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Gene

PADI6

peptidyl arginine deiminase 6

Summary

Cytogenetic location
1p36.13
Coordinates
Chromosome 1: 17,372,196–17,401,699 (GRCh38)
Exons
16 exons across 29.5 kb
Protein
694 amino acids
MANE Select transcript
ENST00000619609.1NM_207421.4
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated report relevant to this gene

  • Female Infertility

    • inherited oocyte maturation defect
      • 3 GenCC submitters rate it definitive or strong

How PADI6 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 1, with a bracket where PADI6 sits. PADI6 and 12 genes near it on chromosome 1, from 16,886,948 to 17,886,947.Chromosome 11p36.13p36.33p36.32p36.31p36.23p36.22p36.21p36.13p36.12p36.11p35.3p35.2p35.1p34.3p34.2p34.1p33p32.3p32.2p32.1p31.3p31.2p31.1p22.3p22.2p22.1p21.3p21.2p21.1p13.3p13.2p13.1p12p11.2p11.1q11q12q21.1q21.2q21.3q22q23.1q23.2q23.3q24.1q24.2q24.3q25.1q25.2q25.3q31.1q31.2q31.3q32.1q32.2q32.3q41q42.11q42.12q42.13q42.2q42.3q43q4417 Mb17.2 Mb17.4 Mb17.6 Mb17.8 MbCROCC: 16,740,273–16,972,964, forward strandCROCCMFAP2: 16,972,933–16,981,616, reverse strandMFAP2ATP13A2: 16,985,958–17,011,986, reverse strandATP13A2: 17,005,068–17,011,757, reverse strandSDHB: 17,018,664–17,054,210, reverse strandSDHBPADI2: 17,066,761–17,119,459, reverse strandPADI2PADI1: 17,205,120–17,246,007, forward strandPADI1PADI3: 17,249,093–17,284,233, forward strandPADI3PADI4: 17,308,195–17,364,004, forward strandPADI4PADI6: 17,372,196–17,401,699, forward strandPADI6RCC2: 17,406,755–17,439,992, reverse strandRCC2ARHGEF10L: 17,539,368–17,697,876, forward strandARHGEF10LACTL8: 17,755,310–17,827,063, forward strandACTL8Diagram of PADI6: 16 exons on the forward strand of chromosome 1Exon 1: 2 known disease-causing sitesExon 3: 1 known disease-causing siteExon 6: 3 known disease-causing sitesExon 7: 2 known disease-causing sitesExon 9: 2 known disease-causing sitesExon 13: 1 known disease-causing siteExon 14: 1 known disease-causing siteExon 16: 3 known disease-causing sitesExon 1: 17,372,196–17,372,361, 166 basesExon 2: 17,373,056–17,373,233, 178 basesExon 3: 17,375,427–17,375,499, 73 basesExon 4: 17,379,920–17,379,987, 68 basesExon 5: 17,381,047–17,381,164, 118 basesExon 6: 17,381,967–17,382,092, 126 basesExon 7: 17,388,381–17,388,559, 179 basesExon 8: 17,388,777–17,388,880, 104 basesExon 9: 17,392,114–17,392,225, 112 basesExon 10: 17,393,975–17,394,082, 108 basesExon 11: 17,394,300–17,394,454, 155 basesExon 12: 17,394,951–17,395,107, 157 basesExon 13: 17,395,540–17,395,663, 124 basesExon 14: 17,397,071–17,397,141, 71 basesExon 15: 17,398,686–17,398,847, 162 basesExon 16: 17,401,205–17,401,699, 495 bases12468101214165′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 2.4 kb of the gene's 29.5 kb; 2,085 of those bases code for the protein.

How a genome test reads PADI6

16

positions in PADI6 where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 29.5 kb of PADI6, introns included, not only the 2.4 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). PADI6 gene: peptidyl arginine deiminase 6. Retrieved 17 October 2026, from https://dantelabs.com/genes/padi6

Vancouver

Dante Labs. PADI6 gene: peptidyl arginine deiminase 6 [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/padi6

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