Trait

Cleft tongue

Clinical name: Bifid tongue

Tongue with a median apical indentation or fork.

HPO HP:0010297

Also called: Forked tongue, Snake tongue, Split tongue, Bifurcated tongue, Bilobed tongue
Body system: Abnormality of head or neck

This page as data

Add .json to the page's address, or ask for application/json, to read it as JSON.

library(jsonlite)

url <- "https://dantelabs.com/traits/bifid-tongue.json"
page <- fromJSON(url)
page$trait$name

Open the JSON

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25 genes linked to Cleft tongue

Changes in these genes cause rare conditions in which Cleft tongue is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.

Gene	How often it is seen	Conditions
DVL3dishevelled segment polarity protein 3	Always	In 2 conditions
ALX3ALX homeobox 3	Often (30–79%)	In 1 condition
C2CD3C2 domain containing 3 centriole elongation regulator	Often (30–79%)	In 2 conditions
DDX59DEAD-box helicase 59	Often (30–79%)	In 2 conditions
DVL1dishevelled segment polarity protein 1	Often (30–79%)	In 3 conditions
FRAS1Fraser extracellular matrix complex subunit 1	Often (30–79%)	In 1 condition
FREM2FRAS1 related extracellular matrix 2	Often (30–79%)	In 1 condition
FZD2frizzled class receptor 2	Often (30–79%)	In 1 condition
GRIP1glutamate receptor interacting protein 1	Often (30–79%)	In 1 condition
HNRNPKheterogeneous nuclear ribonucleoprotein K	Often (30–79%)	In 3 conditions
MCTP2multiple C2 and transmembrane domain containing 2	Often (30–79%)	In 1 condition
NEK1NIMA related kinase 1	Often (30–79%)	In 2 conditions
NXNnucleoredoxin	Often (30–79%)	In 1 condition
RIPK4receptor interacting serine/threonine kinase 4	Often (30–79%)	In 1 condition
ROR2ROR family WNT receptor 2	Often (30–79%)	In 2 conditions
WNT5AWnt family member 5A	Often (30–79%)	In 2 conditions
DHCR77-dehydrocholesterol reductase	Sometimes (5–29%)	In 1 condition
DYNC2H1dynein cytoplasmic 2 heavy chain 1	Sometimes (5–29%)	In 2 conditions
DYNC2I1dynein 2 intermediate chain 1	Sometimes (5–29%)	In 1 condition
DYNC2I2dynein 2 intermediate chain 2	Sometimes (5–29%)	In 1 condition
IFT80intraflagellar transport 80	Sometimes (5–29%)	In 1 condition
IPO8importin 8	Sometimes (5–29%)	In 1 condition
OFD1OFD1 centriole and centriolar satellite protein	Sometimes (5–29%)	In 1 condition
WDR35WD repeat domain 35	Sometimes (5–29%)	In 1 condition
CEP120centrosomal protein 120	Not recorded	In 1 condition

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Broader traits

Abnormal tongue morphology

Where this comes from

The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
Data release 2026.10.16-c6eea6bf.

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