Trait
Multiple small spleens
Clinical name: Polysplenia
Polysplenia is a congenital disease manifested by multiple small accessory spleens.
Summary
- Also called
- Accessory spleens, Multiple accessory spleens
Reference genomeGRCh38hg38
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Read the genes linked to Multiple small spleens, and the rest of your genome, with one test.
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Get my Genome Test72 genes linked to Multiple small spleens
Changes in these genes cause rare conditions in which Multiple small spleens is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.
| Gene | How often it is seen | Conditions |
|---|---|---|
| DAND5DAN domain BMP antagonist family member 5 | Always | In 1 condition |
| FRYLFRY like transcription coactivator | Always | In 1 condition |
| RFWD3ring finger and WD repeat domain 3 | Always | In 1 condition |
| ACVR2Bactivin A receptor type 2B | Often (30–79%) | In 1 condition |
| CFAP45cilia and flagella associated protein 45 | Often (30–79%) | In 1 condition |
| CFC1cryptic, EGF-CFC family member 1 | Often (30–79%) | In 1 condition |
| CLXNcalaxin | Often (30–79%) | In 2 conditions |
| YARS1tyrosyl-tRNA synthetase 1 | Often (30–79%) | In 1 condition |
| ZIC3Zic family zinc finger 3 | Often (30–79%) | In 1 condition |
| CCDC39coiled-coil domain 39 molecular ruler complex subunit | Sometimes (5–29%) | In 2 conditions |
| CIROZciliated left-right organizer protein containing ZP-N domains | Sometimes (5–29%) | In 1 condition |
| DNAAF4dynein axonemal assembly factor 4 | Sometimes (5–29%) | In 2 conditions |
| GPC3glypican 3 | Sometimes (5–29%) | In 2 conditions |
| GPC4glypican 4 | Sometimes (5–29%) | In 1 condition |
| MEGF8multiple EGF like domains 8 | Sometimes (5–29%) | In 1 condition |
| RAB23RAB23, member RAS oncogene family | Sometimes (5–29%) | In 2 conditions |
| BRWD1bromodomain and WD repeat domain containing 1 | Rarely (1–4%) | In 1 condition |
| CCDC40coiled-coil domain 40 molecular ruler complex subunit | Rarely (1–4%) | In 1 condition |
| CCNOcyclin O | Rarely (1–4%) | In 1 condition |
| CFAP221cilia and flagella associated protein 221 | Rarely (1–4%) | In 1 condition |
| CFAP298cilia and flagella associated protein 298 | Rarely (1–4%) | In 1 condition |
| CFAP300cilia and flagella associated protein 300 | Rarely (1–4%) | In 1 condition |
| CFAP74cilia and flagella associated protein 74 | Rarely (1–4%) | In 1 condition |
| DAW1dynein assembly factor with WD repeats 1 | Rarely (1–4%) | In 1 condition |
| DNAAF1dynein axonemal assembly factor 1 | Rarely (1–4%) | In 1 condition |
| DNAAF11dynein axonemal assembly factor 11 | Rarely (1–4%) | In 1 condition |
| DNAAF19dynein axonemal assembly factor 19 | Rarely (1–4%) | In 1 condition |
| DNAAF2dynein axonemal assembly factor 2 | Rarely (1–4%) | In 1 condition |
| DNAAF3dynein axonemal assembly factor 3 | Rarely (1–4%) | In 1 condition |
| DNAAF5dynein axonemal assembly factor 5 | Rarely (1–4%) | In 1 condition |
| DNAAF6dynein axonemal assembly factor 6 | Rarely (1–4%) | In 1 condition |
| DNAH1dynein axonemal heavy chain 1 | Rarely (1–4%) | In 1 condition |
| DNAH11dynein axonemal heavy chain 11 | Rarely (1–4%) | In 1 condition |
