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Gene

RAPGEF4

Rap guanine nucleotide exchange factor 4

Summary

Cytogenetic location
2q31.1
Coordinates
Chromosome 2: 172,735,845–173,052,893 (GRCh38)
Exons
31 exons across 317 kb
Protein
1,011 amino acids
Also known as
cAMP-GEFII, CGEF2
MANE Select transcript
ENST00000397081.8NM_007023.4
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated reports relevant to this gene

No Genome Test report reads RAPGEF4 yet. The test sequences your whole genome, so your data includes it all the same.

How RAPGEF4 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Stretches short reads find hard
Chromosome 2, with a bracket where RAPGEF4 sits. RAPGEF4 and 4 genes near it on chromosome 2, from 172,394,369 to 173,394,368.Chromosome 22q31.1p25.3p25.2p25.1p24.3p24.2p24.1p23.3p23.2p23.1p22.3p22.2p22.1p21p16.3p16.2p16.1p15p14p13.3p13.2p13.1p12p11.2p11.1q11.1q11.2q12.1q12.2q12.3q13q14.1q14.2q14.3q21.1q21.2q21.3q22.1q22.2q22.3q23.1q23.2q23.3q24.1q24.2q24.3q31.1q31.2q31.3q32.1q32.2q32.3q33.1q33.2q33.3q34q35q36.1q36.2q36.3q37.1q37.2q37.3172.4 Mb172.6 Mb172.8 Mb173 Mb173.2 MbITGA6: 172,234,216–172,506,565, forward strandITGA6PDK1: 172,555,373–172,628,598, forward strandPDK1RAPGEF4: 172,735,845–173,052,893, forward strandRAPGEF4MAP3K20: 173,057,181–173,268,909, forward strandMAP3K20CDCA7: 173,354,818–173,368,997, forward strandCDCA7Diagram of RAPGEF4: 31 exons on the forward strand of chromosome 2Exon 1: 172,735,845–172,736,048, 204 basesExon 2: 172,795,025–172,795,167, 143 basesExon 3: 172,797,525–172,797,613, 89 basesExon 4: 172,814,279–172,814,425, 147 basesExon 5: 172,917,802–172,917,874, 73 basesExon 6: 172,922,281–172,922,300, 20 basesExon 7: 172,960,760–172,960,813, 54 basesExon 8: 172,961,122–172,961,228, 107 basesExon 9: 172,965,562–172,965,683, 122 basesExon 10: 172,967,261–172,967,444, 184 basesExon 11: 172,983,496–172,983,580, 85 basesExon 12: 172,985,433–172,985,493, 61 basesExon 13: 172,988,196–172,988,272, 77 basesExon 14: 172,988,693–172,988,839, 147 basesExon 15: 172,990,810–172,990,925, 116 basesExon 16: 172,996,466–172,996,554, 89 basesExon 17: 173,001,266–173,001,344, 79 basesExon 18: 173,014,464–173,014,614, 151 basesExon 19: 173,016,349–173,016,437, 89 basesExon 20: 173,017,174–173,017,204, 31 basesExon 21: 173,017,426–173,017,504, 79 basesExon 22: 173,018,656–173,018,802, 147 basesExon 23: 173,020,618–173,020,715, 98 basesExon 24: 173,026,572–173,026,697, 126 basesExon 25: 173,027,081–173,027,259, 179 basesExon 26: 173,030,164–173,030,254, 91 basesExon 27: 173,033,914–173,033,964, 51 basesExon 28: 173,036,125–173,036,212, 88 basesExon 29: 173,036,628–173,036,692, 65 basesExon 30: 173,048,600–173,048,654, 55 basesExon 31: 173,051,640–173,052,893, 1,254 bases120315′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 4.3 kb of the gene's 317 kb; 3,036 of those bases code for the protein.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.

Cite this page

APA

Dante Labs. (n.d.). RAPGEF4 gene: Rap guanine nucleotide exchange factor 4. Retrieved 17 October 2026, from https://dantelabs.com/genes/rapgef4

Vancouver

Dante Labs. RAPGEF4 gene: Rap guanine nucleotide exchange factor 4 [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/rapgef4

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