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Trait
Clonus
A series of rhythmic and involuntary muscle contractions (at a frequency of about 5 to 7 Hz) that occur in response to an abruptly applied and sustained stretch.
Summary
- Also called
- Involuntary rhythmic muscular contractions and relaxations
- Body system
- Abnormality of the nervous system
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This page as data
Add .json to the page's address, or ask for application/json, to read it as JSON.
library(jsonlite)
url <- "https://dantelabs.com/traits/clonus.json"
page <- fromJSON(url)
page$trait$nameClonusHP:0002169
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Get my Genome Test67 condition reports read genes linked to this trait
Dante Labs condition reports look at the genes behind groups of inherited conditions, read from one whole-genome test. Each page says which conditions and genes a report covers, how it is read and what it cannot tell you.
- Inherited Neurodegenerative DisordersReads 33 of these genesABCB7DNM1LNADK2TANGO2TSEN2ALS2About this report →
- Amyotrophic Lateral Sclerosis (ALS)Reads 9 of these genesALS2FUSSETXSIGMAR1SPG11SPTLC1About this report →
- Hereditary Spastic ParaplegiaReads 10 of these genesKIF1CRTN2UBAP1ATP13A2ERLIN1KPNA3About this report →
- Congenital Muscular DystrophiesReads 6 of these genesFKRPGMPPBPOMGNT1POMKPOMT1POMT2About this report →
Show 63 more reports
- 3-Methylglutaconic Aciduria Type 8 (HTRA2)Reads 1 of these genesHTRA2About this report →
- 3-Methylglutaconic Aciduria Type 9 (TIMM50)Reads 1 of these genesTIMM50About this report →
- Asparagine Synthetase DeficiencyReads 1 of these genesASNSAbout this report →
- BRAT1-Related Neurodevelopmental Disorder with Cerebellar AtrophyReads 1 of these genesBRAT1About this report →
- EBF3-Related Neurodevelopmental Disorder (HADDS)Reads 1 of these genesEBF3About this report →
- Huntington DiseaseReads 1 of these genesHTTAbout this report →
- KCNQ2-Related Neonatal Encephalopathy with Non-Epileptic MyoclonusReads 1 of these genesKCNQ2About this report →
- KDM1A-Related Neurodevelopmental DisorderReads 1 of these genesKDM1AAbout this report →
- Primary Microcephaly 26 (LMNB1)Reads 1 of these genesLMNB1About this report →
- SPTBN1-Related Neurodevelopmental DisorderReads 1 of these genesSPTBN1About this report →
- Charcot-Marie-Tooth DiseaseReads 7 of these genesEMILIN1RTN2PRPS1SETXSIGMAR1SORDAbout this report →
- Spinal Muscular AtrophyReads 4 of these genesTSEN2EMILIN1SIGMAR1SEPSECSAbout this report →
- Rare Hereditary Peripheral NeuropathiesReads 11 of these genesEMILIN1RTN2PET100PEX16PRPS1SETXAbout this report →
- Disorders of Glycine & Serine MetabolismReads 2 of these genesSLC1A4SLC6A9About this report →
- Cerebral Arteriopathy with Subcortical Infarcts and LeukoencephalopathyReads 1 of these genesNOTCH3About this report →
- Dent Disease and Lowe SyndromeReads 1 of these genesOCRLAbout this report →
- Encephalopathy due to Mitochondrial and Peroxisomal Fission DefectReads 1 of these genesDNM1LAbout this report →
- Pontocerebellar Hypoplasia (TSEN54 and MINPP1)Reads 3 of these genesTSEN2AMPD2SEPSECSAbout this report →
- Congenital Disorders of GlycosylationReads 6 of these genesFKRPGMPPBGNEPOMGNT1POMT1POMT2About this report →
- Thyroid Hormone Resistance, Transport & Metabolism DefectsReads 1 of these genesSLC16A2About this report →
- Limb-Girdle Muscular DystrophyReads 3 of these genesFKRPGMPPBPOMGNT1About this report →
- Epilepsy (Full Panel)Reads 7 of these genesDNM1KCNQ2KCNQ3BRAT1KCNT1PIGPAbout this report →
- Adult-Onset Leukodystrophies (CSF1R, LMNB1, Nasu-Hakola)Reads 1 of these genesLMNB1About this report →