| DNAH5dynein axonemal heavy chain 5 | Rarely (1–4%) | In 1 condition |
| DNAH7dynein axonemal heavy chain 7 | Rarely (1–4%) | In 1 condition |
| DNAH9dynein axonemal heavy chain 9 | Rarely (1–4%) | In 1 condition |
| DNAI1dynein axonemal intermediate chain 1 | Rarely (1–4%) | In 1 condition |
| DNAI2dynein axonemal intermediate chain 2 | Rarely (1–4%) | In 1 condition |
| DNAJB13DnaJ heat shock protein family (Hsp40) member B13 | Rarely (1–4%) | In 1 condition |
| DNAL1dynein axonemal light chain 1 | Rarely (1–4%) | In 1 condition |
Show 32 more genes
| Gene | How often it is seen | Conditions |
|---|---|---|
| DRC1dynein regulatory complex subunit 1 | Rarely (1–4%) | In 1 condition |
| DRC2dynein regulatory complex subunit 2 | Rarely (1–4%) | In 1 condition |
| DRC4dynein regulatory complex subunit 4 | Rarely (1–4%) | In 1 condition |
| FOXJ1forkhead box J1 | Rarely (1–4%) | In 1 condition |
| GAS2L2growth arrest specific 2 like 2 | Rarely (1–4%) | In 1 condition |
| HYDINHYDIN axonemal central pair apparatus protein | Rarely (1–4%) | In 1 condition |
| LRRC56leucine rich repeat containing 56 | Rarely (1–4%) | In 1 condition |
| MCIDASmulticiliate differentiation and DNA synthesis associated cell cycle protein | Rarely (1–4%) | In 1 condition |
| NEK10NIMA related kinase 10 | Rarely (1–4%) | In 1 condition |
| NME5NME/NM23 family member 5 | Rarely (1–4%) | In 1 condition |
| NME8NME/NM23 family member 8 | Rarely (1–4%) | In 1 condition |
| ODAD1outer dynein arm docking complex subunit 1 | Rarely (1–4%) | In 1 condition |
| ODAD2outer dynein arm docking complex subunit 2 | Rarely (1–4%) | In 1 condition |
| ODAD3outer dynein arm docking complex subunit 3 | Rarely (1–4%) | In 1 condition |
| ODAD4outer dynein arm docking complex subunit 4 | Rarely (1–4%) | In 1 condition |
| OFD1OFD1 centriole and centriolar satellite protein | Rarely (1–4%) | In 1 condition |
| RPGRretinitis pigmentosa GTPase regulator | Rarely (1–4%) | In 1 condition |
| RSPH1radial spoke head component 1 | Rarely (1–4%) | In 1 condition |
| RSPH3radial spoke head 3 | Rarely (1–4%) | In 1 condition |
| RSPH4Aradial spoke head component 4A | Rarely (1–4%) | In 1 condition |
| RSPH9radial spoke head component 9 | Rarely (1–4%) | In 1 condition |
| SPAG1sperm associated antigen 1 | Rarely (1–4%) | In 1 condition |
| SPEF2sperm flagellar and cilia associated 2 | Rarely (1–4%) | In 1 condition |
| STK36serine/threonine kinase 36 | Rarely (1–4%) | In 1 condition |
| TTC12tetratricopeptide repeat domain 12 | Rarely (1–4%) | In 1 condition |
| ZMYND10zinc finger MYND-type containing 10 | Rarely (1–4%) | In 1 condition |
| CDONcell adhesion associated, oncogene regulated | Not recorded | In 1 condition |
| GDF1growth differentiation factor 1 | Not recorded | In 1 condition |
| MMP21matrix metallopeptidase 21 | Not recorded | In 1 condition |
| MYCNMYCN proto-oncogene, bHLH transcription factor | Not recorded | In 1 condition |
| NPHP3nephrocystin 3 | Not recorded | In 1 condition |
| WDR35WD repeat domain 35 | Not recorded | In 1 condition |
How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.
Broader traits
Where this comes from
- The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
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