Traits

Traits linked to TYROBP

transmembrane immune signaling adaptor TYROBP

The Human Phenotype Ontology links 53 traits to TYROBP, by body system: features seen in people with one of the gene's rare conditions.

Abnormality of the nervous system

Trait	How often it is seen
Dementia	Always
Lateral ventricle dilatation	Always
Behavioral abnormality	Very often (80–99%)
Decrease in size of the outer layer of the brain due to loss of brain cells	Very often (80–99%)
Disinhibition	Very often (80–99%)
Frontal lobe dementia	Very often (80–99%)
Irritability	Very often (80–99%)
Loss of developmental milestones	Very often (80–99%)
Memory impairment	Very often (80–99%)
Personality changes	Very often (80–99%)
Ventriculomegaly	Very often (80–99%)
Abnormal speech pattern	Often (30–79%)
Abnormality of movement	Often (30–79%)
Chorea	Often (30–79%)
Disturbed sensory perception	Often (30–79%)
Epilepsy	Often (30–79%)
Too much cerebrospinal fluid in the brain	Sometimes (5–29%)
Abnormal gait	Not recorded
Abnormal shape of upper motor neuron	Not recorded
Aggressive behavior	Not recorded
Apraxia	Not recorded
Axonal loss	Not recorded
Babinski sign	Not recorded
Caudate atrophy	Not recorded
Degeneration of cerebrum	Not recorded
EEG abnormality	Not recorded
Euphoria	Not recorded
Gliosis	Not recorded
Inappropriate behavior	Not recorded
Jerking	Not recorded
Lack of insight	Not recorded
Leukoencephalopathy	Not recorded
Peripheral demyelination	Not recorded
Primitive reflex	Not recorded
Underdevelopment of part of brain called corpus callosum	Not recorded

Abnormality of the musculoskeletal system

Trait	How often it is seen
Bone cyst	Always
Abnormal shape of end part of bone	Very often (80–99%)
Abnormal skeletal development	Very often (80–99%)
Abnormality of adipose tissue	Very often (80–99%)
Bone pain	Very often (80–99%)
Limitation of joint mobility	Very often (80–99%)
Low solidness and mass of the bones	Very often (80–99%)
Abnormal deposits of calcium in the brain	Often (30–79%)
Involuntary muscle stiffness, contraction, or spasm	Often (30–79%)
Basal ganglia calcification	Not recorded
Spontaneous fracture	Not recorded

Abnormality of limbs

Trait	How often it is seen
Abnormal feet structure	Not recorded
Abnormality of the hand	Not recorded

Abnormality of blood and blood-forming tissues

Trait	How often it is seen
Acute blood cancer	Sometimes (5–29%)

Abnormality of the digestive system

Trait	How often it is seen
Functional abnormality of the gastrointestinal tract	Sometimes (5–29%)

Abnormality of the eye

Trait	How often it is seen
Oculomotor apraxia	Often (30–79%)

Abnormality of the genitourinary system

Trait	How often it is seen
Loss of bladder control	Not recorded

Constitutional symptom

Trait	How often it is seen
Joint pain	Very often (80–99%)

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Where this comes from

The Human Phenotype Ontology, release 2026-09-01: the traits linked to TYROBP and how often each is seen. Find out more at hpo.jax.org.

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