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Trait
Demyelinating peripheral neuropathy
Demyelinating neuropathy is characterized by slow nerve conduction velocities with reduced amplitudes of sensory/motor nerve conduction and prolonged distal latencies.
Summary
- Body system
- Abnormality of the nervous system
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page$trait$nameDemyelinating peripheral neuropathyHP:0007108
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Dante Labs condition reports look at the genes behind groups of inherited conditions, read from one whole-genome test. Each page says which conditions and genes a report covers, how it is read and what it cannot tell you.
- Aicardi-Goutieres SyndromeReads 8 of these genesADARIFIH1RNASEH2ARNASEH2BRNASEH2CRNU7-1About this report →
- Hereditary Optic NeuropathyReads 6 of these genesAFG3L2MT-ND1MT-ND4MT-ND5MT-ND6ACO2About this report →
- Rare Hereditary Peripheral NeuropathiesReads 25 of these genesITPR3ABHD12HARS1HK1NDRG1PMP22About this report →
- Rare Monogenic Autoinflammatory DiseasesReads 8 of these genesADARIFIH1RNASEH2ARNASEH2BRNASEH2CRNU7-1About this report →
Show 38 more reports
- Inherited Neurodegenerative DisordersReads 24 of these genesPLP1POLR3BAFG3L2POLGRFC1SACSAbout this report →
- Other Inherited LeukodystrophiesReads 11 of these genesPLP1POLR3BADARIFIH1RNASEH2ARNASEH2BAbout this report →
- Charcot-Marie-Tooth DiseaseReads 10 of these genesITPR3HARS1HK1NDRG1PMP22POLR3BAbout this report →
- Dyschromatosis Symmetrica HereditariaReads 1 of these genesADARAbout this report →
- Hereditary Neuropathy with Liability to Pressure Palsies (HNPP)Reads 1 of these genesPMP22About this report →
- POLR3B-Related DisorderReads 1 of these genesPOLR3BAbout this report →
- Leigh SyndromeReads 8 of these genesMT-ATP6MT-ND1MT-ND3MT-ND4MT-ND5MT-ND6About this report →
- DNA Repair DiseaseReads 6 of these genesERCC2ERCC3ERCC4ERCC5ERCC6ERCC8About this report →
- Other Inborn Errors of ImmunityReads 9 of these genesITPR3ADARIFIH1RNASEH2ARNASEH2BRNASEH2CAbout this report →
- Pelizaeus-Merzbacher Disease & Hypomyelinating LeukodystrophiesReads 3 of these genesPLP1POLR3BDEGS1About this report →
- Type I InterferonopathiesReads 2 of these genesIFIH1TREX1About this report →
- Moyamoya DiseaseReads 1 of these genesSAMHD1About this report →
- Primary Mitochondrial DiseaseReads 5 of these genesAFG3L2LIG3POLGRRM2BTYMPAbout this report →
- Systemic Lupus ErythematosusReads 1 of these genesTREX1About this report →
- Autosomal Recessive Cerebellar Ataxias (incl. CANVAS and AVED)Reads 3 of these genesRFC1SACSRNF168About this report →
- Microphthalmia, Anophthalmia & ColobomaReads 2 of these genesERCC2ERCC5About this report →
- Alpha-Mannosidosis and Other GlycoproteinosesReads 1 of these genesMANBAAbout this report →
- Waardenburg SyndromeReads 1 of these genesSOX10About this report →
- Pyruvate Kinase Deficiency and Other Red Cell Enzyme DisordersReads 1 of these genesHK1About this report →
- HyperinsulinismReads 1 of these genesHK1About this report →
- Usher SyndromeReads 1 of these genesHARS1About this report →
- LipodystrophyReads 1 of these genesPLAAT3About this report →
- Myofibrillar MyopathiesReads 1 of these genesBAG3About this report →
- Hereditary Spastic ParaplegiaReads 2 of these genesPLP1ZFYVE26About this report →
- Fanconi AnemiaReads 1 of these genesERCC4About this report →
- Autoimmune DiseaseReads 1 of these genesTREX1About this report →
- Hereditary Sensory and Autonomic Neuropathies (incl. Familial Dysautonomia)Reads 1 of these genesRFC1About this report →
- Pontocerebellar Hypoplasia (TSEN54 and MINPP1)Reads 1 of these genesVRK1About this report →
- Spinal Muscular AtrophyReads 1 of these genesVRK1About this report →
- Diabetes MellitusReads 1 of these genesMT-TL1About this report →
- Osteogenesis ImperfectaReads 1 of these genesIFIH1About this report →
- Autosomal Dominant Cerebellar Ataxias (SCAs and DRPLA)Reads 1 of these genesAFG3L2About this report →
- Dilated CardiomyopathyReads 1 of these genesBAG3About this report →
- Lysosomal Storage DiseaseReads 1 of these genesMANBAAbout this report →
- Retinitis PigmentosaReads 1 of these genesHK1About this report →
- Congenital Disorders of GlycosylationReads 1 of these genesMOGSAbout this report →
- Epilepsy (Full Panel)Reads 1 of these genesDMXL2About this report →
- Intellectual DisabilityReads 1 of these genesVRK1About this report →
Read the genes linked to Demyelinating peripheral neuropathy, and the rest of your genome, with one test.
