Traits

Traits linked to CASP10

caspase 10

The Human Phenotype Ontology links 90 traits to CASP10, by body system: features seen in people with one of the gene's rare conditions.

Abnormality of blood and blood-forming tissues

Trait	How often it is seen
Autoimmune hemolytic anemia	Always
Coombs-positive hemolytic anemia	Always
Increased double-negative T cell number	Always
Autoimmune neutropenia	Often (30–79%)
Autoimmune thrombocytopenia	Often (30–79%)
Bleeding tendency	Often (30–79%)
Bruising susceptibility	Often (30–79%)
Increased total B cell count	Often (30–79%)
Abnormal CD4+ T cell subset proportion	Sometimes (5–29%)
Abnormal total CD8+ T cell number	Sometimes (5–29%)
B-cell lymphoma	Sometimes (5–29%)
Burkitt lymphoma	Sometimes (5–29%)
Decreased blood lymphocyte number	Sometimes (5–29%)
Decreased total CD4+ T cell proportion	Sometimes (5–29%)
High blood eosinophil count	Sometimes (5–29%)
High lymphocyte count	Sometimes (5–29%)
Hodgkin lymphoma	Sometimes (5–29%)
Increased immature red blood cells	Sometimes (5–29%)
Non-Hodgkin lymphoma	Sometimes (5–29%)
T-cell lymphoma	Sometimes (5–29%)
Bone marrow failure	Rarely (1–4%)
Bone marrow hypercellularity	Rarely (1–4%)
Cancer of lymphatic system	Not recorded
Gastrointestinal bleeding	Not recorded
Increased HLA-DR+ CD4+ T cell proportion	Not recorded
Iron deficiency anemia	Not recorded
Low platelet count	Not recorded
Petechiae	Not recorded

Abnormality of the immune system

Trait	How often it is seen
Rheumatoid factor positive	Always
Autoimmunity	Very often (80–99%)
Abnormal circulating interleukin concentration	Often (30–79%)
Increased circulating interleukin 10 concentration	Often (30–79%)
Antineutrophil antibody positivity	Sometimes (5–29%)
Antinuclear antibody positivity	Sometimes (5–29%)
Antiphospholipid antibody positivity	Sometimes (5–29%)
Decreased specific anti-polysaccharide antibody concentration	Sometimes (5–29%)
Increased circulating interleukin 18 concentration	Sometimes (5–29%)
Inflammation of fat tissue	Rarely (1–4%)
Systemic lupus erythematosus	Rarely (1–4%)
Anti-smooth muscle antibody positivity	Not recorded
Malar rash	Not recorded
Platelet antibody positive	Not recorded

Abnormal cellular phenotype

Trait	How often it is seen
Abnormal T cell apoptosis	Often (30–79%)
Increased antibody level in blood	Often (30–79%)
Increased circulating IgG concentration	Often (30–79%)
Decreased circulating IgG concentration	Sometimes (5–29%)
Decreased circulating IgM concentration	Sometimes (5–29%)
Increased circulating IgA concentration	Sometimes (5–29%)
Increased circulating IgE concentration	Sometimes (5–29%)
Decreased T cell apoptosis	Not recorded
Increased circulating IgM concentration	Not recorded
Reduced delayed hypersensitivity	Not recorded

Abnormality of the cardiovascular system

Trait	How often it is seen
Increased spleen size	Always
Swollen lymph nodes	Always
Chronic noninfectious lymphadenopathy	Very often (80–99%)
Hypersplenism	Often (30–79%)
Hives	Sometimes (5–29%)
Inflammation of blood vessel	Sometimes (5–29%)
Follicular hyperplasia	Not recorded

Abnormality of the digestive system

Trait	How often it is seen
Enlarged liver	Always
Liver inflammation	Sometimes (5–29%)
Colitis	Rarely (1–4%)
Hepatocellular carcinoma	Rarely (1–4%)
Stomach inflammation	Rarely (1–4%)
Stomach cancer	Not recorded

Laboratory abnormality

Trait	How often it is seen
High ESR	Always
Abnormal vitamin B12 concentration	Sometimes (5–29%)
Elevated circulating sFASL concentration	Sometimes (5–29%)
Elevated circulating vitamin B12 concentration	Sometimes (5–29%)
Hydrops fetalis	Rarely (1–4%)
Increased level of L-fucose in urine	Not recorded

Abnormality of the genitourinary system

Trait	How often it is seen
Glomerulonephritis	Sometimes (5–29%)
Early menopause	Rarely (1–4%)
Renal failure	Rarely (1–4%)
Kidney inflammation	Not recorded
Nephrotic syndrome	Not recorded

Abnormality of the endocrine system

Trait	How often it is seen
Thyroid gland inflammation	Sometimes (5–29%)
Thyroid adenoma	Rarely (1–4%)
Thyroid carcinoma	Rarely (1–4%)

Abnormality of head or neck

Trait	How often it is seen
Neoplasm of the tongue	Rarely (1–4%)
Recurrent canker sores	Rarely (1–4%)

Abnormality of the integument

Trait	How often it is seen
Basal cell carcinoma	Rarely (1–4%)
Skin cancer	Rarely (1–4%)

Abnormality of the nervous system

Trait	How often it is seen
Epilepsy	Rarely (1–4%)
Headache	Rarely (1–4%)

Abnormality of the respiratory system

Trait	How often it is seen
Lung infiltrates	Rarely (1–4%)
Pulmonary scarring	Rarely (1–4%)

Abnormality of the breast

Trait	How often it is seen
Fibroadenoma of the breast	Rarely (1–4%)

Abnormality of the eye

Trait	How often it is seen
Uveitis	Rarely (1–4%)

Abnormality of the musculoskeletal system

Trait	How often it is seen
Arthritis	Rarely (1–4%)

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Where this comes from

The Human Phenotype Ontology, release 2026-09-01: the traits linked to CASP10 and how often each is seen. Find out more at hpo.jax.org.

One test. A lifetime of answers.

From $449Free shipping · Results in 6–8 weeks

Get my Genome Test