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Gene

CCDC88C

coiled-coil and HOOK domain protein 88C

Summary

Cytogenetic location
14q32.11-q32.12
Coordinates
Chromosome 14: 91,271,323–91,417,820 (GRCh38)
Exons
30 exons across 146.5 kb
Protein
2,028 amino acids
Also known as
DAPLE, HkRP2, SCA40
Previous symbols
KIAA1509
MANE Select transcript
ENST00000389857.11NM_001080414.4
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Curated reports relevant to this gene

No Genome Test report reads CCDC88C yet. The test sequences your whole genome, so your data includes it all the same.

How CCDC88C is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 14, with a bracket where CCDC88C sits. CCDC88C and 6 genes near it on chromosome 14, from 90,844,572 to 91,844,571.Chromosome 1414q32.11-q32.12p13p12p11.2p11.1q11.1q11.2q12q13.1q13.2q13.3q21.1q21.2q21.3q22.1q22.2q22.3q23.1q23.2q23.3q24.1q24.2q24.3q31.1q31.2q31.3q32.11q32.12q32.13q32.2q32.31q32.32q32.3391 Mb91.2 Mb91.4 Mb91.6 Mb91.8 MbRPS6KA5: 90,847,861–91,060,685, reverse strandRPS6KA5DGLUCY: 91,060,044–91,226,930, forward strandDGLUCYGPR68: 91,232,530–91,264,777, reverse strandGPR68CCDC88C: 91,271,323–91,417,820, reverse strandCCDC88CPPP4R3A: 91,457,139–91,510,556, reverse strandPPP4R3ACATSPERB: 91,580,696–91,780,707, reverse strandCATSPERBTC2N: 91,779,746–91,867,536, reverse strandTC2NDiagram of CCDC88C: 30 exons on the reverse strand of chromosome 14Exon 30: 8 known disease-causing sitesExon 29: 1 known disease-causing siteExon 28: 1 known disease-causing siteExon 27: 1 known disease-causing siteExon 26: 2 known disease-causing sitesExon 25: 1 known disease-causing siteExon 24: 2 known disease-causing sitesExon 23: 5 known disease-causing sitesExon 22: 4 known disease-causing sitesExon 21: 3 known disease-causing sitesExon 20: 12 known disease-causing sitesExon 19: 6 known disease-causing sitesExon 18: 7 known disease-causing sitesExon 17: 4 known disease-causing sitesExon 16: 1 known disease-causing siteExon 15: 13 known disease-causing sitesExon 14: 4 known disease-causing sitesExon 13: 5 known disease-causing sitesExon 12: 3 known disease-causing sitesExon 11: 3 known disease-causing sitesExon 10: 1 known disease-causing siteExon 9: 2 known disease-causing sitesExon 8: 1 known disease-causing siteExon 7: 2 known disease-causing sitesExon 6: 2 known disease-causing sitesExon 3: 1 known disease-causing siteExon 2: 4 known disease-causing sitesExon 30: 91,271,323–91,273,653, 2,331 basesExon 29: 91,277,922–91,278,211, 290 basesExon 28: 91,279,238–91,279,306, 69 basesExon 27: 91,281,457–91,281,525, 69 basesExon 26: 91,283,329–91,283,517, 189 basesExon 25: 91,289,105–91,289,343, 239 basesExon 24: 91,290,995–91,291,084, 90 basesExon 23: 91,294,173–91,294,318, 146 basesExon 22: 91,297,305–91,297,491, 187 basesExon 21: 91,299,927–91,300,070, 144 basesExon 20: 91,303,701–91,303,978, 278 basesExon 19: 91,305,765–91,305,926, 162 basesExon 18: 91,307,038–91,307,226, 189 basesExon 17: 91,308,351–91,308,492, 142 basesExon 16: 91,309,859–91,309,986, 128 basesExon 15: 91,313,080–91,314,150, 1,071 basesExon 14: 91,315,650–91,315,787, 138 basesExon 13: 91,321,120–91,321,304, 185 basesExon 12: 91,324,779–91,324,923, 145 basesExon 11: 91,325,910–91,326,056, 147 basesExon 10: 91,338,005–91,338,163, 159 basesExon 9: 91,338,489–91,338,570, 82 basesExon 8: 91,339,278–91,339,462, 185 basesExon 7: 91,339,884–91,340,024, 141 basesExon 6: 91,342,380–91,342,463, 84 basesExon 5: 91,343,599–91,343,657, 59 basesExon 4: 91,359,642–91,359,711, 70 basesExon 3: 91,408,659–91,408,767, 109 basesExon 2: 91,416,738–91,416,838, 101 basesExon 1: 91,417,631–91,417,820, 190 bases3025201510515′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 7.5 kb of the gene's 146.5 kb; 6,087 of those bases code for the protein.

How a genome test reads CCDC88C

107

positions in CCDC88C where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 146.5 kb of CCDC88C, introns included, not only the 7.5 kb of exons.

Traits linked to CCDC88C

The Human Phenotype Ontology lists these as features of the rare conditions CCDC88C can cause. Each trait's page lists the other genes linked to it.

External links

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). CCDC88C gene: coiled-coil and HOOK domain protein 88C. Retrieved 17 October 2026, from https://dantelabs.com/genes/ccdc88c

Vancouver

Dante Labs. CCDC88C gene: coiled-coil and HOOK domain protein 88C [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/ccdc88c

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