From $449Free shipping · Results in 6–8 weeks
Get my Genome Test58 genes linked to Demyelinating peripheral neuropathy
Changes in these genes cause rare conditions in which Demyelinating peripheral neuropathy is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.
| Gene | How often it is seen | Conditions |
|---|---|---|
| ITPR3inositol 1,4,5-trisphosphate receptor type 3 | Always | In 1 condition |
| MOGSmannosyl-oligosaccharide glucosidase | Always | In 1 condition |
| PLAAT3phospholipase A and acyltransferase 3 | Always | In 1 condition |
| PTRH2peptidyl-tRNA hydrolase 2 | Always | In 1 condition |
| ABHD12abhydrolase domain containing 12, lysophospholipase | Very often (80–99%) | In 1 condition |
| HARS1histidyl-tRNA synthetase 1 | Very often (80–99%) | In 1 condition |
| HK1hexokinase 1 | Very often (80–99%) | In 1 condition |
| NDRG1N-myc downstream regulated 1 | Very often (80–99%) | In 1 condition |
| PLP1proteolipid protein 1 | Very often (80–99%) | In 1 condition |
| PMP22peripheral myelin protein 22 | Very often (80–99%) | In 2 conditions |
| POLR3BRNA polymerase III subunit B | Very often (80–99%) | In 1 condition |
| SH3TC2SH3 domain and tetratricopeptide repeats 2 | Very often (80–99%) | In 1 condition |
| AFG3L2AFG3 like matrix AAA peptidase subunit 2 | Often (30–79%) | In 1 condition |
| BAG3BAG cochaperone 3 | Often (30–79%) | In 1 condition |
| DMXL2Dmx like 2 | Often (30–79%) | In 1 condition |
| DNAJC3DnaJ heat shock protein family (Hsp40) member C3 | Often (30–79%) | In 1 condition |
| ERCC2ERCC excision repair 2, TFIIH core complex helicase subunit | Often (30–79%) | In 1 condition |
| ERCC3ERCC excision repair 3, TFIIH core complex helicase subunit | Often (30–79%) | In 1 condition |
| ERCC4ERCC excision repair 4, endonuclease catalytic subunit | Often (30–79%) | In 1 condition |
| ERCC5ERCC excision repair 5, endonuclease | Often (30–79%) | In 1 condition |
| ERCC6ERCC excision repair 6, chromatin remodeling factor | Often (30–79%) | In 1 condition |
| ERCC8ERCC excision repair 8, CSA ubiquitin ligase complex subunit | Often (30–79%) | In 1 condition |
| LIG3DNA ligase 3 | Often (30–79%) | In 1 condition |
| POLGDNA polymerase gamma, catalytic subunit | Often (30–79%) | In 1 condition |
| RFC1replication factor C subunit 1 | Often (30–79%) | In 1 condition |
| RRM2Bribonucleotide reductase regulatory TP53 inducible subunit M2B | Often (30–79%) | In 1 condition |
| SACSsacsin molecular chaperone | Often (30–79%) | In 1 condition |
| TYMPthymidine phosphorylase | Often (30–79%) | In 1 condition |
| VRK1VRK serine/threonine kinase 1 | Often (30–79%) | In 1 condition |
| ZFYVE26zinc finger FYVE-type containing 26 | Often (30–79%) | In 1 condition |
| ADARadenosine deaminase RNA specific | Sometimes (5–29%) | In 1 condition |
| GDAP1ganglioside induced differentiation associated protein 1 | Sometimes (5–29%) | In 1 condition |
| IFIH1interferon induced with helicase C domain 1 | Sometimes (5–29%) | In 1 condition |
| LSM11LSM11, U7 small nuclear RNA associated | Sometimes (5–29%) | In 1 condition |
| MANBAmannosidase beta | Sometimes (5–29%) | In 1 condition |
| MT-ATP6mitochondrially encoded ATP synthase membrane subunit 6 | Sometimes (5–29%) | In 1 condition |
| MT-ND1mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 1 | Sometimes (5–29%) | In 1 condition |
| MT-ND2mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 2 | Sometimes (5–29%) | In 1 condition |
| MT-ND3mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 3 | Sometimes (5–29%) | In 1 condition |
| MT-ND4mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 4 | Sometimes (5–29%) | In 1 condition |
Show 18 more genes
| Gene | How often it is seen | Conditions |
|---|---|---|
| MT-ND5mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 5 | Sometimes (5–29%) | In 1 condition |
| MT-ND6mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 6 | Sometimes (5–29%) | In 1 condition |
| MT-TKmitochondrially encoded tRNA-Lys (AAA/G) | Sometimes (5–29%) | In 1 condition |
| MT-TL1mitochondrially encoded tRNA-Leu (UUA/G) 1 | Sometimes (5–29%) | In 1 condition |
| MT-TVmitochondrially encoded tRNA-Val (GUN) | Sometimes (5–29%) | In 1 condition |
| MT-TWmitochondrially encoded tRNA-Trp (UGA/G) | Sometimes (5–29%) | In 1 condition |
| NRCAMneuronal cell adhesion molecule | Sometimes (5–29%) | In 1 condition |
| RNASEH2Aribonuclease H2 subunit A | Sometimes (5–29%) | In 1 condition |
| RNASEH2Bribonuclease H2 subunit B | Sometimes (5–29%) | In 1 condition |
| RNASEH2Cribonuclease H2 subunit C | Sometimes (5–29%) | In 1 condition |
| RNF168ring finger protein 168 | Sometimes (5–29%) | In 1 condition |
| RNU7-1RNA, U7 small nuclear 1 | Sometimes (5–29%) | In 1 condition |
| SAMHD1SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1 | Sometimes (5–29%) | In 1 condition |
| TREX1three prime repair exonuclease 1 | Sometimes (5–29%) | In 1 condition |
| DEGS1delta 4-desaturase, sphingolipid 1 | Rarely (1–4%) | In 1 condition |
| ACO2aconitase 2 | Not recorded | In 1 condition |
| SLC12A6solute carrier family 12 member 6 | Not recorded | In 1 condition |
| SOX10SRY-box transcription factor 10 | Not recorded | In 1 condition |
How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.
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Broader traits
Where this comes from
- The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
- Data release 2026.10.19-9814e911.
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