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Gene

LARGE2

LARGE xylosyl- and glucuronyltransferase 2

Summary

Cytogenetic location
11p11.2
Coordinates
Chromosome 11: 45,922,656–45,929,096 (GRCh38)
Exons
14 exons across 6.4 kb
Protein
721 amino acids
Also known as
PP5656, FLJ35207
Previous symbols
GYLTL1B
MANE Select transcript
ENST00000401752.6NM_001300721.2
Locus type
gene with protein product

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated reports relevant to this gene

No Genome Test report reads LARGE2 yet. The test sequences your whole genome, so your data includes it all the same.

How LARGE2 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Stretches short reads find hard
Chromosome 11, with a bracket where LARGE2 sits. LARGE2 and 12 genes near it on chromosome 11, from 45,425,876 to 46,425,875.Chromosome 1111p11.2p15.5p15.4p15.3p15.2p15.1p14.3p14.2p14.1p13p12p11.2p11.12p11.11q11q12.1q12.2q12.3q13.1q13.2q13.3q13.4q13.5q14.1q14.2q14.3q21q22.1q22.2q22.3q23.1q23.2q23.3q24.1q24.2q24.3q2545.6 Mb45.8 Mb46 Mb46.2 Mb46.4 MbCHST1: 45,647,689–45,666,096, reverse strandCHST1SLC35C1: 45,804,071–45,813,016, forward strandSLC35C1CRY2: 45,847,118–45,883,248, forward strandCRY2MAPK8IP1: 45,885,593–45,906,470, forward strandMAPK8IP1FREY1: 45,906,513–45,907,272, reverse strandFREY1PEX16: 45,909,663–45,918,854, reverse strandPEX16LARGE2: 45,922,656–45,929,096, forward strandLARGE2PHF21A: 45,929,319–46,121,473, reverse strandCREB3L1: 46,277,636–46,321,422, forward strandCREB3L1DGKZ: 46,332,665–46,380,555, forward strandDGKZMDK: 46,380,748–46,383,837, forward strandMDKCHRM4: 46,383,589–46,391,990, reverse strandCHRM4AMBRA1: 46,396,414–46,594,242, reverse strandAMBRA1Diagram of LARGE2: 14 exons on the forward strand of chromosome 11Exon 1: 45,922,656–45,922,728, 73 basesExon 2: 45,922,821–45,923,167, 347 basesExon 3: 45,923,473–45,923,555, 83 basesExon 4: 45,924,154–45,924,277, 124 basesExon 5: 45,924,506–45,924,677, 172 basesExon 6: 45,924,785–45,924,889, 105 basesExon 7: 45,926,039–45,926,151, 113 basesExon 8: 45,926,222–45,926,347, 126 basesExon 9: 45,926,442–45,926,597, 156 basesExon 10: 45,926,711–45,926,871, 161 basesExon 11: 45,927,315–45,927,593, 279 basesExon 12: 45,927,920–45,928,069, 150 basesExon 13: 45,928,177–45,928,372, 196 basesExon 14: 45,928,630–45,929,096, 467 bases12345678910111213145′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 2.6 kb of the gene's 6.4 kb; 2,166 of those bases code for the protein.

How a genome test reads LARGE2

1

position in LARGE2 where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 6.4 kb of LARGE2, introns included, not only the 2.6 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). LARGE2 gene: LARGE xylosyl- and glucuronyltransferase 2. Retrieved 17 October 2026, from https://dantelabs.com/genes/large2

Vancouver

Dante Labs. LARGE2 gene: LARGE xylosyl- and glucuronyltransferase 2 [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/large2

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