)
Chest pain	Rarely (1–4%)

Abnormality of the integument

Trait	How often it is seen
Abnormality of the skin	Often (30–79%)
Hair loss	Often (30–79%)
Photosensitive skin	Sometimes (5–29%)

Abnormality of the musculoskeletal system

Trait	How often it is seen
Arthritis	Often (30–79%)
Polyarticular arthritis	Often (30–79%)
Muscle weakness	Sometimes (5–29%)

Abnormality of the respiratory system

Trait	How often it is seen
Abnormality of the respiratory system	Sometimes (5–29%)
Breathing difficulty	Sometimes (5–29%)

Abnormality of the eye

Trait	How often it is seen
Noninflammatory retina disease	Rarely (1–4%)

Growth abnormality

Trait	How often it is seen
Weight loss	Very often (80–99%)

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Where this comes from

The Human Phenotype Ontology, release 2026-09-01: the traits linked to SPP1 and how often each is seen. Find out more at hpo.jax.org.

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