Trait
Lower limb pain
An unpleasant sensation characterized by physical discomfort (such as pricking, throbbing, or aching) localized to the leg.
Summary
- Also called
- Leg pain
Reference genomeGRCh38hg38
Positions on gene and variant pages follow this choice, in this browser.
Read the genes linked to Lower limb pain, and the rest of your genome, with one test.
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Get my Genome Test22 genes linked to Lower limb pain
Changes in these genes cause rare conditions in which Lower limb pain is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.
| Gene | How often it is seen | Conditions |
|---|---|---|
| FDXRferredoxin reductase | Always | In 1 condition |
| HEPHL1hephaestin like 1 | Always | In 1 condition |
| NAGLUN-acetyl-alpha-glucosaminidase | Always | In 1 condition |
| SCN4Asodium voltage-gated channel alpha subunit 4 | Always | In 1 condition |
| SCO2synthesis of cytochrome C oxidase 2 | Always | In 1 condition |
| TGFB1transforming growth factor beta 1 | Always | In 1 condition |
| KRT16keratin 16 | Very often (80–99%) | In 1 condition |
| KRT17keratin 17 | Very often (80–99%) | In 1 condition |
| KRT6Akeratin 6A | Very often (80–99%) | In 1 condition |
| KRT6Bkeratin 6B | Very often (80–99%) | In 1 condition |
| MT-ATP6mitochondrially encoded ATP synthase membrane subunit 6 | Very often (80–99%) | In 1 condition |
| HTRA1HtrA serine peptidase 1 | Often (30–79%) | In 1 condition |
| MT-TKmitochondrially encoded tRNA-Lys (AAA/G) | Often (30–79%) | In 1 condition |
| NLRP12NLR family pyrin domain containing 12 | Often (30–79%) | In 1 condition |
| PRKRAprotein activator of interferon induced protein kinase EIF2AK2 | Often (30–79%) | In 2 conditions |
| ACP5acid phosphatase 5, tartrate resistant | Sometimes (5–29%) | In 1 condition |
| ALDH18A1aldehyde dehydrogenase 18 family member A1 | Sometimes (5–29%) | In 1 condition |
| ERLIN1ER lipid raft associated 1 | Sometimes (5–29%) | In 1 condition |
| MMEmembrane metalloendopeptidase | Sometimes (5–29%) | In 1 condition |
| RASA1RAS p21 protein activator 1 | Sometimes (5–29%) | In 1 condition |
| SPG7SPG7 matrix AAA peptidase subunit, paraplegin | Rarely (1–4%) | In 1 condition |
| TGFB2transforming growth factor beta 2 | Not recorded | In 1 condition |
How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.
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Where this comes from
- The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
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