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Gene

GP6

glycoprotein VI platelet

Summary

Cytogenetic location
19q13.42
Coordinates
Chromosome 19: 55,013,705–55,038,264 (GRCh38)
Exons
8 exons across 24.6 kb
Protein
339 amino acids
Inheritance
Autosomal recessive
Also known as
GPVI
MANE Select transcript
ENST00000417454.5NM_016363.5
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated report relevant to this gene

  • Inherited Platelet Function Disorders

    • GP6-Related Platelet Disorder (Platelet-Type Bleeding Disorder 11)Autosomal recessive

      A recessive disorder of the platelet collagen receptor glycoprotein VI, encoded by GP6, usually causing mild bleeding.

      • ClinGen rates the link definitive
      • 3 GenCC submitters rate it definitive or strong
      What knowing changes

      Knowing about it helps plan bleeding prevention around surgery, dental work and childbirth, and avoid medicines that affect platelet function.

Inheritance

Autosomal recessive
It takes a changed copy from each parent. With one, you are a carrier and usually unaffected; when both parents are carriers, each child has a one-in-four chance of inheriting two.

How GP6 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 19, with a bracket where GP6 sits. GP6 and 44 genes near it on chromosome 19, from 54,525,985 to 55,525,984.Chromosome 1919q13.42p13.3p13.2p13.13p13.12p13.11p12p11q11q12q13.11q13.12q13.13q13.2q13.31q13.32q13.33q13.41q13.42q13.4354.6 Mb54.8 Mb55 Mb55.2 Mb55.4 MbLILRA2: 54,572,920–54,590,287, forward strandLILRA2LILRA1: 54,593,582–54,603,259, forward strandLILRA1LILRB1: 54,616,309–54,638,022, forward strandLILRB1LILRB4: 54,643,889–54,670,531, forward strandLILRB4KIR3DL3: 54,724,442–54,736,632, forward strandKIR3DL3KIR2DL3: 54,738,505–54,753,061, forward strandKIR2DL3KIR2DL1: 54,769,793–54,784,332, forward strandKIR2DL1KIR2DL4: 54,803,610–54,814,517, forward strandKIR2DL4KIR3DL1: 54,816,440–54,830,778, forward strandKIR3DL1KIR2DS4: 54,832,676–54,848,569, forward strandKIR2DS4KIR3DL2: 54,850,433–54,867,209, forward strandKIR3DL2FCAR: 54,874,227–54,891,420, forward strandFCARNCR1: 54,906,112–54,941,199, forward strandNCR1NLRP7: 54,923,454–54,966,312, reverse strandNLRP7NLRP2: 54,953,130–55,001,142, forward strandNLRP2GP6: 55,013,705–55,038,264, reverse strandGP6RDH13: 55,039,108–55,071,291, reverse strandRDH13EPS8L1: 55,072,020–55,090,124, forward strandEPS8L1PPP1R12C: 55,090,913–55,117,679, reverse strandPPP1R12CTNNT1: 55,131,662–55,149,351, reverse strandTNNT1TNNI3: 55,151,763–55,157,774, reverse strandTNNI3: 55,154,757–55,160,671, reverse strandDNAAF3: 55,158,661–55,166,722, reverse strandDNAAF3SYT5: 55,171,196–55,180,328, reverse strandPTPRH: 55,181,230–55,209,512, reverse strandPTPRHTMEM86B: 55,226,524–55,228,784, reverse strandTMEM86BPPP6R1: 55,229,776–55,259,070, reverse strandPPP6R1HSPBP1: 55,262,219–55,280,930, reverse strandHSPBP1BRSK1: 55,282,072–55,312,592, forward strandBRSK1TMEM150B: 55,309,440–55,334,048, reverse strandTMEM150BKMT5C: 55,339,367–55,348,122, forward strandKMT5CCOX6B2: 55,349,306–55,354,754, reverse strandCOX6B2: 55,352,301–55,359,516, reverse strandGARIN5B: 55,354,908–55,363,260, reverse strandIL11: 55,364,382–55,370,463, reverse strandTMEM190: 55,376,816–55,378,246, forward strandTMEM238: 55,379,244–55,384,305, reverse strandRPL28: 55,383,856–55,403,342, forward strandUBE2S: 55,385,311–55,408,164, reverse strandUBE2SSHISA7: 55,428,740–55,452,900, reverse strandSHISA7ISOC2: 55,452,975–55,462,343, reverse strandISOC2C19orf85: 55,463,001–55,464,752, reverse strandC19orf85ZNF628: 55,476,597–55,484,487, forward strandZNF628NAT14: 55,484,949–55,487,578, forward strandSSC5D: 55,488,404–55,519,099, forward strandDiagram of GP6: 8 exons on the reverse strand of chromosome 19Exon 6: 1 known disease-causing siteExon 4: 1 known disease-causing siteExon 8: 55,013,705–55,015,165, 1,461 basesExon 7: 55,015,683–55,015,733, 51 basesExon 6: 55,018,652–55,018,711, 60 basesExon 5: 55,025,218–55,025,271, 54 basesExon 4: 55,027,578–55,027,862, 285 basesExon 3: 55,032,139–55,032,396, 258 basesExon 2: 55,032,506–55,032,538, 33 basesExon 1: 55,038,203–55,038,264, 62 bases864215′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 2.3 kb of the gene's 24.6 kb; 1,020 of those bases code for the protein.

How a genome test reads GP6

2

positions in GP6 where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 24.6 kb of GP6, introns included, not only the 2.3 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). GP6 gene: glycoprotein VI platelet. Retrieved 16 October 2026, from https://dantelabs.com/genes/gp6

Vancouver

Dante Labs. GP6 gene: glycoprotein VI platelet [Internet]. [cited 16 October 2026]. Available from: https://dantelabs.com/genes/gp6

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