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Gene

HOXA11

homeobox A11

Summary

Cytogenetic location
7p15.2
Coordinates
Chromosome 7: 27,181,157–27,185,232 (GRCh38)
Exons
2 exons across 4.1 kb
Protein
313 amino acids
Previous symbols
HOX1I, HOX1
MANE Select transcript
ENST00000006015.4NM_005523.6
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated report relevant to this gene

  • Inherited Thrombocytopenias

    • Inherited Thrombocytopenia

      A group of conditions causing a lifelong low platelet count, linked to genes such as MYH9, ANKRD26, ETV6, WAS, MPL, RBM8A, GATA1 and MECOM, and inherited in dominant, recessive or X-linked patterns.

      • 1 GenCC submitter rates it definitive or strong
      What knowing changes

      A genetic diagnosis avoids misdiagnosis as immune thrombocytopenia, with unnecessary steroids or spleen removal, and guides monitoring for related kidney, hearing or blood problems.

How HOXA11 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
Chromosome 7, with a bracket where HOXA11 sits. HOXA11 and 14 genes near it on chromosome 7, from 26,683,195 to 27,683,194.Chromosome 77p15.2p22.3p22.2p22.1p21.3p21.2p21.1p15.3p15.2p15.1p14.3p14.2p14.1p13p12.3p12.2p12.1p11.2p11.1q11.1q11.21q11.22q11.23q21.11q21.12q21.13q21.2q21.3q22.1q22.2q22.3q31.1q31.2q31.31q31.32q31.33q32.1q32.2q32.3q33q34q35q36.1q36.2q36.326.8 Mb27 Mb27.2 Mb27.4 Mb27.6 MbSKAP2: 26,667,003–26,995,239, reverse strandSKAP2HOXA1: 27,092,993–27,096,039, reverse strandHOXA1HOXA2: 27,099,978–27,102,686, reverse strandHOXA2HOXA3: 27,106,184–27,152,610, reverse strandHOXA4: 27,127,887–27,130,780, reverse strandHOXA5: 27,141,052–27,143,719, reverse strandHOXA6: 27,144,103–27,150,603, reverse strandHOXA7: 27,153,716–27,157,936, reverse strandHOXA10-HOXA9: 27,162,438–27,180,239, reverse strandHOXA10-HOXA9HOXA9: 27,162,438–27,175,180, reverse strandHOXA10: 27,170,592–27,180,261, reverse strandHOXA10HOXA11: 27,181,157–27,185,232, reverse strandHOXA11HOXA13: 27,193,503–27,200,091, reverse strandHOXA13EVX1: 27,242,700–27,250,493, forward strandEVX1HIBADH: 27,486,365–27,663,013, reverse strandHIBADHDiagram of HOXA11: 2 exons on the reverse strand of chromosome 7Exon 2: 27,181,157–27,183,028, 1,872 basesExon 1: 27,184,436–27,185,232, 797 bases215′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 2.7 kb of the gene's 4.1 kb; 942 of those bases code for the protein.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). HOXA11 gene: homeobox A11. Retrieved 17 October 2026, from https://dantelabs.com/genes/hoxa11

Vancouver

Dante Labs. HOXA11 gene: homeobox A11 [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/hoxa11

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