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Gene

NLRP7

NLR family pyrin domain containing 7

Summary

Cytogenetic location
19q13.42
Coordinates
Chromosome 19: 54,923,515–54,947,530 (GRCh38)
Exons
11 exons across 24 kb
Protein
1,037 amino acids
Also known as
PYPAF3, NOD12, PAN7, CLR19.4
Previous symbols
NALP7
MANE Select transcript
ENST00000592784.6NM_001127255.2
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated reports relevant to this gene

No Genome Test report reads NLRP7 yet. The test sequences your whole genome, so your data includes it all the same.

How NLRP7 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 19, with a bracket where NLRP7 sits. NLRP7 and 44 genes near it on chromosome 19, from 54,435,523 to 55,435,522.Chromosome 1919q13.42p13.3p13.2p13.13p13.12p13.11p12p11q11q12q13.11q13.12q13.13q13.2q13.31q13.32q13.33q13.41q13.42q13.4354.6 Mb54.8 Mb55 Mb55.2 Mb55.4 MbTTYH1: 54,415,219–54,436,904, forward strandTTYH1LENG8: 54,449,157–54,462,022, forward strandLENG8LENG9: 54,461,732–54,463,778, reverse strandLENG9CDC42EP5: 54,465,026–54,473,316, reverse strandCDC42EP5LAIR2: 54,497,879–54,510,694, forward strandLAIR2LILRA2: 54,572,920–54,590,287, forward strandLILRA2LILRA1: 54,593,582–54,603,259, forward strandLILRA1LILRB1: 54,616,309–54,638,022, forward strandLILRB1LILRB4: 54,643,889–54,670,531, forward strandLILRB4KIR3DL3: 54,724,442–54,736,632, forward strandKIR3DL3KIR2DL3: 54,738,505–54,753,061, forward strandKIR2DL3KIR2DL1: 54,769,793–54,784,332, forward strandKIR2DL1KIR2DL4: 54,803,610–54,814,517, forward strandKIR2DL4KIR3DL1: 54,816,440–54,830,778, forward strandKIR3DL1KIR2DS4: 54,832,676–54,848,569, forward strandKIR2DS4KIR3DL2: 54,850,433–54,867,209, forward strandKIR3DL2FCAR: 54,874,227–54,891,420, forward strandFCARNCR1: 54,906,112–54,941,199, forward strandNCR1NLRP7: 54,923,515–54,947,530, reverse strandNLRP7NLRP2: 54,953,130–55,001,142, forward strandNLRP2GP6: 55,012,055–55,038,264, reverse strandGP6RDH13: 55,039,108–55,071,291, reverse strandRDH13EPS8L1: 55,072,020–55,090,124, forward strandEPS8L1PPP1R12C: 55,090,913–55,117,679, reverse strandPPP1R12CTNNT1: 55,131,662–55,149,351, reverse strandTNNT1TNNI3: 55,151,763–55,157,774, reverse strandTNNI3: 55,154,757–55,160,671, reverse strandDNAAF3: 55,158,661–55,166,722, reverse strandDNAAF3SYT5: 55,171,196–55,180,328, reverse strandPTPRH: 55,181,230–55,209,512, reverse strandPTPRHTMEM86B: 55,226,524–55,228,784, reverse strandTMEM86BPPP6R1: 55,229,776–55,259,070, reverse strandPPP6R1HSPBP1: 55,262,219–55,280,930, reverse strandHSPBP1BRSK1: 55,282,072–55,312,592, forward strandBRSK1TMEM150B: 55,309,440–55,334,048, reverse strandTMEM150BKMT5C: 55,339,367–55,348,122, forward strandKMT5CCOX6B2: 55,349,306–55,354,754, reverse strandCOX6B2: 55,352,301–55,359,516, reverse strandGARIN5B: 55,354,908–55,363,260, reverse strandIL11: 55,364,382–55,370,463, reverse strandTMEM190: 55,376,816–55,378,246, forward strandTMEM238: 55,379,244–55,384,305, reverse strandRPL28: 55,383,856–55,403,342, forward strandUBE2S: 55,385,311–55,408,164, reverse strandUBE2SSHISA7: 55,428,740–55,452,900, reverse strandSHISA7Diagram of NLRP7: 11 exons on the reverse strand of chromosome 19Exon 9: 1 known disease-causing siteExon 7: 1 known disease-causing siteExon 6: 4 known disease-causing sitesExon 5: 2 known disease-causing sitesExon 4: 2 known disease-causing sitesExon 3: 1 known disease-causing siteExon 11: 54,923,515–54,923,872, 358 basesExon 10: 54,927,605–54,927,775, 171 basesExon 9: 54,930,499–54,930,666, 168 basesExon 8: 54,933,569–54,933,739, 171 basesExon 7: 54,934,489–54,934,659, 171 basesExon 6: 54,936,261–54,936,431, 171 basesExon 5: 54,938,044–54,938,241, 198 basesExon 4: 54,938,888–54,940,466, 1,579 basesExon 3: 54,940,931–54,941,005, 75 basesExon 2: 54,941,435–54,941,750, 316 basesExon 1: 54,947,469–54,947,530, 62 bases11109876543215′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 3.4 kb of the gene's 24 kb; 3,114 of those bases code for the protein.

How a genome test reads NLRP7

13

positions in NLRP7 where ClinVar classes a change as pathogenic or likely pathogenic

2 of them (15%) fall in regions short reads find hard.

  • Low mappability (1 site)Regions where 100 bp or 250 bp reads cannot be placed uniquely.
  • Segmental duplications (2 sites)Copies of at least 1 kb sharing at least 90% identity with another part of the genome (paralogues, pseudogenes); reads may align to the wrong copy.

A whole genome covers all 24 kb of NLRP7, introns included, not only the 3.4 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). NLRP7 gene: NLR family pyrin domain containing 7. Retrieved 17 October 2026, from https://dantelabs.com/genes/nlrp7

Vancouver

Dante Labs. NLRP7 gene: NLR family pyrin domain containing 7 [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/nlrp7

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