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Gene

TKFC

triokinase and FMN cyclase

Summary

Cytogenetic location
11q12.2
Coordinates
Chromosome 11: 61,333,228–61,349,242 (GRCh38)
Exons
18 exons across 16 kb
Protein
575 amino acids
Also known as
DKFZP586B1621, NET45
Previous symbols
DAK
MANE Select transcript
ENST00000394900.8NM_015533.4
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated reports relevant to this gene

No Genome Test report reads TKFC yet. The test sequences your whole genome, so your data includes it all the same.

How TKFC is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 11, with a bracket where TKFC sits. TKFC and 30 genes near it on chromosome 11, from 60,841,235 to 61,841,234.Chromosome 1111q12.2p15.5p15.4p15.3p15.2p15.1p14.3p14.2p14.1p13p12p11.2p11.12p11.11q11q12.1q12.2q12.3q13.1q13.2q13.3q13.4q13.5q14.1q14.2q14.3q21q22.1q22.2q22.3q23.1q23.2q23.3q24.1q24.2q24.3q2561 Mb61.2 Mb61.4 Mb61.6 Mb61.8 MbCCDC86: 60,841,981–60,851,095, forward strandCCDC86PTGDR2: 60,850,933–60,855,987, reverse strandPTGDR2ZP1: 60,867,542–60,875,693, forward strandZP1PRPF19: 60,890,547–60,906,607, reverse strandPRPF19TMEM109: 60,912,521–60,923,443, forward strandTMEM109TMEM132A: 60,924,453–60,937,159, forward strandTMEM132ASLC15A3: 60,937,060–60,952,653, reverse strandSLC15A3CD6: 60,971,651–61,020,377, forward strandCD6CD5: 61,102,466–61,127,952, forward strandCD5VPS37C: 61,111,002–61,167,355, reverse strandVPS37CPGA3: 61,203,307–61,213,098, forward strandPGA3PGA4: 61,222,347–61,231,694, forward strandPGA4PGA5: 61,241,175–61,251,444, forward strandPGA5VWCE: 61,255,672–61,295,553, reverse strandVWCEDDB1: 61,299,447–61,342,596, reverse strandDDB1TKFC: 61,333,228–61,349,242, forward strandTKFCCYB561A3: 61,348,453–61,362,343, reverse strandCYB561A3TMEM138: 61,361,964–61,377,890, forward strandTMEM138TMEM216: 61,392,393–61,400,408, forward strandTMEM216CPSF7: 61,402,641–61,430,105, reverse strandCPSF7: 61,429,220–61,485,822, forward strandSDHAF2: 61,430,032–61,473,614, forward strandSDHAF2SAXO4: 61,481,120–61,490,931, forward strandSAXO4LRRC10B: 61,508,749–61,511,018, forward strandLRRC10BSYT7: 61,513,714–61,581,201, reverse strandSYT7DAGLA: 61,680,151–61,747,003, forward strandDAGLAMYRF: 61,752,593–61,788,518, forward strandMYRFTMEM258: 61,768,455–61,792,802, reverse strandTMEM258FEN1: 61,792,725–61,797,238, forward strandFEN1FADS2: 61,792,980–61,867,354, forward strandFADS1: 61,799,624–61,829,318, reverse strandFADS1Diagram of TKFC: 18 exons on the forward strand of chromosome 11Exon 18: 1 known disease-causing siteExon 1: 61,333,228–61,333,329, 102 basesExon 2: 61,334,620–61,334,731, 112 basesExon 3: 61,337,941–61,338,130, 190 basesExon 4: 61,339,066–61,339,176, 111 basesExon 5: 61,339,254–61,339,435, 182 basesExon 6: 61,341,436–61,341,514, 79 basesExon 7: 61,341,823–61,341,912, 90 basesExon 8: 61,342,461–61,342,495, 35 basesExon 9: 61,342,574–61,342,658, 85 basesExon 10: 61,342,755–61,342,844, 90 basesExon 11: 61,343,342–61,343,458, 117 basesExon 12: 61,343,856–61,343,975, 120 basesExon 13: 61,344,136–61,344,273, 138 basesExon 14: 61,345,260–61,345,366, 107 basesExon 15: 61,345,462–61,345,565, 104 basesExon 16: 61,345,712–61,345,745, 34 basesExon 17: 61,345,857–61,345,946, 90 basesExon 18: 61,346,351–61,349,242, 2,892 bases1246810121416185′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 4.7 kb of the gene's 16 kb; 1,728 of those bases code for the protein.

How a genome test reads TKFC

1

position in TKFC where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 16 kb of TKFC, introns included, not only the 4.7 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). TKFC gene: triokinase and FMN cyclase. Retrieved 16 October 2026, from https://dantelabs.com/genes/tkfc

Vancouver

Dante Labs. TKFC gene: triokinase and FMN cyclase [Internet]. [cited 16 October 2026]. Available from: https://dantelabs.com/genes/tkfc

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