Trait
Severe gum disease
Clinical name: Severe periodontitis
Increased susceptibility to periodontitis, as manifested by severe periodontal infection with rapid alveolar bone loss, tooth mobility, and premature tooth exfoliation.
Summary
- Also called
- Early-onset aggressive periodontitis, Prepubertal periodontitis, Severe aggressive periodontitis, Severe periodontal disease, Severe pyorrhea
Reference genomeGRCh38hg38
Positions on gene and variant pages follow this choice, in this browser.
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Get my Genome Test7 genes linked to Severe gum disease
Changes in these genes cause rare conditions in which Severe gum disease is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.
| Gene | How often it is seen | Conditions |
|---|---|---|
| CTSCcathepsin C | Always | In 4 conditions |
| SKOR2SKI family transcriptional corepressor 2 | Always | In 1 condition |
| C1Rcomplement C1r | Very often (80–99%) | In 1 condition |
| C1Scomplement C1s | Very often (80–99%) | In 1 condition |
| CATcatalase | Sometimes (5–29%) | In 1 condition |
| SLC35C1solute carrier family 35 member C1 | Sometimes (5–29%) | In 1 condition |
| CXCR4C-X-C motif chemokine receptor 4 | Rarely (1–4%) | In 1 condition |
How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.
Broader traits
Where this comes from
- The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
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