Trait
Elevated hemoglobin A1c
An increased concentration of hemoglobin A1c (HbA1c), which is the product of nonenzymatic attachment of a hexose molecule to the N-terminal amino acid of the hemoglobin molecule. This reaction is dependent on blood glucose concentration, and therefore reflects the mean glucose concentration over the previous 8 to 12 weeks. The HbA1c level provides a better indication of long-term glycemic control than one-time blood or urinary glucose measurements.
Summary
- Also called
- Elevated glycated haemoglobin, Elevated glycated hemoglobin, Elevated glycosylated haemoglobin, Elevated glycosylated hemoglobin, Elevated haemoglobin A1c, Elevated HbA1c, Increased HbA1c levels
Reference genomeGRCh38hg38
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Get my Genome Test29 genes linked to Elevated hemoglobin A1c
Changes in these genes cause rare conditions in which Elevated hemoglobin A1c is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.
| Gene | How often it is seen | Conditions |
|---|---|---|
| ABCC8ATP binding cassette subfamily C member 8 | Always | In 3 conditions |
| ALMS1ALMS1 centrosome and basal body associated protein | Always | In 1 condition |
| BLMBLM RecQ like helicase | Always | In 1 condition |
| BSCL2BSCL2 lipid droplet biogenesis associated, seipin | Always | In 1 condition |
| DMXL2Dmx like 2 | Always | In 1 condition |
| DNAJC3DnaJ heat shock protein family (Hsp40) member C3 | Always | In 1 condition |
| KCNJ11potassium inwardly rectifying channel subfamily J member 11 | Always | In 4 conditions |
| PAX4paired box 4 | Always | In 2 conditions |
| PLAAT3phospholipase A and acyltransferase 3 | Always | In 1 condition |
| RNU6ATACRNA, U6atac small nuclear | Always | In 1 condition |
| WRNWRN RecQ like helicase | Always | In 1 condition |
| YIPF5Yip1 domain family member 5 | Always | In 1 condition |
| NARS2asparaginyl-tRNA synthetase 2, mitochondrial | Very often (80–99%) | In 1 condition |
| APPL1adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1 | Often (30–79%) | In 2 conditions |
| BLKBLK proto-oncogene, Src family tyrosine kinase | Often (30–79%) | In 1 condition |
| CELcarboxyl ester lipase | Often (30–79%) | In 2 conditions |
| CELA2Achymotrypsin like elastase 2A | Often (30–79%) | In 1 condition |
| GCKglucokinase | Often (30–79%) | In 2 conditions |
| HNF1AHNF1 homeobox A | Often (30–79%) | In 1 condition |
| HNF4Ahepatocyte nuclear factor 4 alpha | Often (30–79%) | In 1 condition |
| INSinsulin | Often (30–79%) | In 2 conditions |
| KLF11KLF transcription factor 11 | Often (30–79%) | In 1 condition |
| LMNAlamin A/C | Often (30–79%) | In 1 condition |
| NEUROD1neuronal differentiation 1 | Often (30–79%) | In 1 condition |
| PDX1pancreatic and duodenal homeobox 1 | Often (30–79%) | In 1 condition |
| TRMT5tRNA methyltransferase 5 | Often (30–79%) | In 1 condition |
| MTX2metaxin 2 | Sometimes (5–29%) | In 1 condition |
| NSMCE2NSE2 SUMO ligase component of SMC5/6 complex | Not recorded | In 1 condition |
| SLC5A2solute carrier family 5 member 2 | Not recorded | In 1 condition |
How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.
Broader traits
Where this comes from
- The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
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