- Overgrowth Syndromes (Sotos, Weaver, Tatton-Brown-Rahman, Malan)Reads 1 of these genesNSD1About this report →
- Other Inherited LeukodystrophiesReads 4 of these genesNADK2LMNB1PEX16HIKESHIAbout this report →
- Hereditary Sensory and Autonomic Neuropathies (incl. Familial Dysautonomia)Reads 2 of these genesSPTLC1SPTLC2About this report →
- Heritable Pulmonary Arterial Hypertension (HPAH)Reads 1 of these genesCAV1About this report →
- Hereditary Sideroblastic AnaemiasReads 1 of these genesABCB7About this report →
- Purine & Pyrimidine Metabolism DisordersReads 1 of these genesPRPS1About this report →
- Anterior Segment Dysgenesis, Axenfeld-Rieger Syndrome & AniridiaReads 1 of these genesITPR1About this report →
- Imprinting Disorders: Prader-Willi, Silver-Russell and Beckwith-WiedemannReads 1 of these genesNSD1About this report →
- Pyruvate Dehydrogenase & Pyruvate Carboxylase DeficiencyReads 1 of these genesPCAbout this report →
- Neurodegeneration with Brain Iron Accumulation (NBIA)Reads 1 of these genesATP13A2About this report →
- BH4 Deficiency & Monoamine Neurotransmitter DisordersReads 1 of these genesPTSAbout this report →
- LipodystrophyReads 1 of these genesCAV1About this report →
- Urea Cycle DisorderReads 1 of these genesSLC25A15About this report →
- Hereditary Optic NeuropathyReads 1 of these genesDNM1LAbout this report →
- Neuronal Ceroid LipofuscinosisReads 1 of these genesATP13A2About this report →
- OsteopetrosisReads 1 of these genesOSTM1About this report →
- Zellweger Spectrum & Peroxisome Biogenesis DisordersReads 1 of these genesPEX16About this report →
- Autosomal Recessive Cerebellar Ataxias (incl. CANVAS and AVED)Reads 2 of these genesSETXSYNE1About this report →
- Parkinson DiseaseReads 1 of these genesATP13A2About this report →
- Hypertrophic CardiomyopathyReads 2 of these genesMYL2NSD1About this report →
- Cutis LaxaReads 1 of these genesEMILIN1About this report →
- Distal MyopathiesReads 1 of these genesGNEAbout this report →
- GPI Anchor Biosynthesis DefectsReads 1 of these genesPIGPAbout this report →
- Lissencephaly Spectrum DisordersReads 1 of these genesRAB3GAP2About this report →
- Syndromic Complex Neurodevelopmental DisorderReads 1 of these genesRNU4-2About this report →
- Pelizaeus-Merzbacher Disease & Hypomyelinating LeukodystrophiesReads 1 of these genesHIKESHIAbout this report →
- Congenital Myasthenic SyndromeReads 1 of these genesGMPPBAbout this report →
- VitreoretinopathyReads 1 of these genesNDPAbout this report →
- Microphthalmia, Anophthalmia & ColobomaReads 1 of these genesRAB3GAP2About this report →
- Inherited ThrombocytopeniasReads 1 of these genesGNEAbout this report →
- Primary Mitochondrial DiseaseReads 2 of these genesPET100RNASEH1About this report →
- Autosomal Dominant Cerebellar Ataxias (SCAs and DRPLA)Reads 1 of these genesITPR1About this report →
- DNA Repair DiseaseReads 1 of these genesSETXAbout this report →
- Dilated CardiomyopathyReads 1 of these genesSYNE1About this report →
- Hypogonadotropic HypogonadismReads 1 of these genesRAB3GAP2About this report →
- Intellectual DisabilityReads 2 of these genesRUSC2SLC16A2About this report →
- Lysosomal Storage DiseaseReads 1 of these genesGNEAbout this report →
- Leigh SyndromeReads 1 of these genesPET100About this report →
- Retinitis PigmentosaReads 1 of these genesPOMGNT1About this report →
- Hearing Loss and DeafnessReads 1 of these genesPRPS1About this report →
Read the genes linked to Clonus, and the rest of your genome, with one test.
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Get my Genome Test98 genes linked to Clonus
Changes in these genes cause rare conditions in which Clonus is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.
