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Trait
Paralysis of all four limbs
Clinical name: Tetraplegia
Paralysis of all four limbs, and trunk of the body below the level of an associated injury to the spinal cord. The etiology of quadriplegia is similar to that of paraplegia except that the lesion is in the cervical spinal cord rather than in the thoracic or lumbar segments of the spinal cord.
Summary
- Also called
- Quadriplegia
- Body system
- Abnormality of the nervous system
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page$trait$nameParalysis of all four limbsHP:0002445
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Get my Genome Test45 condition reports read genes linked to this trait
Dante Labs condition reports look at the genes behind groups of inherited conditions, read from one whole-genome test. Each page says which conditions and genes a report covers, how it is read and what it cannot tell you.
- Familial Glucocorticoid DeficiencyReads 4 of these genesMC2RMRAPNNTTXNRD2About this report →
- FDXR-Related Mitochondrial DisorderReads 1 of these genesFDXRAbout this report →
- Krabbe DiseaseReads 1 of these genesGALCAbout this report →
- P5CS Deficiency (ALDH18A1-Related)Reads 1 of these genesALDH18A1About this report →
Show 41 more reports
- Purine & Pyrimidine Metabolism DisordersReads 2 of these genesPRPS1DPYDAbout this report →
- Malignant Hyperthermia SusceptibilityReads 1 of these genesCACNA1SAbout this report →
- Metachromatic LeukodystrophyReads 1 of these genesARSAAbout this report →
- Rare Hereditary Peripheral NeuropathiesReads 9 of these genesFDXRAIFM1PRPS1ATP5MKGALCMT-ATP6About this report →
- Familial Periodic ParalysisReads 1 of these genesCACNA1SAbout this report →
- Inherited Neurodegenerative DisordersReads 10 of these genesNADK2ALS2ALDH18A1TBCDGALCIFIH1About this report →
- Primary Mitochondrial DiseaseReads 6 of these genesNDUFA8AIFM1ATP5F1AATP5F1DATP5F1EATP5POAbout this report →
- Dystonia, Myotonia, Paroxysmal DyskinesiaReads 3 of these genesBCAP31ATP1A3PNKPAbout this report →
- Familial Hemophagocytic LymphohistiocytosisReads 1 of these genesPRF1About this report →
- Other Inherited LeukodystrophiesReads 4 of these genesNADK2GALCIFIH1ARSAAbout this report →
- Mosaic Variegated Aneuploidy SyndromeReads 1 of these genesBUB1BAbout this report →
- Epilepsy (Full Panel)Reads 6 of these genesPIGAGABRA3ARXATP1A3KCNT1PNKPAbout this report →
- Lissencephaly Spectrum DisordersReads 2 of these genesPAFAH1B1ARXAbout this report →
- Autoimmune Lymphoproliferative Syndrome (ALPS)Reads 1 of these genesKRASAbout this report →
- Congenital Adrenal HyperplasiaReads 1 of these genesSTARAbout this report →
- Leigh SyndromeReads 3 of these genesAIFM1ATP5MKMT-ATP6About this report →
- Aicardi-Goutieres SyndromeReads 1 of these genesIFIH1About this report →
- Type I InterferonopathiesReads 1 of these genesIFIH1About this report →
- Hereditary Optic NeuropathyReads 1 of these genesATP1A3About this report →
- Lysosomal Storage DiseaseReads 2 of these genesGALCARSAAbout this report →
- Cutis LaxaReads 1 of these genesALDH18A1About this report →
- Hereditary Spastic ParaplegiaReads 2 of these genesALDH18A1TFGAbout this report →
- Charcot-Marie-Tooth DiseaseReads 2 of these genesAIFM1PRPS1About this report →
- GPI Anchor Biosynthesis DefectsReads 1 of these genesPIGAAbout this report →
- Autoimmune DiseaseReads 1 of these genesKRASAbout this report →
- Hereditary Sensory and Autonomic Neuropathies (incl. Familial Dysautonomia)Reads 1 of these genesAIFM1About this report →
- Noonan SyndromeReads 1 of these genesKRASAbout this report →
- Syndromic CraniosynostosisReads 1 of these genesFGFR1About this report →
- Other Inborn Errors of ImmunityReads 3 of these genesIFIH1KRASPRF1About this report →
- Hearing Loss and DeafnessReads 2 of these genesAIFM1PRPS1About this report →
- Congenital Disorders of GlycosylationReads 2 of these genesPIGADOLKAbout this report →
- Amyotrophic Lateral Sclerosis (ALS)Reads 1 of these genesALS2About this report →
- Osteogenesis ImperfectaReads 1 of these genesIFIH1About this report →
- Rare Monogenic Autoinflammatory DiseasesReads 1 of these genesIFIH1About this report →
- Autosomal Dominant Cerebellar Ataxias (SCAs and DRPLA)Reads 1 of these genesATP1A3About this report →
- Dilated CardiomyopathyReads 1 of these genesDOLKAbout this report →
- Hypogonadotropic HypogonadismReads 1 of these genesFGFR1About this report →
- Female InfertilityReads 1 of these genesSTARAbout this report →
- Autosomal Recessive Cerebellar Ataxias (incl. CANVAS and AVED)Reads 1 of these genesPNKPAbout this report →
- Hypertrophic CardiomyopathyReads 1 of these genesKRASAbout this report →
- Intellectual DisabilityReads 1 of these genesHIVEP2About this report →
Read the genes linked to Paralysis of all four limbs, and the rest of your genome, with one test.
