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Gene

TIAM1

TIAM Rac1 associated GEF 1

Summary

Cytogenetic location
21q22.11
Coordinates
Chromosome 21: 31,118,418–31,344,261 (GRCh38)
Exons
28 exons across 225.8 kb
Protein
1,591 amino acids
MANE Select transcript
ENST00000541036.6NM_001353694.2
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated reports relevant to this gene

No Genome Test report reads TIAM1 yet. The test sequences your whole genome, so your data includes it all the same.

How TIAM1 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 21, with a bracket where TIAM1 sits. TIAM1 and 8 genes near it on chromosome 21, from 30,731,340 to 31,731,339.Chromosome 2121q22.11p13p12p11.2p11.1q11.1q11.2q21.1q21.2q21.3q22.11q22.12q22.13q22.2q22.330.8 Mb31 Mb31.2 Mb31.4 Mb31.6 MbKRTAP21-2: 30,746,794–30,747,259, reverse strandKRTAP21-2KRTAP21-1: 30,755,015–30,755,428, reverse strandKRTAP21-1KRTAP8-1: 30,812,697–30,813,274, reverse strandKRTAP8-1KRTAP7-1: 30,829,039–30,829,759, reverse strandKRTAP7-1KRTAP11-1: 30,880,644–30,881,580, reverse strandKRTAP11-1KRTAP19-8: 31,038,159–31,038,476, reverse strandKRTAP19-8TIAM1: 31,118,418–31,344,261, reverse strandTIAM1SOD1: 31,659,617–31,668,931, forward strandSOD1SCAF4: 31,667,491–31,732,184, reverse strandSCAF4Diagram of TIAM1: 28 exons on the reverse strand of chromosome 21Exon 9: 1 known disease-causing siteExon 4: 1 known disease-causing siteExon 28: 31,118,418–31,120,837, 2,420 basesExon 27: 31,124,522–31,124,694, 173 basesExon 26: 31,127,065–31,127,152, 88 basesExon 25: 31,130,213–31,130,315, 103 basesExon 24: 31,130,890–31,130,948, 59 basesExon 23: 31,135,933–31,136,041, 109 basesExon 22: 31,141,118–31,141,236, 119 basesExon 21: 31,141,325–31,141,504, 180 basesExon 20: 31,146,895–31,147,003, 109 basesExon 19: 31,152,636–31,152,761, 126 basesExon 18: 31,153,066–31,153,134, 69 basesExon 17: 31,154,247–31,154,426, 180 basesExon 16: 31,164,962–31,165,065, 104 basesExon 15: 31,182,421–31,182,645, 225 basesExon 14: 31,187,001–31,187,087, 87 basesExon 13: 31,195,224–31,195,305, 82 basesExon 12: 31,202,908–31,203,012, 105 basesExon 11: 31,210,045–31,210,215, 171 basesExon 10: 31,213,398–31,213,472, 75 basesExon 9: 31,217,553–31,217,699, 147 basesExon 8: 31,223,406–31,223,591, 186 basesExon 7: 31,225,726–31,225,950, 225 basesExon 6: 31,245,488–31,245,660, 173 basesExon 5: 31,251,742–31,252,189, 448 basesExon 4: 31,266,010–31,266,983, 974 basesExon 3: 31,276,732–31,276,908, 177 basesExon 2: 31,339,243–31,339,422, 180 basesExon 1: 31,344,138–31,344,261, 124 bases2825201510515′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 7.2 kb of the gene's 225.8 kb; 4,776 of those bases code for the protein.

How a genome test reads TIAM1

2

positions in TIAM1 where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 225.8 kb of TIAM1, introns included, not only the 7.2 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). TIAM1 gene: TIAM Rac1 associated GEF 1. Retrieved 16 October 2026, from https://dantelabs.com/genes/tiam1

Vancouver

Dante Labs. TIAM1 gene: TIAM Rac1 associated GEF 1 [Internet]. [cited 16 October 2026]. Available from: https://dantelabs.com/genes/tiam1

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