| Gene | How often it is seen | Conditions |
|---|---|---|
| ABCB7ATP binding cassette subfamily B member 7 | Always | In 1 condition |
| CAMLGcalcium modulating ligand | Always | In 1 condition |
| CCT5chaperonin containing TCP1 subunit 5 | Always | In 2 conditions |
| DNM1dynamin 1 | Always | In 1 condition |
| DNM1Ldynamin 1L | Always | In 1 condition |
| GOLGA2golgin A2 | Always | In 1 condition |
| GTF3C3general transcription factor IIIC subunit 3 | Always | In 1 condition |
| KLC4kinesin light chain 4 | Always | In 1 condition |
| MED17mediator complex subunit 17 | Always | In 1 condition |
| MICU1mitochondrial calcium uptake 1 | Always | In 1 condition |
| MSL2MSL complex subunit 2 | Always | In 1 condition |
| MYL2myosin light chain 2 | Always | In 1 condition |
| NADK2NAD kinase 2, mitochondrial | Always | In 1 condition |
| NFU1NFU1 iron-sulfur cluster scaffold | Always | In 1 condition |
| NSD1nuclear receptor binding SET domain protein 1 | Always | In 1 condition |
| PGBD5piggyBac transposable element derived 5 | Always | In 1 condition |
| RAB3GAP2RAB3 GTPase activating non-catalytic protein subunit 2 | Always | In 1 condition |
| SEL1LSEL1L adaptor subunit of SYVN1 ubiquitin ligase | Always | In 1 condition |
| SLC25A21solute carrier family 25 member 21 | Always | In 1 condition |
| TANGO2transport and golgi organization 2 homolog | Always | In 2 conditions |
| TSEN2tRNA splicing endonuclease subunit 2 | Always | In 1 condition |
| WDR83OSWD repeat domain 83 opposite strand | Always | In 1 condition |
| TIMM50translocase of inner mitochondrial membrane 50 | Very often (80–99%) | In 2 conditions |
| VPS37AVPS37A subunit of ESCRT-I | Very often (80–99%) | In 2 conditions |
| ALS2alsin Rho guanine nucleotide exchange factor ALS2 | Often (30–79%) | In 2 conditions |
| AMPD2adenosine monophosphate deaminase 2 | Often (30–79%) | In 2 conditions |
| ASNSasparagine synthetase (glutamine-hydrolyzing) | Often (30–79%) | In 1 condition |
| DTYMKdeoxythymidylate kinase | Often (30–79%) | In 1 condition |
| ELFN1extracellular leucine rich repeat and fibronectin type III domain containing 1 | Often (30–79%) | In 1 condition |
| EMILIN1elastin microfibril interfacer 1 | Often (30–79%) | In 1 condition |
| EXTL3exostosin like glycosyltransferase 3 | Often (30–79%) | In 1 condition |
| ITPR1inositol 1,4,5-trisphosphate receptor type 1 | Often (30–79%) | In 1 condition |
| KCNQ2potassium voltage-gated channel subfamily Q member 2 | Often (30–79%) | In 1 condition |
| KCNQ3potassium voltage-gated channel subfamily Q member 3 | Often (30–79%) | In 1 condition |
| KIF1Ckinesin family member 1C | Often (30–79%) | In 1 condition |
| NOTCH3notch receptor 3 | Often (30–79%) | In 1 condition |
| OCRLOCRL inositol polyphosphate-5-phosphatase | Often (30–79%) | In 1 condition |
| OSTM1osteoclastogenesis associated transmembrane protein 1 | Often (30–79%) | In 1 condition |
| PRUNE1prune exopolyphosphatase 1 | Often (30–79%) | In 2 conditions |
| RTN2reticulon 2 | Often (30–79%) | In 1 condition |
Show 58 more genes
| Gene | How often it is seen | Conditions |
|---|---|---|
| RUSC2RUN and SH3 domain containing 2 | Often (30–79%) | In 1 condition |
| SLC25A15solute carrier family 25 member 15 | Often (30–79%) | In 2 conditions |
| SLC33A1solute carrier family 33 member 1 | Often (30–79%) | In 1 condition |
| SLC44A1solute carrier family 44 member 1 | Often (30–79%) | In 1 condition |
| UBAP1ubiquitin associated protein 1 | Often (30–79%) | In 1 condition |
| USP8ubiquitin specific peptidase 8 | Often (30–79%) | In 1 condition |
| ATP13A2ATPase cation transporting 13A2 | Sometimes (5–29%) | In 1 condition |
| CRELD1CRELD disulfide isomerase 1 | Sometimes (5–29%) | In 1 condition |
| EBF3EBF transcription factor 3 | Sometimes (5–29%) | In 1 condition |
| ERLIN1ER lipid raft associated 1 | Sometimes (5–29%) | In 2 conditions |
| FKRPfukutin related protein | Sometimes (5–29%) | In 1 condition |
