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Gene

HCN4

hyperpolarization activated cyclic nucleotide gated potassium channel 4

Summary

Cytogenetic location
15q24.1
Coordinates
Chromosome 15: 73,319,859–73,368,958 (GRCh38)
Exons
8 exons across 49.1 kb
Protein
1,203 amino acids
MANE Select transcript
ENST00000261917.4NM_005477.3
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated report relevant to this gene

  • Progressive Cardiac Conduction Disease & Sick Sinus Syndrome

    • Familial Sick Sinus Syndrome

      An inherited dysfunction of the heart's natural pacemaker, caused by changes in genes such as HCN4, SCN5A and MYH6, that causes slow or irregular heart rhythms.

      • ClinGen rates the link definitive
      • 4 GenCC submitters rate it definitive or strong
      What knowing changes

      Knowing about it supports monitoring for slow heart rhythms and a pacemaker if symptoms develop.

How HCN4 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
Chromosome 15, with a bracket where HCN4 sits. HCN4 and 5 genes near it on chromosome 15, from 72,844,409 to 73,844,408.Chromosome 1515q24.1p13p12p11.2p11.1q11.1q11.2q12q13.1q13.2q13.3q14q15.1q15.2q15.3q21.1q21.2q21.3q22.1q22.2q22.31q22.32q22.33q23q24.1q24.2q24.3q25.1q25.2q25.3q26.1q26.2q26.373 Mb73.2 Mb73.4 Mb73.6 Mb73.8 MbNEO1: 73,051,645–73,305,205, forward strandNEO1HCN4: 73,319,859–73,368,958, reverse strandHCN4REC114: 73,443,147–73,560,020, forward strandREC114NPTN: 73,546,512–73,634,134, reverse strandNPTNCD276: 73,683,966–73,714,519, forward strandCD276INSYN1: 73,735,440–73,753,357, reverse strandINSYN1Diagram of HCN4: 8 exons on the reverse strand of chromosome 15Exon 8: 2 known disease-causing sitesExon 4: 7 known disease-causing sitesExon 2: 4 known disease-causing sitesExon 8: 73,319,859–73,323,949, 4,091 basesExon 7: 73,324,089–73,324,253, 165 basesExon 6: 73,324,955–73,325,195, 241 basesExon 5: 73,325,298–73,325,444, 147 basesExon 4: 73,329,573–73,329,791, 219 basesExon 3: 73,332,131–73,332,292, 162 basesExon 2: 73,343,385–73,343,808, 424 basesExon 1: 73,367,486–73,368,958, 1,473 bases864215′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 6.9 kb of the gene's 49.1 kb; 3,612 of those bases code for the protein.

How a genome test reads HCN4

14

positions in HCN4 where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 49.1 kb of HCN4, introns included, not only the 6.9 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). HCN4 gene: hyperpolarization activated cyclic nucleotide gated potassium channel 4. Retrieved 16 October 2026, from https://dantelabs.com/genes/hcn4

Vancouver

Dante Labs. HCN4 gene: hyperpolarization activated cyclic nucleotide gated potassium channel 4 [Internet]. [cited 16 October 2026]. Available from: https://dantelabs.com/genes/hcn4

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