From $449Free shipping · Results in 6–8 weeks
Get my Genome Test51 genes linked to Paralysis of all four limbs
Changes in these genes cause rare conditions in which Paralysis of all four limbs is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.
| Gene | How often it is seen | Conditions |
|---|---|---|
| ARHGEF15Rho guanine nucleotide exchange factor 15 | Always | In 1 condition |
| COL4A2collagen type IV alpha 2 chain | Always | In 1 condition |
| EEFSECeukaryotic elongation factor, selenocysteine-tRNA specific | Always | In 1 condition |
| FDXRferredoxin reductase | Always | In 1 condition |
| NADK2NAD kinase 2, mitochondrial | Always | In 1 condition |
| NDUFA8NADH:ubiquinone oxidoreductase subunit A8 | Always | In 1 condition |
| NIT1nitrilase 1 | Always | In 1 condition |
| PIGAphosphatidylinositol glycan anchor biosynthesis class A | Always | In 1 condition |
| THAP11THAP domain containing 11 | Always | In 1 condition |
| TRAPPC2Ltrafficking protein particle complex subunit 2L | Always | In 1 condition |
| ALS2alsin Rho guanine nucleotide exchange factor ALS2 | Very often (80–99%) | In 2 conditions |
| BCAP31B cell receptor associated protein 31 | Very often (80–99%) | In 2 conditions |
| CACNA1Scalcium voltage-gated channel subunit alpha1 S | Very often (80–99%) | In 1 condition |
| GABRA3gamma-aminobutyric acid type A receptor subunit alpha3 | Very often (80–99%) | In 1 condition |
| KCNJ18potassium inwardly rectifying channel subfamily J member 18 | Very often (80–99%) | In 1 condition |
| AIFM1apoptosis inducing factor mitochondria associated 1 | Often (30–79%) | In 1 condition |
| ALDH18A1aldehyde dehydrogenase 18 family member A1 | Often (30–79%) | In 2 conditions |
| PAFAH1B1platelet activating factor acetylhydrolase 1b regulatory subunit 1 | Often (30–79%) | In 1 condition |
| PRPS1phosphoribosyl pyrophosphate synthetase 1 | Often (30–79%) | In 2 conditions |
| TBCDtubulin folding cofactor D | Often (30–79%) | In 1 condition |
| ARXaristaless related homeobox | Sometimes (5–29%) | In 2 conditions |
| ATP5F1AATP synthase F1 subunit alpha | Sometimes (5–29%) | In 1 condition |
| ATP5F1DATP synthase F1 subunit delta | Sometimes (5–29%) | In 1 condition |
| ATP5F1EATP synthase F1 subunit epsilon | Sometimes (5–29%) | In 1 condition |
| ATP5MKATP synthase membrane subunit k | Sometimes (5–29%) | In 1 condition |
| ATP5POATP synthase peripheral stalk subunit OSCP | Sometimes (5–29%) | In 1 condition |
| ATPAF2ATP synthase mitochondrial F1 complex assembly factor 2 | Sometimes (5–29%) | In 1 condition |
| BCAS3BCAS3 microtubule associated cell migration factor | Sometimes (5–29%) | In 1 condition |
| BUB1BBUB1 mitotic checkpoint serine/threonine kinase B | Sometimes (5–29%) | In 1 condition |
| CRELD1CRELD disulfide isomerase 1 | Sometimes (5–29%) | In 1 condition |
| DOLKdolichol kinase | Sometimes (5–29%) | In 1 condition |
| FGFR1fibroblast growth factor receptor 1 | Sometimes (5–29%) | In 1 condition |
| GALCgalactosylceramidase | Sometimes (5–29%) | In 1 condition |
| HIVEP2HIVEP zinc finger 2 | Sometimes (5–29%) | In 1 condition |
| IFIH1interferon induced with helicase C domain 1 | Sometimes (5–29%) | In 1 condition |
| KRASKRas proto-oncogene, GTPase | Sometimes (5–29%) | In 1 condition |
| MT-ATP6mitochondrially encoded ATP synthase membrane subunit 6 | Sometimes (5–29%) | In 1 condition |
| MT-ATP8mitochondrially encoded ATP synthase membrane subunit 8 | Sometimes (5–29%) | In 1 condition |
| RANBP2RAN binding protein 2 | Sometimes (5–29%) | In 1 condition |
| MC2Rmelanocortin 2 receptor | Rarely (1–4%) | In 1 condition |
Show 11 more genes
| Gene | How often it is seen | Conditions |
|---|---|---|
| MRAPmelanocortin 2 receptor accessory protein | Rarely (1–4%) | In 1 condition |
| NNTnicotinamide nucleotide transhydrogenase | Rarely (1–4%) | In 1 condition |
| STARsteroidogenic acute regulatory protein | Rarely (1–4%) | In 1 condition |
| TXNRD2thioredoxin reductase 2 | Rarely (1–4%) | In 1 condition |
| ARSAarylsulfatase A | Not recorded | In 1 condition |
| ATP1A3ATPase Na+/K+ transporting subunit alpha 3 | Not recorded | In 1 condition |
| DPYDdihydropyrimidine dehydrogenase | Not recorded | In 1 condition |
| KCNT1potassium sodium-activated channel subfamily T member 1 | Not recorded | In 1 condition |
| PNKPpolynucleotide kinase 3'-phosphatase | Not recorded | In 1 condition |
| PRF1perforin 1 | Not recorded | In 1 condition |
| TFGtrafficking from ER to golgi regulator | Not recorded | In 1 condition |
How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.
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Broader traits
Where this comes from
- The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
- Data release 2026.10.19-9814e911.
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