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Gene

COG2

component of oligomeric golgi complex 2

Summary

Cytogenetic location
1q42.2
Coordinates
Chromosome 1: 230,642,481–230,693,982 (GRCh38)
Exons
18 exons across 51.5 kb
Protein
738 amino acids
Previous symbols
LDLC
MANE Select transcript
ENST00000366669.9NM_007357.3
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated report relevant to this gene

    • Congenital Disorders of Glycosylation

      • Congenital Disorders of Glycosylation (CDG)

        One of 98 genes linked to it

        A large group of inherited conditions in which sugar chains (glycans) are not correctly built or attached to proteins and lipids, often affecting the brain, liver, blood clotting, growth and many other body systems. Most are autosomal recessive, but some are X-linked or autosomal dominant.

        • 1 GenCC submitter rates it definitive or strong

    How COG2 is laid out

    • Coding sequence
    • Untranslated region
    • Intron
    • Direction of transcription
    • Known disease-causing sites
    • Stretches short reads find hard
    Chromosome 1, with a bracket where COG2 sits. COG2 and 9 genes near it on chromosome 1, from 230,168,232 to 231,168,231.Chromosome 11q42.2p36.33p36.32p36.31p36.23p36.22p36.21p36.13p36.12p36.11p35.3p35.2p35.1p34.3p34.2p34.1p33p32.3p32.2p32.1p31.3p31.2p31.1p22.3p22.2p22.1p21.3p21.2p21.1p13.3p13.2p13.1p12p11.2p11.1q11q12q21.1q21.2q21.3q22q23.1q23.2q23.3q24.1q24.2q24.3q25.1q25.2q25.3q31.1q31.2q31.3q32.1q32.2q32.3q41q42.11q42.12q42.13q42.2q42.3q43q44230.2 Mb230.4 Mb230.6 Mb230.8 Mb231 MbGALNT2: 230,057,990–230,282,128, forward strandGALNT2PGBD5: 230,314,490–230,426,370, reverse strandPGBD5COG2: 230,642,481–230,693,982, forward strandCOG2AGT: 230,690,776–230,745,576, reverse strandAGTCAPN9: 230,747,266–230,804,397, forward strandCAPN9C1orf198: 230,837,119–230,869,589, reverse strandC1orf198TTC13: 230,902,936–230,978,893, reverse strandTTC13ARV1: 230,978,981–231,000,735, forward strandARV1FAM89A: 230,999,826–231,040,270, reverse strandFAM89ATRIM67: 231,162,058–231,221,565, forward strandTRIM67Diagram of COG2: 18 exons on the forward strand of chromosome 1Exon 3: 1 known disease-causing siteExon 5: 1 known disease-causing siteExon 6: 1 known disease-causing siteExon 13: 1 known disease-causing siteExon 16: 1 known disease-causing siteExon 1: 230,642,481–230,642,678, 198 basesExon 2: 230,659,464–230,659,625, 162 basesExon 3: 230,660,758–230,660,823, 66 basesExon 4: 230,663,141–230,663,221, 81 basesExon 5: 230,664,484–230,664,587, 104 basesExon 6: 230,668,676–230,668,784, 109 basesExon 7: 230,669,356–230,669,535, 180 basesExon 8: 230,671,516–230,671,640, 125 basesExon 9: 230,674,998–230,675,124, 127 basesExon 10: 230,678,913–230,679,052, 140 basesExon 11: 230,683,574–230,683,635, 62 basesExon 12: 230,685,085–230,685,236, 152 basesExon 13: 230,686,935–230,687,132, 198 basesExon 14: 230,688,071–230,688,143, 73 basesExon 15: 230,688,420–230,688,562, 143 basesExon 16: 230,690,014–230,690,153, 140 basesExon 17: 230,691,384–230,691,564, 181 basesExon 18: 230,693,292–230,693,982, 691 bases1246810121416185′3′

    Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

    Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

    Nearby genes from Ensembl release 116, on GRCh38.

    Exons make up 2.9 kb of the gene's 51.5 kb; 2,217 of those bases code for the protein.

    How a genome test reads COG2

    5

    positions in COG2 where ClinVar classes a change as pathogenic or likely pathogenic

    None of them falls in a region short reads find hard.

    A whole genome covers all 51.5 kb of COG2, introns included, not only the 2.9 kb of exons.

    Where this comes from

    • HGNC: the gene's symbol, name, other symbols and location.
    • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
    • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
    • The ACMG secondary findings list, SF v3.2.
    • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
    • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
    • Data release 2026.10.16-c6eea6bf.

    Cite this page

    APA

    Dante Labs. (n.d.). COG2 gene: component of oligomeric golgi complex 2. Retrieved 16 October 2026, from https://dantelabs.com/genes/cog2

    Vancouver

    Dante Labs. COG2 gene: component of oligomeric golgi complex 2 [Internet]. [cited 16 October 2026]. Available from: https://dantelabs.com/genes/cog2

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