| FUSFUS RNA binding protein | Sometimes (5–29%) | In 1 condition |
| GMPPBGDP-mannose pyrophosphorylase B | Sometimes (5–29%) | In 1 condition |
| GNEglucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase | Sometimes (5–29%) | In 1 condition |
| HTRA2HtrA serine peptidase 2 | Sometimes (5–29%) | In 1 condition |
| HTThuntingtin | Sometimes (5–29%) | In 1 condition |
| INPP4Ainositol polyphosphate-4-phosphatase type I A | Sometimes (5–29%) | In 1 condition |
| KDM1Alysine demethylase 1A | Sometimes (5–29%) | In 1 condition |
| KPNA3karyopherin subunit alpha 3 | Sometimes (5–29%) | In 1 condition |
| LMNB1lamin B1 | Sometimes (5–29%) | In 1 condition |
| NDPnorrin cystine knot growth factor NDP | Sometimes (5–29%) | In 1 condition |
| PCpyruvate carboxylase | Sometimes (5–29%) | In 1 condition |
| PET100PET100 cytochrome c oxidase chaperone | Sometimes (5–29%) | In 1 condition |
| PEX16peroxisomal biogenesis factor 16 | Sometimes (5–29%) | In 1 condition |
| POMGNT1protein O-linked mannose N-acetylglucosaminyltransferase 1 (beta 1,2-) | Sometimes (5–29%) | In 1 condition |
| POMKprotein O-mannose kinase | Sometimes (5–29%) | In 1 condition |
| POMT1protein O-mannosyltransferase 1 | Sometimes (5–29%) | In 1 condition |
| POMT2protein O-mannosyltransferase 2 | Sometimes (5–29%) | In 1 condition |
| PRPS1phosphoribosyl pyrophosphate synthetase 1 | Sometimes (5–29%) | In 1 condition |
| PTS6-pyruvoyltetrahydropterin synthase | Sometimes (5–29%) | In 1 condition |
| RNASEH1ribonuclease H1 | Sometimes (5–29%) | In 1 condition |
| RNU4-2RNA, U4 small nuclear 2 | Sometimes (5–29%) | In 1 condition |
| SETXsenataxin | Sometimes (5–29%) | In 1 condition |
| SIGMAR1sigma receptor chaperone 1 | Sometimes (5–29%) | In 1 condition |
| SLC1A4solute carrier family 1 member 4 | Sometimes (5–29%) | In 1 condition |
| SLC2A3solute carrier family 2 member 3 | Sometimes (5–29%) | In 1 condition |
| SORDsorbitol dehydrogenase | Sometimes (5–29%) | In 1 condition |
| SPG11SPG11 vesicle trafficking associated, spatacsin | Sometimes (5–29%) | In 1 condition |
| SPTLC1serine palmitoyltransferase long chain base subunit 1 | Sometimes (5–29%) | In 1 condition |
| SPTLC2serine palmitoyltransferase long chain base subunit 2 | Sometimes (5–29%) | In 1 condition |
| SYNE1spectrin repeat containing nuclear envelope protein 1 | Sometimes (5–29%) | In 1 condition |
| TARDBPTAR DNA binding protein | Sometimes (5–29%) | In 1 condition |
| TRMT2BtRNA methyltransferase 2B | Sometimes (5–29%) | In 1 condition |
| UBQLN2ubiquilin 2 | Sometimes (5–29%) | In 1 condition |
| UFC1ubiquitin-fold modifier conjugating enzyme 1 | Sometimes (5–29%) | In 1 condition |
| WASHC5WASH complex subunit 5 | Sometimes (5–29%) | In 1 condition |
| SPTBN1spectrin beta, non-erythrocytic 1 | Rarely (1–4%) | In 1 condition |
| BRAT1BRCA1 associated ATM activator 1 | Not recorded | In 1 condition |
| CAV1caveolin 1 | Not recorded | In 1 condition |
| HIKESHIheat shock protein nuclear import factor hikeshi | Not recorded | In 1 condition |
| KCNT1potassium sodium-activated channel subfamily T member 1 | Not recorded | In 1 condition |
| NIPA1NIPA magnesium transporter 1 | Not recorded | In 1 condition |
| PIGPphosphatidylinositol glycan anchor biosynthesis class P | Not recorded | In 1 condition |
| SEPSECSSep (O-phosphoserine) tRNA:Sec (selenocysteine) tRNA synthase | Not recorded | In 1 condition |
| SLC16A2solute carrier family 16 member 2 | Not recorded | In 1 condition |
| SLC6A9solute carrier family 6 member 9 | Not recorded | In 1 condition |
| TRAK1trafficking kinesin protein 1 | Not recorded | In 1 condition |
| ZFYVE26zinc finger FYVE-type containing 26 | Not recorded | In 1 condition |
How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.
Narrower traits
Broader traits
Where this comes from
- The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
- Data release 2026.10.18-8b139e39.
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