Traits

Traits linked to F8

coagulation factor VIII

The Human Phenotype Ontology links 60 traits to F8, by body system: features seen in people with one of the gene's rare conditions.

Abnormality of blood and blood-forming tissues

Trait	Kaip dažnai pasireiškia
Blood clot in cerebral vein	Visada
Blood clot in portal vein	Visada
Increased factor VIII activity	Visada
Left ventricular thrombus	Visada
Recurrent deep vein blood clot	Visada
Bleeding tendency	Labai dažnai (80–99%)
Bruising susceptibility	Labai dažnai (80–99%)
Prolonged partial thromboplastin time	Labai dažnai (80–99%)
Reduced factor VIII activity	Labai dažnai (80–99%)
Abnormally heavy bleeding during menstruation	Dažnai (30–79%)
Bleeding below the skin	Dažnai (30–79%)
Bleeding gums	Dažnai (30–79%)
Bleeding post-delivery	Dažnai (30–79%)
Bleeding with minor or no trauma	Dažnai (30–79%)
Bleeding within a joint	Dažnai (30–79%)
Blood clot in a deep vein	Dažnai (30–79%)
Bloody nose	Dažnai (30–79%)
Excessive bleeding after minor trauma	Dažnai (30–79%)
Oral cavity bleeding	Dažnai (30–79%)
Prolonged bleeding after dental extraction	Dažnai (30–79%)
Prolonged bleeding after surgery	Dažnai (30–79%)
Prolonged bleeding following procedure	Dažnai (30–79%)
Black feces	Kartais (5–29%)
Bleeding within the skull	Kartais (5–29%)
Cephalohematoma	Kartais (5–29%)
Epidural hemorrhage	Kartais (5–29%)
Gastrointestinal bleeding	Kartais (5–29%)
Low number of red blood cells or hemoglobin	Kartais (5–29%)
Prolonged bleeding following circumcision	Kartais (5–29%)
Prolonged prothrombin time	Kartais (5–29%)
Reduced von Willebrand factor activity	Kartais (5–29%)
Subdural hemorrhage	Kartais (5–29%)
Vomiting blood	Kartais (5–29%)
Blood spots	Retai (1–4 %)
Intraventricular hemorrhage	Retai (1–4 %)
Petechiae	Retai (1–4 %)
Spontaneous hematomas	Retai (1–4 %)
Muscle hemorrhage	Neužfiksuota

Abnormality of the musculoskeletal system

Trait	Kaip dažnai pasireiškia
Intramuscular hematoma	Dažnai (30–79%)
Cartilage destruction	Kartais (5–29%)
Disease of the joints	Kartais (5–29%)
Limb contractures	Kartais (5–29%)
Limitation of joint mobility	Kartais (5–29%)
Progressive joint destruction	Kartais (5–29%)
Synovitis	Kartais (5–29%)
Degenerative joint disease	Neužfiksuota

Abnormality of the cardiovascular system

Trait	Kaip dažnai pasireiškia
Increased spleen size	Visada
Portal hypertension	Visada
Splenic infarction	Visada
Stroke	Visada
Blood clot in artery of lung	Dažnai (30–79%)

Laboratory abnormality

Trait	Kaip dažnai pasireiškia
Joint swelling	Dažnai (30–79%)
Blood in urine	Kartais (5–29%)
Bloody urine	Kartais (5–29%)

Abnormality of the nervous system

Trait	Kaip dažnai pasireiškia
Epilepsy	Visada
Headache	Kartais (5–29%)

Abnormality of limbs

Trait	Kaip dažnai pasireiškia
Hip contracture	Retai (1–4 %)

Abnormality of the digestive system

Trait	Kaip dažnai pasireiškia
Liver failure	Visada

Abnormality of the integument

Trait	Kaip dažnai pasireiškia
Poor wound healing	Dažnai (30–79%)

Constitutional symptom

Trait	Kaip dažnai pasireiškia
Joint pain	Dažnai (30–79%)

Kaip dažnai šis požymis pasitaiko žmonėms, turintiems vieną iš geno sukeliamų ligų, ir kuris dažnis tarp jų didžiausias, pagal Žmogaus fenotipo ontologijos duomenis. Šiuose puslapiuose aprašomi požymiai ir juos grindžiantys tyrimai; tai nėra diagnozė, o su simptomais kreipkitės į gydytoją ar genetikos konsultantą.

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The Human Phenotype Ontology, release 2026-09-01: the traits linked to F8 and how often each is seen. Find out more at hpo.jax.org.

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