Trait

Pill-rolling tremor

A type of resting tremor characterized by simultaneous rubbing movements of thumb and index fingers against each other.

HPO HP:0025387

Also called: Pill rolling
Body system: Abnormality of the nervous system

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8 genes linked to Pill-rolling tremor

Changes in these genes cause rare conditions in which Pill-rolling tremor is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.

Gene	How often it is seen	Conditions
DNAJC6DnaJ heat shock protein family (Hsp40) member C6	Always	In 1 condition
PRKNparkin RBR E3 ubiquitin protein ligase	Always	In 1 condition
PLA2G6phospholipase A2 group VI	Often (30–79%)	In 1 condition
CDKL5cyclin dependent kinase like 5	Sometimes (5–29%)	In 1 condition
GABBR2gamma-aminobutyric acid type B receptor subunit 2	Sometimes (5–29%)	In 1 condition
MECP2methyl-CpG binding protein 2	Sometimes (5–29%)	In 1 condition
NTNG1netrin G1	Sometimes (5–29%)	In 1 condition
SMC1Astructural maintenance of chromosomes 1A	Sometimes (5–29%)	In 1 condition

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Broader traits

Resting tremor

Where this comes from

The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
Data release 2026.10.16-c6eea6bf.

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