Trait
Increased circulating potassium concentration
Clinical name: Hyperkalemia
The concentration of potassium(1+) in the blood circulation is above the upper limit of normal.
Summary
- Also called
- Elevated potassium(1+) concentration, Elevated potassium(1+) level, Elevated potassium(1+) level in blood, Increased potassium(1+) concentration, Increased potassium(1+) level, Increased potassium(1+) level in blood
- Body system
- Laboratory abnormality
Reference genomeGRCh38hg38
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Get my Genome Test42 genes linked to Increased circulating potassium concentration
Changes in these genes cause rare conditions in which Increased circulating potassium concentration is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.
| Gene | How often it is seen | Conditions |
|---|---|---|
| CYP11B2cytochrome P450 family 11 subfamily B member 2 | Always | In 3 conditions |
| NR3C2nuclear receptor subfamily 3 group C member 2 | Always | In 1 condition |
| OAS22'-5'-oligoadenylate synthetase 2 | Always | In 1 condition |
| POLG2DNA polymerase gamma 2, accessory subunit | Always | In 1 condition |
| SCNN1Asodium channel epithelial 1 subunit alpha | Always | In 2 conditions |
| SCNN1Gsodium channel epithelial 1 subunit gamma | Always | In 2 conditions |
| SLC2A1solute carrier family 2 member 1 | Always | In 1 condition |
| SLC4A2solute carrier family 4 member 2 | Always | In 1 condition |
| WNK1WNK lysine deficient protein kinase 1 | Always | In 1 condition |
| ABCB6ATP binding cassette subfamily B member 6 (LAN blood group) | Very often (80–99%) | In 2 conditions |
| CYP11A1cytochrome P450 family 11 subfamily A member 1 | Very often (80–99%) | In 2 conditions |
| SCNN1Bsodium channel epithelial 1 subunit beta | Very often (80–99%) | In 2 conditions |
| HSD3B2hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2 | Often (30–79%) | In 2 conditions |
| MC2Rmelanocortin 2 receptor | Often (30–79%) | In 1 condition |
| MRAPmelanocortin 2 receptor accessory protein | Often (30–79%) | In 1 condition |
| NNTnicotinamide nucleotide transhydrogenase | Often (30–79%) | In 1 condition |
| NR0B1nuclear receptor subfamily 0 group B member 1 | Often (30–79%) | In 1 condition |
| PORcytochrome p450 oxidoreductase | Often (30–79%) | In 1 condition |
| SCN4Asodium voltage-gated channel alpha subunit 4 | Often (30–79%) | In 2 conditions |
| SEC61A1SEC61 translocon subunit alpha 1 | Often (30–79%) | In 1 condition |
| SLC30A9solute carrier family 30 member 9 | Often (30–79%) | In 1 condition |
| STARsteroidogenic acute regulatory protein | Often (30–79%) | In 1 condition |
| TXNRD2thioredoxin reductase 2 | Often (30–79%) | In 1 condition |
| ALDOAaldolase, fructose-bisphosphate A | Sometimes (5–29%) | In 1 condition |
| CACNA1Scalcium voltage-gated channel subunit alpha1 S | Sometimes (5–29%) | In 2 conditions |
| LPIN1lipin 1 | Sometimes (5–29%) | In 2 conditions |
| MT-CO1mitochondrially encoded cytochrome c oxidase I | Sometimes (5–29%) | In 1 condition |
| MT-CO3mitochondrially encoded cytochrome c oxidase III | Sometimes (5–29%) | In 1 condition |
| OBSCNobscurin, cytoskeletal calmodulin and titin-interacting RhoGEF | Sometimes (5–29%) | In 1 condition |
| PAX2paired box 2 | Sometimes (5–29%) | In 1 condition |
| PBX1PBX homeobox 1 | Sometimes (5–29%) | In 1 condition |
| RYR1ryanodine receptor 1 | Sometimes (5–29%) | In 3 conditions |
| GABRA3gamma-aminobutyric acid type A receptor subunit alpha3 | Rarely (1–4%) | In 1 condition |
| KCNJ18potassium inwardly rectifying channel subfamily J member 18 | Rarely (1–4%) | In 1 condition |
| CA12carbonic anhydrase 12 | Not recorded | In 1 condition |
| CUL3cullin 3 | Not recorded | In 1 condition |
| INVSinversin | Not recorded | In 1 condition |
| KLHL3kelch like family member 3 | Not recorded | In 1 condition |
| NFKB2nuclear factor kappa B subunit 2 | Not recorded | In 1 condition |
| SAMD9sterile alpha motif domain containing 9 | Not recorded | In 1 condition |
Show 2 more genes
How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.
Broader traits
Where this comes from
- The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
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