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Gene

SRRM2

serine/arginine repetitive matrix 2

Summary

Cytogenetic location
16p13.3
Coordinates
Chromosome 16: 2,752,638–2,771,412 (GRCh38)
Exons
15 exons across 18.8 kb
Protein
2,752 amino acids
Also known as
SRm300, SRL300, KIAA0324, Cwc21
MANE Select transcript
ENST00000301740.13NM_016333.4
Locus type
gene with protein product

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated report relevant to this gene

    How SRRM2 is laid out

    • Coding sequence
    • Untranslated region
    • Intron
    • Direction of transcription
    • Known disease-causing sites
    Chromosome 16, with a bracket where SRRM2 sits. SRRM2 and 41 genes near it on chromosome 16, from 2,262,025 to 3,262,024.Chromosome 1616p13.3p13.3p13.2p13.13p13.12p13.11p12.3p12.2p12.1p11.2p11.1q11.1q11.2q12.1q12.2q13q21q22.1q22.2q22.3q23.1q23.2q23.3q24.1q24.2q24.32.4 Mb2.6 Mb2.8 Mb3 Mb3.2 MbRNPS1: 2,253,116–2,268,413, reverse strandRNPS1ABCA3: 2,275,878–2,340,788, reverse strandABCA3CCNF: 2,429,394–2,458,913, forward strandCCNFTEDC2: 2,460,085–2,464,963, forward strandTEDC2NTN3: 2,471,286–2,474,145, forward strandNTN3TBC1D24: 2,475,051–2,509,671, forward strand: 2,496,032–2,520,218, forward strandATP6V0C: 2,513,713–2,520,218, forward strand: 2,513,965–2,527,955, forward strandAMDHD2: 2,520,340–2,531,422, forward strandAMDHD2CEMP1: 2,530,035–2,531,417, reverse strandCEMP1PDPK1: 2,537,969–2,603,190, forward strandPDPK1KCTD5: 2,682,516–2,709,030, forward strandKCTD5PRSS27: 2,712,419–2,721,270, reverse strandPRSS27SRRM2: 2,752,638–2,771,412, forward strandSRRM2ELOB: 2,771,413–2,777,320, reverse strandELOBPRSS33: 2,783,926–2,787,948, reverse strandPRSS33PRSS41: 2,798,470–2,805,304, forward strandPRSS41PRSS21: 2,817,130–2,826,304, forward strandPRSS21ZG16B: 2,830,162–2,839,585, forward strandZG16BPRSS22: 2,852,728–2,858,677, reverse strandPRSS22FLYWCH2: 2,882,868–2,903,099, forward strandFLYWCH2FLYWCH1: 2,911,599–2,951,208, forward strandFLYWCH1KREMEN2: 2,963,625–2,968,380, forward strandKREMEN2PKMYT1: 2,968,024–2,980,813, reverse strandPKMYT1PAQR4: 2,969,242–2,973,484, forward strandPAQR4GREP1: 2,988,256–3,002,295, forward strandGREP1: 3,004,132–3,004,859, forward strandCLDN9: 3,012,923–3,014,505, forward strandCLDN6: 3,014,705–3,020,071, reverse strandTNFRSF12A: 3,018,445–3,022,385, forward strandTHOC6: 3,022,541–3,027,755, forward strandHCFC1R1: 3,022,625–3,024,312, reverse strandBICDL2: 3,027,682–3,036,993, reverse strandMMP25: 3,046,062–3,060,729, forward strandMMP25IL32: 3,064,301–3,082,192, forward strandIL32ZSCAN10: 3,088,888–3,099,370, reverse strandZSCAN10ZNF205: 3,112,550–3,120,527, forward strandZNF205ZNF213: 3,129,777–3,142,804, forward strandZNF213OR1F1: 3,188,204–3,224,779, forward strandOR1F1ZNF200: 3,222,324–3,236,221, reverse strandZNF200MEFV: 3,240,392–3,256,954, reverse strandMEFVDiagram of SRRM2: 15 exons on the forward strand of chromosome 16Exon 2: 5 known disease-causing sitesExon 6: 1 known disease-causing siteExon 7: 1 known disease-causing siteExon 8: 1 known disease-causing siteExon 11: 36 known disease-causing sitesExon 12: 1 known disease-causing siteExon 1: 2,752,638–2,752,846, 209 basesExon 2: 2,756,334–2,756,606, 273 basesExon 3: 2,757,472–2,757,579, 108 basesExon 4: 2,757,781–2,757,945, 165 basesExon 5: 2,758,470–2,758,547, 78 basesExon 6: 2,758,985–2,759,047, 63 basesExon 7: 2,759,140–2,759,172, 33 basesExon 8: 2,759,352–2,759,402, 51 basesExon 9: 2,759,569–2,759,661, 93 basesExon 10: 2,760,301–2,760,499, 199 basesExon 11: 2,761,561–2,768,261, 6,701 basesExon 12: 2,768,997–2,769,284, 288 basesExon 13: 2,770,352–2,770,465, 114 basesExon 14: 2,770,604–2,770,717, 114 basesExon 15: 2,770,858–2,771,412, 555 bases12468101214155′3′

    Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

    Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

    Nearby genes from Ensembl release 116, on GRCh38.

    Exons make up 9 kb of the gene's 18.8 kb; 8,259 of those bases code for the protein.

    How a genome test reads SRRM2

    46

    positions in SRRM2 where ClinVar classes a change as pathogenic or likely pathogenic

    None of them falls in a region short reads find hard.

    A whole genome covers all 18.8 kb of SRRM2, introns included, not only the 9 kb of exons.

    Where this comes from

    • HGNC: the gene's symbol, name, other symbols and location.
    • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
    • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
    • The ACMG secondary findings list, SF v3.2.
    • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
    • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
    • Data release 2026.10.16-c6eea6bf.

    Cite this page

    APA

    Dante Labs. (n.d.). SRRM2 gene: serine/arginine repetitive matrix 2. Retrieved 16 October 2026, from https://dantelabs.com/genes/srrm2

    Vancouver

    Dante Labs. SRRM2 gene: serine/arginine repetitive matrix 2 [Internet]. [cited 16 October 2026]. Available from: https://dantelabs.com/genes/srrm2

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