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Trait

Pulmonary hemorrhage

Pulmonary hemorrhage is a bleeding within the lungs. Older children and adults may spit blood or bloody sputum. Neonates, infants and young children usually do not spit up blood. Anemia, pulmonary infiltrates, increasingling bloody return on BAL and the presence of hemosiderin-laden macrophages in broncho-alveolar lavage (BAL) fluid or lung biopsy can diagnose lung bleeding. Alveolar macrophages contain phagocytosed red blood cells and stain positive for hemosiderin, a product of hemoglobin degradation, after about 48-72 hours following pulmonary hemorraghe. Previous or recurrent bleeding can thus be distinguished from fresh events. A differentiation into local or diffuse is of importance. Also differentiate if pulmonary hemorrhage is due to a primary lung disorder or a manifestation of a systemic disease.

HPO HP:0040223

Summary

Also called
Intrapulmonary haemorrhage, Intrapulmonary hemorrhage, Pulmonary haemorrhage
Body system
Abnormality of blood and blood-forming tissuesAbnormality of the cardiovascular systemAbnormality of the respiratory system

8 genes linked to Pulmonary hemorrhage

Changes in these genes cause rare conditions in which Pulmonary hemorrhage is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.

GeneHow often it is seenConditions
AMOTL1angiomotin like 1AlwaysIn 1 condition
SLC35A1solute carrier family 35 member A1Very often (80–99%)In 2 conditions
COPAcoat protein complex I subunit alphaOften (30–79%)In 1 condition
ZNFX1zinc finger NFX1-type containing 1Often (30–79%)In 1 condition
CTCFCCCTC-binding factorSometimes (5–29%)In 1 condition
SP110SP110 nuclear body proteinSometimes (5–29%)In 1 condition
ENGendoglinNot recordedIn 1 condition
SLC7A7solute carrier family 7 member 7Not recordedIn 1 condition

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Narrower traits

Broader traits

Abnormality of lung structureInternal bleeding

Where this comes from

  • The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

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