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Traits

Traits linked to F8

coagulation factor VIII

The Human Phenotype Ontology links 60 traits to F8, by body system: features seen in people with one of the gene's rare conditions.

Abnormality of blood and blood-forming tissues

TraitKui sageli seda täheldatakse
Blood clot in cerebral veinAlati
Blood clot in portal veinAlati
Increased factor VIII activityAlati
Left ventricular thrombusAlati
Recurrent deep vein blood clotAlati
Bleeding tendencyVäga sageli (80–99%)
Bruising susceptibilityVäga sageli (80–99%)
Prolonged partial thromboplastin timeVäga sageli (80–99%)
Reduced factor VIII activityVäga sageli (80–99%)
Abnormally heavy bleeding during menstruationSageli (30–79%)
Bleeding below the skinSageli (30–79%)
Bleeding gumsSageli (30–79%)
Bleeding post-deliverySageli (30–79%)
Bleeding with minor or no traumaSageli (30–79%)
Bleeding within a jointSageli (30–79%)
Blood clot in a deep veinSageli (30–79%)
Bloody noseSageli (30–79%)
Excessive bleeding after minor traumaSageli (30–79%)
Oral cavity bleedingSageli (30–79%)
Prolonged bleeding after dental extractionSageli (30–79%)
Prolonged bleeding after surgerySageli (30–79%)
Prolonged bleeding following procedureSageli (30–79%)
Black fecesMõnikord (5–29%)
Bleeding within the skullMõnikord (5–29%)
CephalohematomaMõnikord (5–29%)
Epidural hemorrhageMõnikord (5–29%)
Gastrointestinal bleedingMõnikord (5–29%)
Low number of red blood cells or hemoglobinMõnikord (5–29%)
Prolonged bleeding following circumcisionMõnikord (5–29%)
Prolonged prothrombin timeMõnikord (5–29%)
Reduced von Willebrand factor activityMõnikord (5–29%)
Subdural hemorrhageMõnikord (5–29%)
Vomiting bloodMõnikord (5–29%)
Blood spotsHarva (1–4%)
Intraventricular hemorrhageHarva (1–4%)
PetechiaeHarva (1–4%)
Spontaneous hematomasHarva (1–4%)
Muscle hemorrhagePole registreeritud

Abnormality of the musculoskeletal system

TraitKui sageli seda täheldatakse
Intramuscular hematomaSageli (30–79%)
Cartilage destructionMõnikord (5–29%)
Disease of the jointsMõnikord (5–29%)
Limb contracturesMõnikord (5–29%)
Limitation of joint mobilityMõnikord (5–29%)
Progressive joint destructionMõnikord (5–29%)
SynovitisMõnikord (5–29%)
Degenerative joint diseasePole registreeritud

Abnormality of the cardiovascular system

TraitKui sageli seda täheldatakse
Increased spleen sizeAlati
Portal hypertensionAlati
Splenic infarctionAlati
StrokeAlati
Blood clot in artery of lungSageli (30–79%)

Laboratory abnormality

TraitKui sageli seda täheldatakse
Joint swellingSageli (30–79%)
Blood in urineMõnikord (5–29%)
Bloody urineMõnikord (5–29%)

Abnormality of the nervous system

TraitKui sageli seda täheldatakse
EpilepsyAlati
HeadacheMõnikord (5–29%)

Abnormality of limbs

TraitKui sageli seda täheldatakse
Hip contractureHarva (1–4%)

Abnormality of the digestive system

TraitKui sageli seda täheldatakse
Liver failureAlati

Abnormality of the integument

TraitKui sageli seda täheldatakse
Poor wound healingSageli (30–79%)

Constitutional symptom

TraitKui sageli seda täheldatakse
Joint painSageli (30–79%)

Kui sageli see esineb geenist tulenevate seisunditega inimeste seas, kõige sagedamini nende kõigi seas, nagu on märgitud Inimese fenotüübi ontoloogias. Need lehed kirjeldavad tunnuseid ja nende taga olevaid uuringuid; need ei ole diagnoos ning sümptomite kohta tuleks küsida arstilt või geneetilt nõustajalt.

Allikas

  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to F8 and how often each is seen. Find out more at hpo.jax.org.

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