Trait

Abnormal circulating immunoglobulin concentration

An abnormal deviation from normal levels of immunoglobulins in blood.

Also called: Abnormal immunoglobulin concentration, Abnormal immunoglobulin level, Abnormal serum immunoglobulin concentration, Abnormal serum immunoglobulin levels, Abnormal serum level of immunoglobulin, Immunoglobulin abnormality
Body system: Abnormal cellular phenotype Abnormality of blood and blood-forming tissues Laboratory abnormality Abnormality of the immune system

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8 genes linked to Abnormal circulating immunoglobulin concentration

Changes in these genes cause rare conditions in which Abnormal circulating immunoglobulin concentration is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.

Gene	How often it is seen	Conditions
IKBKGinhibitor of nuclear factor kappa B kinase regulatory subunit gamma	Very often (80–99%)	In 1 condition
IL2RGinterleukin 2 receptor subunit gamma	Very often (80–99%)	In 1 condition
NFKBIANFKB inhibitor alpha	Very often (80–99%)	In 1 condition
CD28CD28 molecule	Sometimes (5–29%)	In 1 condition
CTLA4cytotoxic T-lymphocyte associated protein 4	Sometimes (5–29%)	In 1 condition
SLC7A7solute carrier family 7 member 7	Sometimes (5–29%)	In 1 condition
TNFRSF1BTNF receptor superfamily member 1B	Sometimes (5–29%)	In 1 condition
SMARCAL1SNF2 related chromatin remodeling annealing helicase 1	Not recorded	In 1 condition

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Narrower traits

Broader traits

Abnormality of B cell physiology Abnormality of humoral immunity

Where this comes from

The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
Data release 2026.10.16-c6eea6bf.

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