Trait
Loss of articulate speech
Clinical name: Anarthria
A defect in the motor ability that enables speech.
Summary
- Body system
- Abnormality of the nervous system
Reference genomeGRCh38hg38
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Get my Genome Test26 genes linked to Loss of articulate speech
Changes in these genes cause rare conditions in which Loss of articulate speech is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.
| Gene | How often it is seen | Conditions |
|---|---|---|
| ALS2alsin Rho guanine nucleotide exchange factor ALS2 | Always | In 4 conditions |
| DSTdystonin | Always | In 1 condition |
| RRP12ribosomal RNA processing 12 homolog | Always | In 1 condition |
| ATP13A2ATPase cation transporting 13A2 | Often (30–79%) | In 3 conditions |
| FA2Hfatty acid 2-hydroxylase | Often (30–79%) | In 1 condition |
| UBA1ubiquitin like modifier activating enzyme 1 | Often (30–79%) | In 1 condition |
| ALDH18A1aldehyde dehydrogenase 18 family member A1 | Sometimes (5–29%) | In 1 condition |
| DNAJC6DnaJ heat shock protein family (Hsp40) member C6 | Sometimes (5–29%) | In 1 condition |
| ERLIN1ER lipid raft associated 1 | Sometimes (5–29%) | In 1 condition |
| FUSFUS RNA binding protein | Sometimes (5–29%) | In 1 condition |
| GNEglucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase | Sometimes (5–29%) | In 1 condition |
| KMT2Blysine methyltransferase 2B | Sometimes (5–29%) | In 1 condition |
| NAA60N-alpha-acetyltransferase 60, NatF catalytic subunit | Sometimes (5–29%) | In 1 condition |
| PODXLpodocalyxin like | Sometimes (5–29%) | In 1 condition |
| SIGMAR1sigma receptor chaperone 1 | Sometimes (5–29%) | In 1 condition |
| SORDsorbitol dehydrogenase | Sometimes (5–29%) | In 1 condition |
| SPG11SPG11 vesicle trafficking associated, spatacsin | Sometimes (5–29%) | In 1 condition |
| SPTLC1serine palmitoyltransferase long chain base subunit 1 | Sometimes (5–29%) | In 1 condition |
| SPTLC2serine palmitoyltransferase long chain base subunit 2 | Sometimes (5–29%) | In 1 condition |
| SYNE1spectrin repeat containing nuclear envelope protein 1 | Sometimes (5–29%) | In 1 condition |
| SYNJ1synaptojanin 1 | Sometimes (5–29%) | In 1 condition |
| TARDBPTAR DNA binding protein | Sometimes (5–29%) | In 1 condition |
| TBCEtubulin folding cofactor E | Sometimes (5–29%) | In 1 condition |
| TRMT2BtRNA methyltransferase 2B | Sometimes (5–29%) | In 1 condition |
| UBQLN2ubiquilin 2 | Sometimes (5–29%) | In 1 condition |
| FTLferritin light chain | Not recorded | In 1 condition |
How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.
Broader traits
Where this comes from
- The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
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