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Gene

KPNA7

karyopherin subunit alpha 7

Summary

Cytogenetic location
7q22.1
Coordinates
Chromosome 7: 99,173,572–99,208,115 (GRCh38)
Exons
11 exons across 34.5 kb
Protein
516 amino acids
Also known as
IPOA8
MANE Select transcript
ENST00000327442.7NM_001145715.3
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated report relevant to this gene

  • Female Infertility

    • inherited oocyte maturation defect
      • 1 GenCC submitter rates it definitive or strong

How KPNA7 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Stretches short reads find hard
Chromosome 7, with a bracket where KPNA7 sits. KPNA7 and 23 genes near it on chromosome 7, from 98,690,844 to 99,690,843.Chromosome 77q22.1p22.3p22.2p22.1p21.3p21.2p21.1p15.3p15.2p15.1p14.3p14.2p14.1p13p12.3p12.2p12.1p11.2p11.1q11.1q11.21q11.22q11.23q21.11q21.12q21.13q21.2q21.3q22.1q22.2q22.3q31.1q31.2q31.31q31.32q31.33q32.1q32.2q32.3q33q34q35q36.1q36.2q36.398.8 Mb99 Mb99.2 Mb99.4 Mb99.6 MbTMEM130: 98,846,478–98,870,771, reverse strandTMEM130TRRAP: 98,877,933–99,050,831, forward strandTRRAPSMURF1: 99,027,435–99,144,171, reverse strandSMURF1KPNA7: 99,173,572–99,208,115, reverse strandKPNA7MYH16: 99,272,839–99,311,132, forward strandMYH16ARPC1A: 99,325,879–99,366,527, forward strandARPC1A: 99,325,879–99,394,653, forward strandARPC1B: 99,374,226–99,398,124, forward strandARPC1BPDAP1: 99,392,048–99,408,831, reverse strandPDAP1BUD31: 99,408,610–99,419,618, forward strandBUD31PTCD1: 99,415,192–99,466,201, reverse strandPTCD1ATP5MF-PTCD1: 99,419,749–99,466,197, reverse strandCPSF4: 99,438,908–99,458,910, forward strandATP5MF: 99,448,475–99,466,201, reverse strandATP5MFZNF789: 99,472,794–99,503,650, forward strandZNF394: 99,473,877–99,504,918, reverse strandZKSCAN5: 99,504,634–99,535,360, forward strandZKSCAN5ZBED8L: 99,546,204–99,559,392, reverse strandZBED8LZNF655: 99,558,389–99,578,948, forward strandZNF655: 99,558,695–99,607,810, forward strandTMEM225B: 99,597,868–99,611,045, forward strandTMEM225BZSCAN25: 99,616,623–99,738,531, forward strandZSCAN25CYP3A5: 99,647,442–99,680,043, reverse strandCYP3A5CYP3A7-CYP3A51P: 99,684,957–99,735,102, reverse strandDiagram of KPNA7: 11 exons on the reverse strand of chromosome 7Exon 11: 99,173,572–99,173,794, 223 basesExon 10: 99,177,920–99,178,066, 147 basesExon 9: 99,181,883–99,182,065, 183 basesExon 8: 99,184,929–99,185,162, 234 basesExon 7: 99,188,300–99,188,563, 264 basesExon 6: 99,193,019–99,193,101, 83 basesExon 5: 99,195,070–99,195,338, 269 basesExon 4: 99,196,084–99,196,166, 83 basesExon 3: 99,203,106–99,203,240, 135 basesExon 2: 99,207,401–99,207,489, 89 basesExon 1: 99,208,028–99,208,115, 88 bases11109876543215′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 1.8 kb of the gene's 34.5 kb; 1,551 of those bases code for the protein.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). KPNA7 gene: karyopherin subunit alpha 7. Retrieved 16 October 2026, from https://dantelabs.com/genes/kpna7

Vancouver

Dante Labs. KPNA7 gene: karyopherin subunit alpha 7 [Internet]. [cited 16 October 2026]. Available from: https://dantelabs.com/genes/kpna7

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