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Trait
Generalized dystonia
A type of dystonia that affects all or most of the body.
Summary
- Also called
- Generalised dystonia
- Body system
- Abnormality of the nervous system
Generalized dystoniaHP:0007325
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Read the genes linked to Generalized dystonia, and the rest of your genome, with one test.
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Get my Genome Test38 genes linked to Generalized dystonia
Changes in these genes cause rare conditions in which Generalized dystonia is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.
| Gene | How often it is seen | Conditions |
|---|---|---|
| ACTBactin beta | Always | In 2 conditions |
| ATP5F1BATP synthase F1 subunit beta | Always | In 1 condition |
| MCCC1methylcrotonyl-CoA carboxylase subunit 1 | Always | In 1 condition |
| MRPS25mitochondrial ribosomal protein S25 | Always | In 1 condition |
| NAV3neuron navigator 3 | Always | In 1 condition |
| NDUFAF6NADH:ubiquinone oxidoreductase complex assembly factor 6 | Always | In 1 condition |
| PLP1proteolipid protein 1 | Always | In 1 condition |
| PRKRAprotein activator of interferon induced protein kinase EIF2AK2 | Always | In 1 condition |
| TNRtenascin R | Always | In 1 condition |
| TOR1Atorsin family 1 member A | Always | In 1 condition |
| TSPOAP1TSPO associated protein 1 | Always | In 2 conditions |
| VPS41VPS41 subunit of HOPS complex | Always | In 1 condition |
| KMT2Blysine methyltransferase 2B | Very often (80–99%) | In 1 condition |
| THAP1THAP domain containing 1 | Very often (80–99%) | In 1 condition |
| TUBB4Atubulin beta 4A class IVa | Very often (80–99%) | In 2 conditions |
| ALS2alsin Rho guanine nucleotide exchange factor ALS2 | Often (30–79%) | In 1 condition |
| AOPEPaminopeptidase O (putative) | Often (30–79%) | In 1 condition |
| ATP5F1AATP synthase F1 subunit alpha | Often (30–79%) | In 1 condition |
| C19orf12chromosome 19 open reading frame 12 | Often (30–79%) | In 1 condition |
| CHD8chromodomain helicase DNA binding protein 8 | Often (30–79%) | In 1 condition |
| COQ4coenzyme Q4 | Often (30–79%) | In 1 condition |
| DLATdihydrolipoamide S-acetyltransferase | Often (30–79%) | In 1 condition |
| FA2Hfatty acid 2-hydroxylase | Often (30–79%) | In 2 conditions |
| NDUFA2NADH:ubiquinone oxidoreductase subunit A2 | Often (30–79%) | In 1 condition |
| NUP54nucleoporin 54 | Often (30–79%) | In 1 condition |
| PANK2pantothenate kinase 2 | Often (30–79%) | In 1 condition |
| SLC39A14solute carrier family 39 member 14 | Often (30–79%) | In 1 condition |
| TIMM8Atranslocase of inner mitochondrial membrane 8A | Often (30–79%) | In 1 condition |
| GCH1GTP cyclohydrolase 1 | Sometimes (5–29%) | In 1 condition |
| HPCAhippocalcin | Sometimes (5–29%) | In 1 condition |
| IMPDH2inosine monophosphate dehydrogenase 2 | Sometimes (5–29%) | In 1 condition |
| JAM2junctional adhesion molecule 2 | Sometimes (5–29%) | In 1 condition |
| LRPPRCleucine rich pentatricopeptide repeat containing | Sometimes (5–29%) | In 1 condition |
| NAXDNAD(P)HX dehydratase | Sometimes (5–29%) | In 1 condition |
| NR4A2nuclear receptor subfamily 4 group A member 2 | Sometimes (5–29%) | In 1 condition |
| THtyrosine hydroxylase | Sometimes (5–29%) | In 1 condition |
| UFC1ubiquitin-fold modifier conjugating enzyme 1 | Sometimes (5–29%) | In 1 condition |
| SUOXsulfite oxidase | Not recorded | In 1 condition |
How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.
Broader traits
Where this comes from
- The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
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